Higher risk of carotid plaque among lean individuals with non-alcoholic fatty liver disease: A retrospective study.
<h4>Background</h4>Lean individual with non-alcoholic fatty liver disease (L-NAFLD) is a prominent area of research, yet its pathogenesis and association with other diseases such as atherosclerotic cardiovascular disease remain uncertain.<h4>Object</h4>A retrospective study,...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0316997 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206788069261312 |
|---|---|
| author | Jiangfeng Xue Lun Zhao Liang Shao Huiwang Zhang Yewei Feng Ping Shuai |
| author_facet | Jiangfeng Xue Lun Zhao Liang Shao Huiwang Zhang Yewei Feng Ping Shuai |
| author_sort | Jiangfeng Xue |
| collection | DOAJ |
| description | <h4>Background</h4>Lean individual with non-alcoholic fatty liver disease (L-NAFLD) is a prominent area of research, yet its pathogenesis and association with other diseases such as atherosclerotic cardiovascular disease remain uncertain.<h4>Object</h4>A retrospective study, investigate the association between non-alcoholic fatty liver disease (NAFLD) and carotid plaque (CP) in lean [body mass index (BMI) <24Kg/m2] and non-lean (BMI≥24Kg/m2) populations, as well as identify the related influence factors.<h4>Method</h4>3,587 participants were eligible and categorized into 4 groups based on the presence with CP and BMI, binary logistic regression analysis was utilized alongside other statistical methods.<h4>Results</h4>L-NAFLD participants had a 1.395-fold higher risk of CP compared to lean individuals without NAFLD. Age, gender, systolic blood pressure, low-density lipoprotein cholesterol, fasting blood glucose, and Fibrosis-4 index (FIB-4) were identified as independent risk factors with cutoff values lower than the normal upper limits. However, this association was not observed among non-lean participants, regardless of confounding factors adjustment. Moreover, the impact of FIB-4 on the association of NAFLD and CP was more significant in lean CP participants (OR = 1.360 for 1.30 ~ 2.67, and OR = 2.002 for >2.67~<3.48) than in non-lean CP ones.<h4>Conclusion</h4>The L-NAFLD population had a higher risk of CP, while lean CP individuals experienced more severe liver fibrosis. Implementing stricter management of risk factors may improve the health status of high-risk populations. |
| format | Article |
| id | doaj-art-5bafcb70c96048cf8d68a6cc6cf350fb |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-5bafcb70c96048cf8d68a6cc6cf350fb2025-02-07T05:30:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01202e031699710.1371/journal.pone.0316997Higher risk of carotid plaque among lean individuals with non-alcoholic fatty liver disease: A retrospective study.Jiangfeng XueLun ZhaoLiang ShaoHuiwang ZhangYewei FengPing Shuai<h4>Background</h4>Lean individual with non-alcoholic fatty liver disease (L-NAFLD) is a prominent area of research, yet its pathogenesis and association with other diseases such as atherosclerotic cardiovascular disease remain uncertain.<h4>Object</h4>A retrospective study, investigate the association between non-alcoholic fatty liver disease (NAFLD) and carotid plaque (CP) in lean [body mass index (BMI) <24Kg/m2] and non-lean (BMI≥24Kg/m2) populations, as well as identify the related influence factors.<h4>Method</h4>3,587 participants were eligible and categorized into 4 groups based on the presence with CP and BMI, binary logistic regression analysis was utilized alongside other statistical methods.<h4>Results</h4>L-NAFLD participants had a 1.395-fold higher risk of CP compared to lean individuals without NAFLD. Age, gender, systolic blood pressure, low-density lipoprotein cholesterol, fasting blood glucose, and Fibrosis-4 index (FIB-4) were identified as independent risk factors with cutoff values lower than the normal upper limits. However, this association was not observed among non-lean participants, regardless of confounding factors adjustment. Moreover, the impact of FIB-4 on the association of NAFLD and CP was more significant in lean CP participants (OR = 1.360 for 1.30 ~ 2.67, and OR = 2.002 for >2.67~<3.48) than in non-lean CP ones.<h4>Conclusion</h4>The L-NAFLD population had a higher risk of CP, while lean CP individuals experienced more severe liver fibrosis. Implementing stricter management of risk factors may improve the health status of high-risk populations.https://doi.org/10.1371/journal.pone.0316997 |
| spellingShingle | Jiangfeng Xue Lun Zhao Liang Shao Huiwang Zhang Yewei Feng Ping Shuai Higher risk of carotid plaque among lean individuals with non-alcoholic fatty liver disease: A retrospective study. PLoS ONE |
| title | Higher risk of carotid plaque among lean individuals with non-alcoholic fatty liver disease: A retrospective study. |
| title_full | Higher risk of carotid plaque among lean individuals with non-alcoholic fatty liver disease: A retrospective study. |
| title_fullStr | Higher risk of carotid plaque among lean individuals with non-alcoholic fatty liver disease: A retrospective study. |
| title_full_unstemmed | Higher risk of carotid plaque among lean individuals with non-alcoholic fatty liver disease: A retrospective study. |
| title_short | Higher risk of carotid plaque among lean individuals with non-alcoholic fatty liver disease: A retrospective study. |
| title_sort | higher risk of carotid plaque among lean individuals with non alcoholic fatty liver disease a retrospective study |
| url | https://doi.org/10.1371/journal.pone.0316997 |
| work_keys_str_mv | AT jiangfengxue higherriskofcarotidplaqueamongleanindividualswithnonalcoholicfattyliverdiseasearetrospectivestudy AT lunzhao higherriskofcarotidplaqueamongleanindividualswithnonalcoholicfattyliverdiseasearetrospectivestudy AT liangshao higherriskofcarotidplaqueamongleanindividualswithnonalcoholicfattyliverdiseasearetrospectivestudy AT huiwangzhang higherriskofcarotidplaqueamongleanindividualswithnonalcoholicfattyliverdiseasearetrospectivestudy AT yeweifeng higherriskofcarotidplaqueamongleanindividualswithnonalcoholicfattyliverdiseasearetrospectivestudy AT pingshuai higherriskofcarotidplaqueamongleanindividualswithnonalcoholicfattyliverdiseasearetrospectivestudy |