Trends in liver cancer rehabilitation needs, disease burden, and attributable risk factors in China, 1990–2021
Abstract This study investigates trends in liver cancer rehabilitation needs, disease burden, and attributable risk factors in China from 1990 to 2021 using data from the Global Burden of Disease Study 2021. Key metrics included age-standardized prevalence (ASPR), years lived with disability (YLDs),...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-00317-7 |
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| author | Xiangping Han Lei He Shaoying Li Yuxing Zhu |
| author_facet | Xiangping Han Lei He Shaoying Li Yuxing Zhu |
| author_sort | Xiangping Han |
| collection | DOAJ |
| description | Abstract This study investigates trends in liver cancer rehabilitation needs, disease burden, and attributable risk factors in China from 1990 to 2021 using data from the Global Burden of Disease Study 2021. Key metrics included age-standardized prevalence (ASPR), years lived with disability (YLDs), and risk factor attribution. Between 1990 and 2021, the number of liver cancer patients requiring rehabilitation surged by 100.1% (132,779 to 265,539 cases), with YLDs rising by 102.8% (22,981 to 46,602). While ASPR and age-standardized YLD rates (ASYR) showed modest declines (ASPR: − 0.1% annual change; ASYR: − 0.23%), males exhibited a disproportionately higher burden, with 2021 cases and YLDs 2.98- and 2.74-fold greater than females, respectively. Risk factor analysis revealed smoking (14.0%), drug use (11.5%), and alcohol consumption (11.4%) as primary contributors, while metabolic factors like high BMI (7.5%) and fasting plasma glucose (1.9%) demonstrated accelerating impacts (YLDs EAPC: + 4.47% and + 1.31%, respectively). Aging populations and shifting etiologies drove increased rehabilitation demands, particularly among those ≥ 80 years. These findings underscore urgent needs for gender-specific interventions targeting modifiable risks and integrated nursing rehabilitation strategies to mitigate China’s growing liver cancer burden. |
| format | Article |
| id | doaj-art-5baeecb75bba4b1085faad3ffd986a85 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-5baeecb75bba4b1085faad3ffd986a852025-08-20T03:09:35ZengNature PortfolioScientific Reports2045-23222025-05-0115111110.1038/s41598-025-00317-7Trends in liver cancer rehabilitation needs, disease burden, and attributable risk factors in China, 1990–2021Xiangping Han0Lei He1Shaoying Li2Yuxing Zhu3Department of Oncology II, Zhumadian Central HospitalThird Department of Psychological Medicine, Zhumadian Second People’s HospitalDepartment of Oncology II, Zhumadian Central HospitalThird Department of Psychological Medicine, Zhumadian Second People’s HospitalAbstract This study investigates trends in liver cancer rehabilitation needs, disease burden, and attributable risk factors in China from 1990 to 2021 using data from the Global Burden of Disease Study 2021. Key metrics included age-standardized prevalence (ASPR), years lived with disability (YLDs), and risk factor attribution. Between 1990 and 2021, the number of liver cancer patients requiring rehabilitation surged by 100.1% (132,779 to 265,539 cases), with YLDs rising by 102.8% (22,981 to 46,602). While ASPR and age-standardized YLD rates (ASYR) showed modest declines (ASPR: − 0.1% annual change; ASYR: − 0.23%), males exhibited a disproportionately higher burden, with 2021 cases and YLDs 2.98- and 2.74-fold greater than females, respectively. Risk factor analysis revealed smoking (14.0%), drug use (11.5%), and alcohol consumption (11.4%) as primary contributors, while metabolic factors like high BMI (7.5%) and fasting plasma glucose (1.9%) demonstrated accelerating impacts (YLDs EAPC: + 4.47% and + 1.31%, respectively). Aging populations and shifting etiologies drove increased rehabilitation demands, particularly among those ≥ 80 years. These findings underscore urgent needs for gender-specific interventions targeting modifiable risks and integrated nursing rehabilitation strategies to mitigate China’s growing liver cancer burden.https://doi.org/10.1038/s41598-025-00317-7Liver cancerRehabilitation needsNursingDisease burdenRisk factorsTrends |
| spellingShingle | Xiangping Han Lei He Shaoying Li Yuxing Zhu Trends in liver cancer rehabilitation needs, disease burden, and attributable risk factors in China, 1990–2021 Scientific Reports Liver cancer Rehabilitation needs Nursing Disease burden Risk factors Trends |
| title | Trends in liver cancer rehabilitation needs, disease burden, and attributable risk factors in China, 1990–2021 |
| title_full | Trends in liver cancer rehabilitation needs, disease burden, and attributable risk factors in China, 1990–2021 |
| title_fullStr | Trends in liver cancer rehabilitation needs, disease burden, and attributable risk factors in China, 1990–2021 |
| title_full_unstemmed | Trends in liver cancer rehabilitation needs, disease burden, and attributable risk factors in China, 1990–2021 |
| title_short | Trends in liver cancer rehabilitation needs, disease burden, and attributable risk factors in China, 1990–2021 |
| title_sort | trends in liver cancer rehabilitation needs disease burden and attributable risk factors in china 1990 2021 |
| topic | Liver cancer Rehabilitation needs Nursing Disease burden Risk factors Trends |
| url | https://doi.org/10.1038/s41598-025-00317-7 |
| work_keys_str_mv | AT xiangpinghan trendsinlivercancerrehabilitationneedsdiseaseburdenandattributableriskfactorsinchina19902021 AT leihe trendsinlivercancerrehabilitationneedsdiseaseburdenandattributableriskfactorsinchina19902021 AT shaoyingli trendsinlivercancerrehabilitationneedsdiseaseburdenandattributableriskfactorsinchina19902021 AT yuxingzhu trendsinlivercancerrehabilitationneedsdiseaseburdenandattributableriskfactorsinchina19902021 |