Analysis of Insulin in Human Breast Milk in Mothers with Type 1 and Type 2 Diabetes Mellitus
Despite the important role that insulin plays in the human body, very little is known about its presence in human milk. Levels rapidly decrease during the first few days of lactation and then, unlike other serum proteins of similar size, achieve comparable levels to those in serum. Despite this, cur...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/296368 |
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| author | T. J. Whitmore N. J. Trengove D. F. Graham P. E. Hartmann |
| author_facet | T. J. Whitmore N. J. Trengove D. F. Graham P. E. Hartmann |
| author_sort | T. J. Whitmore |
| collection | DOAJ |
| description | Despite the important role that insulin plays in the human body, very little is known about its presence in human milk. Levels rapidly decrease during the first few days of lactation and then, unlike other serum proteins of similar size, achieve comparable levels to those in serum. Despite this, current guides for medical treatment suggest that insulin does not pass into milk, raising the question of where the insulin in milk originates. Five mothers without diabetes, 4 mothers with type 1, and 5 mothers with type 2 diabetes collected milk samples over a 24-hour period. Samples were analysed for total and endogenous insulin content and for c-peptide content. All of the insulin present in the milk of type 1 mothers was artificial, and c-peptide levels were 100x lower than in serum. This demonstrates that insulin is transported into human milk at comparable concentration to serum, suggesting an active transport mechanism. The role of insulin in milk is yet to be determined; however, there are a number of potential implications for the infant of the presence of artificial insulins in milk. |
| format | Article |
| id | doaj-art-5ba9ee17c9814a058cdf978cbad8f4cf |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-5ba9ee17c9814a058cdf978cbad8f4cf2025-08-20T03:34:26ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/296368296368Analysis of Insulin in Human Breast Milk in Mothers with Type 1 and Type 2 Diabetes MellitusT. J. Whitmore0N. J. Trengove1D. F. Graham2P. E. Hartmann3Biochemistry and Molecular Biology, School of Biomedical and Chemical Sciences, Faculty of Life and Physical Sciences, The University of Western Australia, UWA M310, 35 Stirling Highway, Crawley, WA 6009, AustraliaBiochemistry and Molecular Biology, School of Biomedical and Chemical Sciences, Faculty of Life and Physical Sciences, The University of Western Australia, UWA M310, 35 Stirling Highway, Crawley, WA 6009, AustraliaBiochemistry and Molecular Biology, School of Biomedical and Chemical Sciences, Faculty of Life and Physical Sciences, The University of Western Australia, UWA M310, 35 Stirling Highway, Crawley, WA 6009, AustraliaBiochemistry and Molecular Biology, School of Biomedical and Chemical Sciences, Faculty of Life and Physical Sciences, The University of Western Australia, UWA M310, 35 Stirling Highway, Crawley, WA 6009, AustraliaDespite the important role that insulin plays in the human body, very little is known about its presence in human milk. Levels rapidly decrease during the first few days of lactation and then, unlike other serum proteins of similar size, achieve comparable levels to those in serum. Despite this, current guides for medical treatment suggest that insulin does not pass into milk, raising the question of where the insulin in milk originates. Five mothers without diabetes, 4 mothers with type 1, and 5 mothers with type 2 diabetes collected milk samples over a 24-hour period. Samples were analysed for total and endogenous insulin content and for c-peptide content. All of the insulin present in the milk of type 1 mothers was artificial, and c-peptide levels were 100x lower than in serum. This demonstrates that insulin is transported into human milk at comparable concentration to serum, suggesting an active transport mechanism. The role of insulin in milk is yet to be determined; however, there are a number of potential implications for the infant of the presence of artificial insulins in milk.http://dx.doi.org/10.1155/2012/296368 |
| spellingShingle | T. J. Whitmore N. J. Trengove D. F. Graham P. E. Hartmann Analysis of Insulin in Human Breast Milk in Mothers with Type 1 and Type 2 Diabetes Mellitus International Journal of Endocrinology |
| title | Analysis of Insulin in Human Breast Milk in Mothers with Type 1 and Type 2 Diabetes Mellitus |
| title_full | Analysis of Insulin in Human Breast Milk in Mothers with Type 1 and Type 2 Diabetes Mellitus |
| title_fullStr | Analysis of Insulin in Human Breast Milk in Mothers with Type 1 and Type 2 Diabetes Mellitus |
| title_full_unstemmed | Analysis of Insulin in Human Breast Milk in Mothers with Type 1 and Type 2 Diabetes Mellitus |
| title_short | Analysis of Insulin in Human Breast Milk in Mothers with Type 1 and Type 2 Diabetes Mellitus |
| title_sort | analysis of insulin in human breast milk in mothers with type 1 and type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2012/296368 |
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