Primary hepatic leiomyosarcoma concurrent with early-stage lung adenocarcinoma: a rare case report
Primary hepatic leiomyosarcoma (PHL) is an extremely rare malignant mesenchymal tumor, accounting for less than 2% of all primary hepatic malignancies. We report a case of a 46-year-old female who presented with a one-year history of abdominal distension and pain. Imaging revealed a 6×5×4 cm mass in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1621686/full |
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| author | Weizhong Peng Xiaohui Xiao Lu Li Yi Yu |
| author_facet | Weizhong Peng Xiaohui Xiao Lu Li Yi Yu |
| author_sort | Weizhong Peng |
| collection | DOAJ |
| description | Primary hepatic leiomyosarcoma (PHL) is an extremely rare malignant mesenchymal tumor, accounting for less than 2% of all primary hepatic malignancies. We report a case of a 46-year-old female who presented with a one-year history of abdominal distension and pain. Imaging revealed a 6×5×4 cm mass in the left hepatic lobe (segments 3/4) and incidentally detected a suspicious pulmonary nodule. Laparoscopic partial left hepatectomy followed by thoracoscopic wedge resection of the left upper lung confirmed the diagnoses of primary hepatic leiomyosarcoma and primary lung adenocarcinoma (cT1aN0M0), respectively. This case highlights the importance of comprehensive diagnostics, immunohistochemical analysis, and multidisciplinary management of rare hepatic tumors, particularly when concurrent malignancies are present. This first reported case of concurrent PHL and primary lung adenocarcinoma provides valuable insights for clinical practice in managing patients with rare hepatic malignancies. |
| format | Article |
| id | doaj-art-5ba5b533aca247249f92e7f8568e909e |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-5ba5b533aca247249f92e7f8568e909e2025-08-20T02:38:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-07-011510.3389/fonc.2025.16216861621686Primary hepatic leiomyosarcoma concurrent with early-stage lung adenocarcinoma: a rare case reportWeizhong Peng0Xiaohui Xiao1Lu Li2Yi Yu3Hepatobiliary Surgery, The First People’s Hospital of Chenzhou City, Chenzhou, Hunan, ChinaDepartment of Ultrasound, Xiangnan University Affiliated Hospital, Chenzhou, Hunan, ChinaPathology Department, The First People’s Hospital of Chenzhou City, Chenzhou, Hunan, ChinaHepatobiliary Surgery, The First People’s Hospital of Chenzhou City, Chenzhou, Hunan, ChinaPrimary hepatic leiomyosarcoma (PHL) is an extremely rare malignant mesenchymal tumor, accounting for less than 2% of all primary hepatic malignancies. We report a case of a 46-year-old female who presented with a one-year history of abdominal distension and pain. Imaging revealed a 6×5×4 cm mass in the left hepatic lobe (segments 3/4) and incidentally detected a suspicious pulmonary nodule. Laparoscopic partial left hepatectomy followed by thoracoscopic wedge resection of the left upper lung confirmed the diagnoses of primary hepatic leiomyosarcoma and primary lung adenocarcinoma (cT1aN0M0), respectively. This case highlights the importance of comprehensive diagnostics, immunohistochemical analysis, and multidisciplinary management of rare hepatic tumors, particularly when concurrent malignancies are present. This first reported case of concurrent PHL and primary lung adenocarcinoma provides valuable insights for clinical practice in managing patients with rare hepatic malignancies.https://www.frontiersin.org/articles/10.3389/fonc.2025.1621686/fullprimary hepatic leiomyosarcomalung adenocarcinomasynchronous primary malignanciesliver neoplasmsmultidisciplinary management |
| spellingShingle | Weizhong Peng Xiaohui Xiao Lu Li Yi Yu Primary hepatic leiomyosarcoma concurrent with early-stage lung adenocarcinoma: a rare case report Frontiers in Oncology primary hepatic leiomyosarcoma lung adenocarcinoma synchronous primary malignancies liver neoplasms multidisciplinary management |
| title | Primary hepatic leiomyosarcoma concurrent with early-stage lung adenocarcinoma: a rare case report |
| title_full | Primary hepatic leiomyosarcoma concurrent with early-stage lung adenocarcinoma: a rare case report |
| title_fullStr | Primary hepatic leiomyosarcoma concurrent with early-stage lung adenocarcinoma: a rare case report |
| title_full_unstemmed | Primary hepatic leiomyosarcoma concurrent with early-stage lung adenocarcinoma: a rare case report |
| title_short | Primary hepatic leiomyosarcoma concurrent with early-stage lung adenocarcinoma: a rare case report |
| title_sort | primary hepatic leiomyosarcoma concurrent with early stage lung adenocarcinoma a rare case report |
| topic | primary hepatic leiomyosarcoma lung adenocarcinoma synchronous primary malignancies liver neoplasms multidisciplinary management |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1621686/full |
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