High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes
Abstract Aims To assess the association between serum uric acid (SUA) level and the prevalence of diabetic retinopathy (DR) and chronic kidney disease (CKD) in patients with long-term diabetes. Methods A cross-sectional analysis was conducted involving diabetic patients from Shanghai General hospita...
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BMC
2025-03-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-025-01656-1 |
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| author | Hanying Wang Liping Gu Yuhang Ma Xindan Xing Yuan Qu Xin Shi Xinyi Liu Hancong Wan Qian Zhu Yingchen Shen Chong Chen Li Su Yufan Wang Kun Liu |
| author_facet | Hanying Wang Liping Gu Yuhang Ma Xindan Xing Yuan Qu Xin Shi Xinyi Liu Hancong Wan Qian Zhu Yingchen Shen Chong Chen Li Su Yufan Wang Kun Liu |
| author_sort | Hanying Wang |
| collection | DOAJ |
| description | Abstract Aims To assess the association between serum uric acid (SUA) level and the prevalence of diabetic retinopathy (DR) and chronic kidney disease (CKD) in patients with long-term diabetes. Methods A cross-sectional analysis was conducted involving diabetic patients from Shanghai General hospital during October 2018 and October 2021. Participants underwent measurements of SUA, renal function test and DR assessments via fundus photography. Multivariable ordinal logistic regression models assessed odd ratios (ORs) and 95% confidence intervals (95% CIs) for the progression of DR and CKD. Receiver operating characteristics (ROC) curves identified SUA thresholds, categorizing participants into low and high SUA groups. Results Among the 1015 patients with diabetes, SUA levels were higher in individuals with advanced CKD stages (p < 0.001, compared with stage 1 CKD) and vision-threatening diabetic retinopathy (VTDR) (p = 0.019, compared with no diabetic retinopathy (NDR)). In multivariable models adjusted for potential confounders, higher SUA levels were associated with an increased risk of DR (OR: 1.002, 95% CI: 1.001–1.004) and CKD (OR: 1.008, 95% CI: 1.006–1.011). Notably, SUA levels exceeding 354.0 µmol/L (95% CI: 318.9–393.2) and 361.0 µmol/L (339.2–386.3) were associated with 1.571-fold (95% CI: 1.139–2.099, P = 0.006 for DR) and 1.395-fold (95% CI: 1.033–1.885, P = 0.030 for CKD) increased risks, respectively. Gender-specific analyses also demonstrated a positive correlation between higher SUA levels and the incidence of DR and CKD in both males and females. Conclusions Elevated SUA levels are independently coincided with increased risks of DR and CKD, suggesting that SUA may serve as a potential risk marker for diabetic complications. |
| format | Article |
| id | doaj-art-5ba5809e6e7f4a85a23bd06d86e79fbb |
| institution | Kabale University |
| issn | 1758-5996 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-5ba5809e6e7f4a85a23bd06d86e79fbb2025-08-20T03:40:48ZengBMCDiabetology & Metabolic Syndrome1758-59962025-03-0117111010.1186/s13098-025-01656-1High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetesHanying Wang0Liping Gu1Yuhang Ma2Xindan Xing3Yuan Qu4Xin Shi5Xinyi Liu6Hancong Wan7Qian Zhu8Yingchen Shen9Chong Chen10Li Su11Yufan Wang12Kun Liu13Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye DiseasesDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye DiseasesDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye DiseasesDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye DiseasesDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye DiseasesDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye DiseasesDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye DiseasesDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye DiseasesDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye DiseasesDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye DiseasesDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye DiseasesAbstract Aims To assess the association between serum uric acid (SUA) level and the prevalence of diabetic retinopathy (DR) and chronic kidney disease (CKD) in patients with long-term diabetes. Methods A cross-sectional analysis was conducted involving diabetic patients from Shanghai General hospital during October 2018 and October 2021. Participants underwent measurements of SUA, renal function test and DR assessments via fundus photography. Multivariable ordinal logistic regression models assessed odd ratios (ORs) and 95% confidence intervals (95% CIs) for the progression of DR and CKD. Receiver operating characteristics (ROC) curves identified SUA thresholds, categorizing participants into low and high SUA groups. Results Among the 1015 patients with diabetes, SUA levels were higher in individuals with advanced CKD stages (p < 0.001, compared with stage 1 CKD) and vision-threatening diabetic retinopathy (VTDR) (p = 0.019, compared with no diabetic retinopathy (NDR)). In multivariable models adjusted for potential confounders, higher SUA levels were associated with an increased risk of DR (OR: 1.002, 95% CI: 1.001–1.004) and CKD (OR: 1.008, 95% CI: 1.006–1.011). Notably, SUA levels exceeding 354.0 µmol/L (95% CI: 318.9–393.2) and 361.0 µmol/L (339.2–386.3) were associated with 1.571-fold (95% CI: 1.139–2.099, P = 0.006 for DR) and 1.395-fold (95% CI: 1.033–1.885, P = 0.030 for CKD) increased risks, respectively. Gender-specific analyses also demonstrated a positive correlation between higher SUA levels and the incidence of DR and CKD in both males and females. Conclusions Elevated SUA levels are independently coincided with increased risks of DR and CKD, suggesting that SUA may serve as a potential risk marker for diabetic complications.https://doi.org/10.1186/s13098-025-01656-1Serum uric acidDiabetic retinopathyChronic kidney diseaseDiabetes mellitus |
| spellingShingle | Hanying Wang Liping Gu Yuhang Ma Xindan Xing Yuan Qu Xin Shi Xinyi Liu Hancong Wan Qian Zhu Yingchen Shen Chong Chen Li Su Yufan Wang Kun Liu High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes Diabetology & Metabolic Syndrome Serum uric acid Diabetic retinopathy Chronic kidney disease Diabetes mellitus |
| title | High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes |
| title_full | High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes |
| title_fullStr | High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes |
| title_full_unstemmed | High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes |
| title_short | High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes |
| title_sort | high levels of serum uric acid are associated with microvascular complications in patients with long term diabetes |
| topic | Serum uric acid Diabetic retinopathy Chronic kidney disease Diabetes mellitus |
| url | https://doi.org/10.1186/s13098-025-01656-1 |
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