Preliminary Assessment of the Chemical Stability of Dried Extracts from Guazuma ulmifolia Lam. (Sterculiaceae)
We report the results of a preliminary estimation of the stability of the dried extract from bark of Guazuma ulmifolia Lam. (“Mutamba”), with and without added colloidal silicon dioxide (CSD). The physical and chemical properties and the compatibility of CSD in the extract were evaluated for 21 days...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/508945 |
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| author | Gisely C. Lopes Renata Longhini Paulo Victor P. dos Santos Adriano A. S. Araújo Marcos Luciano Bruschi João Carlos P. de Mello |
| author_facet | Gisely C. Lopes Renata Longhini Paulo Victor P. dos Santos Adriano A. S. Araújo Marcos Luciano Bruschi João Carlos P. de Mello |
| author_sort | Gisely C. Lopes |
| collection | DOAJ |
| description | We report the results of a preliminary estimation of the stability of the dried extract from bark of Guazuma ulmifolia Lam. (“Mutamba”), with and without added colloidal silicon dioxide (CSD). The physical and chemical properties and the compatibility of CSD in the extract were evaluated for 21 days of storage under stress conditions of temperature (45±2°C) and humidity (75±5%). Thermogravimetry (TG) was supplemented using selective high-performance liquid chromatography (HPLC) for determination of stability of the characteristic constituents (chemical markers), namely, procyanidin B2 (PB2) and epicatechin (EP). The results showed that PB2 is an appropriate compound to be used as a chemical marker in the quality control of dried extracts of G. ulmifolia. The stress study showed that there was no significant difference between the two formulations. However, considering the TG data and the high temperatures involved, the results suggest that CSD increases the stability of the dried extract of G. ulmifolia. |
| format | Article |
| id | doaj-art-5b9d179b75aa451ba51db6edfcbf8124 |
| institution | Kabale University |
| issn | 1687-8760 1687-8779 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-5b9d179b75aa451ba51db6edfcbf81242025-02-03T01:11:36ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792012-01-01201210.1155/2012/508945508945Preliminary Assessment of the Chemical Stability of Dried Extracts from Guazuma ulmifolia Lam. (Sterculiaceae)Gisely C. Lopes0Renata Longhini1Paulo Victor P. dos Santos2Adriano A. S. Araújo3Marcos Luciano Bruschi4João Carlos P. de Mello5Programa de Pós-Graduação em Ciências Farmacêuticas, Departamento de Farmácia, Universidade Estadual de Maringá, Avenida Colombo, 5790, 87020-900 Maringá, PR, BrazilPrograma de Pós-Graduação em Ciências Farmacêuticas, Departamento de Farmácia, Universidade Estadual de Maringá, Avenida Colombo, 5790, 87020-900 Maringá, PR, BrazilStudent of Pharmacy, Universidade Estadual de Maringá, Avenida Colombo, 5790, 87020-900 Maringá, PR, BrazilDepartamento de Fisiologia, Universidade Federal de Sergipe, Avenida Marechal Rondon, s/n, Cidade Universitária, 49100-000 São Cristóvão, SE, BrazilPrograma de Pós-Graduação em Ciências Farmacêuticas, Departamento de Farmácia, Universidade Estadual de Maringá, Avenida Colombo, 5790, 87020-900 Maringá, PR, BrazilPrograma de Pós-Graduação em Ciências Farmacêuticas, Departamento de Farmácia, Universidade Estadual de Maringá, Avenida Colombo, 5790, 87020-900 Maringá, PR, BrazilWe report the results of a preliminary estimation of the stability of the dried extract from bark of Guazuma ulmifolia Lam. (“Mutamba”), with and without added colloidal silicon dioxide (CSD). The physical and chemical properties and the compatibility of CSD in the extract were evaluated for 21 days of storage under stress conditions of temperature (45±2°C) and humidity (75±5%). Thermogravimetry (TG) was supplemented using selective high-performance liquid chromatography (HPLC) for determination of stability of the characteristic constituents (chemical markers), namely, procyanidin B2 (PB2) and epicatechin (EP). The results showed that PB2 is an appropriate compound to be used as a chemical marker in the quality control of dried extracts of G. ulmifolia. The stress study showed that there was no significant difference between the two formulations. However, considering the TG data and the high temperatures involved, the results suggest that CSD increases the stability of the dried extract of G. ulmifolia.http://dx.doi.org/10.1155/2012/508945 |
| spellingShingle | Gisely C. Lopes Renata Longhini Paulo Victor P. dos Santos Adriano A. S. Araújo Marcos Luciano Bruschi João Carlos P. de Mello Preliminary Assessment of the Chemical Stability of Dried Extracts from Guazuma ulmifolia Lam. (Sterculiaceae) International Journal of Analytical Chemistry |
| title | Preliminary Assessment of the Chemical Stability of Dried Extracts from Guazuma ulmifolia Lam. (Sterculiaceae) |
| title_full | Preliminary Assessment of the Chemical Stability of Dried Extracts from Guazuma ulmifolia Lam. (Sterculiaceae) |
| title_fullStr | Preliminary Assessment of the Chemical Stability of Dried Extracts from Guazuma ulmifolia Lam. (Sterculiaceae) |
| title_full_unstemmed | Preliminary Assessment of the Chemical Stability of Dried Extracts from Guazuma ulmifolia Lam. (Sterculiaceae) |
| title_short | Preliminary Assessment of the Chemical Stability of Dried Extracts from Guazuma ulmifolia Lam. (Sterculiaceae) |
| title_sort | preliminary assessment of the chemical stability of dried extracts from guazuma ulmifolia lam sterculiaceae |
| url | http://dx.doi.org/10.1155/2012/508945 |
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