Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research
Myasthenia gravis (MG) is an autoimmune disorder involving complex interactions between genetic and environmental factors. Genome-wide association studies (GWAS), transcriptome-wide association studies (TWAS), and other methods have identified multiple novel susceptibility loci and genes, providing...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1508422/full |
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| author | Zheng Yixian Wang Hai Liu Xiuying Yan Jichun |
| author_facet | Zheng Yixian Wang Hai Liu Xiuying Yan Jichun |
| author_sort | Zheng Yixian |
| collection | DOAJ |
| description | Myasthenia gravis (MG) is an autoimmune disorder involving complex interactions between genetic and environmental factors. Genome-wide association studies (GWAS), transcriptome-wide association studies (TWAS), and other methods have identified multiple novel susceptibility loci and genes, providing crucial insights into the genetic etiology of MG. Moreover, the pivotal roles of epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs, in the pathogenesis of MG are gradually being unveiled. This review comprehensively summarizes the latest advances in MG genetic research, focusing on the discovery and validation of susceptibility genes, genetic heterogeneity and subtype-specific genetic factors, gene–environment interactions, epigenetic mechanisms, and progress in genetics-based diagnostic and prognostic biomarkers. |
| format | Article |
| id | doaj-art-5b9a0a1284c346768ec83c2702231b5f |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-5b9a0a1284c346768ec83c2702231b5f2025-01-07T06:40:36ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15084221508422Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience researchZheng Yixian0Wang Hai1Liu Xiuying2Yan Jichun3Zhangpu County Hospital, Zhangzhou, Fujian, ChinaYue Bei People's Hospital, Shaoguan, ChinaThe First People's Hospital of Qinzhou, Qinzhou, ChinaGanzhou City People's Hospital, Ganzhou, Jiangxi, ChinaMyasthenia gravis (MG) is an autoimmune disorder involving complex interactions between genetic and environmental factors. Genome-wide association studies (GWAS), transcriptome-wide association studies (TWAS), and other methods have identified multiple novel susceptibility loci and genes, providing crucial insights into the genetic etiology of MG. Moreover, the pivotal roles of epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs, in the pathogenesis of MG are gradually being unveiled. This review comprehensively summarizes the latest advances in MG genetic research, focusing on the discovery and validation of susceptibility genes, genetic heterogeneity and subtype-specific genetic factors, gene–environment interactions, epigenetic mechanisms, and progress in genetics-based diagnostic and prognostic biomarkers.https://www.frontiersin.org/articles/10.3389/fmed.2024.1508422/fullmyasthenia gravisgenetic susceptibilitygenome-wide association studytranscriptome-wide association studyepigenetic mechanisms |
| spellingShingle | Zheng Yixian Wang Hai Liu Xiuying Yan Jichun Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research Frontiers in Medicine myasthenia gravis genetic susceptibility genome-wide association study transcriptome-wide association study epigenetic mechanisms |
| title | Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research |
| title_full | Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research |
| title_fullStr | Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research |
| title_full_unstemmed | Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research |
| title_short | Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research |
| title_sort | advances in the genetics of myasthenia gravis insights from cutting edge neuroscience research |
| topic | myasthenia gravis genetic susceptibility genome-wide association study transcriptome-wide association study epigenetic mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1508422/full |
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