Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013–2016
People are continually and simultaneously exposed to various non-persistent pesticides as these chemicals are ubiquitously distributed in the environment. Toxicological studies have indicated the associations between non-persistent pesticides and liver fibrosis in vitro and in vivo. However, epidemi...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325001125 |
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| author | Shuge Shu Yuan Li Xiangyu Yu Xinting Chen Ummara Abdullah Yongquan Yu |
| author_facet | Shuge Shu Yuan Li Xiangyu Yu Xinting Chen Ummara Abdullah Yongquan Yu |
| author_sort | Shuge Shu |
| collection | DOAJ |
| description | People are continually and simultaneously exposed to various non-persistent pesticides as these chemicals are ubiquitously distributed in the environment. Toxicological studies have indicated the associations between non-persistent pesticides and liver fibrosis in vitro and in vivo. However, epidemical study on the deleterious effect of non-persistent pesticides on the risk of liver fibrosis is rather limited. To examine the relationship between mixed non-persistent pesticides exposure and liver fibrosis, and to identify the potential pesticides of significant importance, this study enrolled the representative individuals from the NHANES 2013–2016 survey cycles, in which urinary non-persistent pesticides were measured. Liver fibrosis was determined based on the alternative noninvasive tests Fibrosis-4 index (FIB-4) and Hepamet Fibrosis Score (HFS). Survey-weighted linear/logistic regression and Bayesian kernel machine regression (BKMR) were used to detected the independent and combined associations between non-persistent pesticides and liver fibrosis, respectively. In single exposure analysis, significant and persistent associations were identified for 3,5,6-trichloropyridinol (TCPY), para-nitrophenol (PNP), glyphosate (GLYP) and 2,4-dichlorophenoxyacetic acid (2,4-D) exposure with both continuous and dichotomous liver fibrosis outcomes. Of them, TCPY and GLYP had the highest effect estimates, with the corresponding FIB-4 coefficient (β) being 0.09 (0.05–0.13, model 3) and 0.09 (0.06–0.12, model 3), respectively. In BKMR analysis, positive associations between pesticides mixture and FIB-4 and HFS liver fibrosis were identified. The results of Posterior Inclusion Probability (PIP) further showed that GLYP, TCPY, and PNP were the main contributors to the overall effects of pesticides mixture, and the corresponding PIPs were 1.000 (1.000), 1.000 (0.914) and 0.972 (0.819) for FIB-4 (HFS) liver fibrosis, respectively. This study indicates that exposure to non-persistent pesticides mixture is associated with increased risk of liver fibrosis in humans, and provide new insight into the hepatotoxic potential of non-persistent pesticides. |
| format | Article |
| id | doaj-art-5b98168ccd754e70b4e9d4c6517c5da9 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-5b98168ccd754e70b4e9d4c6517c5da92025-02-12T05:30:19ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117776Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013–2016Shuge Shu0Yuan Li1Xiangyu Yu2Xinting Chen3Ummara Abdullah4Yongquan Yu5Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, PR ChinaDepartment of Cosmetic Dermatology, The Fifth People’s Hospital of Hainan Province, Haikou 570000, PR ChinaKey Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, PR ChinaKey Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, PR ChinaKey Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, PR ChinaKey Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, PR China; Correspondence to: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu, PR China.People are continually and simultaneously exposed to various non-persistent pesticides as these chemicals are ubiquitously distributed in the environment. Toxicological studies have indicated the associations between non-persistent pesticides and liver fibrosis in vitro and in vivo. However, epidemical study on the deleterious effect of non-persistent pesticides on the risk of liver fibrosis is rather limited. To examine the relationship between mixed non-persistent pesticides exposure and liver fibrosis, and to identify the potential pesticides of significant importance, this study enrolled the representative individuals from the NHANES 2013–2016 survey cycles, in which urinary non-persistent pesticides were measured. Liver fibrosis was determined based on the alternative noninvasive tests Fibrosis-4 index (FIB-4) and Hepamet Fibrosis Score (HFS). Survey-weighted linear/logistic regression and Bayesian kernel machine regression (BKMR) were used to detected the independent and combined associations between non-persistent pesticides and liver fibrosis, respectively. In single exposure analysis, significant and persistent associations were identified for 3,5,6-trichloropyridinol (TCPY), para-nitrophenol (PNP), glyphosate (GLYP) and 2,4-dichlorophenoxyacetic acid (2,4-D) exposure with both continuous and dichotomous liver fibrosis outcomes. Of them, TCPY and GLYP had the highest effect estimates, with the corresponding FIB-4 coefficient (β) being 0.09 (0.05–0.13, model 3) and 0.09 (0.06–0.12, model 3), respectively. In BKMR analysis, positive associations between pesticides mixture and FIB-4 and HFS liver fibrosis were identified. The results of Posterior Inclusion Probability (PIP) further showed that GLYP, TCPY, and PNP were the main contributors to the overall effects of pesticides mixture, and the corresponding PIPs were 1.000 (1.000), 1.000 (0.914) and 0.972 (0.819) for FIB-4 (HFS) liver fibrosis, respectively. This study indicates that exposure to non-persistent pesticides mixture is associated with increased risk of liver fibrosis in humans, and provide new insight into the hepatotoxic potential of non-persistent pesticides.http://www.sciencedirect.com/science/article/pii/S0147651325001125Non-persistent pesticidesLiver fibrosisMixed exposureBKMRJoint effect |
| spellingShingle | Shuge Shu Yuan Li Xiangyu Yu Xinting Chen Ummara Abdullah Yongquan Yu Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013–2016 Ecotoxicology and Environmental Safety Non-persistent pesticides Liver fibrosis Mixed exposure BKMR Joint effect |
| title | Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013–2016 |
| title_full | Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013–2016 |
| title_fullStr | Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013–2016 |
| title_full_unstemmed | Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013–2016 |
| title_short | Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013–2016 |
| title_sort | association between mixed exposure of non persistent pesticides and liver fibrosis in the general us population nhanes 2013 2016 |
| topic | Non-persistent pesticides Liver fibrosis Mixed exposure BKMR Joint effect |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325001125 |
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