Evolutionary history of the DNA repair protein, Ku, in eukaryotes and prokaryotes.

Evolutionary history of the DNA repair protein, Ku, in eukaryotes and prokaryotes.

Ku is essential in non-homologous end-joining (NHEJ) across prokaryotes and eukaryotes, primarily in double-stranded breaks (DSBs) repair. It often presents as a multi-domain protein in eukaryotes, unlike their prokaryotic single-domain homologs. We systematically searched for Ku proteins across dif...

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Bibliographic Details
Main Authors: Sadikshya Rijal, Ashmita Mainali, Sandesh Acharya, Hitesh Kumar Bhattarai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0308593
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