Association between immune cells and allergic purpura: a Mendelian randomization study
Abstract Background Increasing evidence indicates a substantial correlation between the immune cells and the risk of allergic purpura. We utilized Mendelian randomization (MR) to investigate causal effect of immune cell on allergic purpura. Methods Genetic instrumental variables for immune cells wer...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
|
| Series: | Italian Journal of Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13052-025-01847-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850201312055001088 |
|---|---|
| author | Wei Xian Huiyi Zhang Huasong Zeng |
| author_facet | Wei Xian Huiyi Zhang Huasong Zeng |
| author_sort | Wei Xian |
| collection | DOAJ |
| description | Abstract Background Increasing evidence indicates a substantial correlation between the immune cells and the risk of allergic purpura. We utilized Mendelian randomization (MR) to investigate causal effect of immune cell on allergic purpura. Methods Genetic instrumental variables for immune cells were sourced from an extensive genome-wide association study (GWAS) comprising 3757 participants. Summary statistics of allergic purpura, involving 470 cases and 216,099 controls, were obtained from FinnGen. The primary analysis employed the inverse-variance weighted (IVW) method. Rigorous sensitivity analyses including MR-Egger, weighted median and MR-PRESSO were conducted to ensure the reliability of the causal estimate. Results We identified two immunophenotypes associated with an increased risk of allergic purpura: HLA-DR on CD14 + CD16- monocyte (OR: 1.2379; 95% CI: 1.0612–1.4440; P = 0.0066) and CD11b on basophil (OR: 1.2973; 95% CI: 1.0905–1.5433; P = 0.0033). The sensitivity analyses consistently yielded similar results for these immunophenotypes. Conclusions Our analyses confirmed a potential causal effect of HLA-DR on CD14 + CD16- monocyte, as well as CD11b on basophils, in relation to the risk of allergic purpura. Further studies are necessary to clarify the mechanisms by which these immunophenotypes influence the development of allergic purpura. |
| format | Article |
| id | doaj-art-5b95cfe6f7b641e59d38286e6470fa70 |
| institution | OA Journals |
| issn | 1824-7288 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj-art-5b95cfe6f7b641e59d38286e6470fa702025-08-20T02:12:02ZengBMCItalian Journal of Pediatrics1824-72882025-04-015111810.1186/s13052-025-01847-6Association between immune cells and allergic purpura: a Mendelian randomization studyWei Xian0Huiyi Zhang1Huasong Zeng2Department of Pediatric Allergy, Immunology and Rheumatology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversitySun Yat-Sen University School of Medicine, Shenzhen Campus of Sun Yat-sen UniversityDepartment of Pediatric Allergy, Immunology and Rheumatology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityAbstract Background Increasing evidence indicates a substantial correlation between the immune cells and the risk of allergic purpura. We utilized Mendelian randomization (MR) to investigate causal effect of immune cell on allergic purpura. Methods Genetic instrumental variables for immune cells were sourced from an extensive genome-wide association study (GWAS) comprising 3757 participants. Summary statistics of allergic purpura, involving 470 cases and 216,099 controls, were obtained from FinnGen. The primary analysis employed the inverse-variance weighted (IVW) method. Rigorous sensitivity analyses including MR-Egger, weighted median and MR-PRESSO were conducted to ensure the reliability of the causal estimate. Results We identified two immunophenotypes associated with an increased risk of allergic purpura: HLA-DR on CD14 + CD16- monocyte (OR: 1.2379; 95% CI: 1.0612–1.4440; P = 0.0066) and CD11b on basophil (OR: 1.2973; 95% CI: 1.0905–1.5433; P = 0.0033). The sensitivity analyses consistently yielded similar results for these immunophenotypes. Conclusions Our analyses confirmed a potential causal effect of HLA-DR on CD14 + CD16- monocyte, as well as CD11b on basophils, in relation to the risk of allergic purpura. Further studies are necessary to clarify the mechanisms by which these immunophenotypes influence the development of allergic purpura.https://doi.org/10.1186/s13052-025-01847-6Allergic purpuraImmune cellsMendelian randomizationSingle nucleotide polymorphism |
| spellingShingle | Wei Xian Huiyi Zhang Huasong Zeng Association between immune cells and allergic purpura: a Mendelian randomization study Italian Journal of Pediatrics Allergic purpura Immune cells Mendelian randomization Single nucleotide polymorphism |
| title | Association between immune cells and allergic purpura: a Mendelian randomization study |
| title_full | Association between immune cells and allergic purpura: a Mendelian randomization study |
| title_fullStr | Association between immune cells and allergic purpura: a Mendelian randomization study |
| title_full_unstemmed | Association between immune cells and allergic purpura: a Mendelian randomization study |
| title_short | Association between immune cells and allergic purpura: a Mendelian randomization study |
| title_sort | association between immune cells and allergic purpura a mendelian randomization study |
| topic | Allergic purpura Immune cells Mendelian randomization Single nucleotide polymorphism |
| url | https://doi.org/10.1186/s13052-025-01847-6 |
| work_keys_str_mv | AT weixian associationbetweenimmunecellsandallergicpurpuraamendelianrandomizationstudy AT huiyizhang associationbetweenimmunecellsandallergicpurpuraamendelianrandomizationstudy AT huasongzeng associationbetweenimmunecellsandallergicpurpuraamendelianrandomizationstudy |