Prolonged effects of adenoviral vector priming on T-cell cytokine production in heterologous adenoviral vector/mRNA COVID-19 vaccination regimens

Prolonged effects of adenoviral vector priming on T-cell cytokine production in heterologous adenoviral vector/mRNA COVID-19 vaccination regimens

Abstract mRNA and adenoviral vector vaccine platforms were used for the primary series of COVID-19 vaccines in many countries. However, the distinct immunogenic properties on these platforms remain less understood. We traced neutralizing antibodies, memory B cells, and T cells longitudinally in coho...

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Main Authors: Masanori Isogawa, Taishi Onodera, Akira Ainai, Ryutaro Kotaki, Takayuki Kanno, Shinji Saito, Minoru Tobiume, Kenzo Tokunaga, Megumi Hara, Yoshio Hirota, Tadaki Suzuki, Yoshimasa Takahashi, Tomomi Tsuru
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-00054-x
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https://doi.org/10.1038/s41598-025-00054-x

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