Obesity Is an Independent Predictor of Poor Survival in Metastatic Breast Cancer: Retrospective Analysis of a Patient Cohort Whose Treatment Included High-Dose Chemotherapy and Autologous Stem Cell Support
The purpose of the study was to identify predictors of long-term survival in metastatic breast cancer (MBC). A cohort of 96 patients, who received high-dose chemotherapy with autologous stem cell support (HD-ASCT) as part of their treatment, was analyzed. Percent long-term survival at 10 years was...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.4061/2011/523276 |
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| author | A. von Drygalski T. B. Tran K. Messer M. Pu S. Corringham C. Nelson E. D. Ball |
| author_facet | A. von Drygalski T. B. Tran K. Messer M. Pu S. Corringham C. Nelson E. D. Ball |
| author_sort | A. von Drygalski |
| collection | DOAJ |
| description | The purpose of the study was to identify predictors of long-term survival in metastatic breast cancer (MBC). A cohort of 96 patients, who received high-dose chemotherapy with autologous stem cell support (HD-ASCT) as part of their treatment, was analyzed. Percent long-term survival at 10 years was
24.5% (CI 17.2–34.9%) when metastasis was diagnosed and 14.4% (CI 8.7–23.9%) when MBC was diagnosed. Survival was impacted significantly by body mass index (BMI). Median overall survival from initial diagnosis or from time of metastasis for patients with BMIs
≤30 and >30 (obese) was 7.1 (CI 4.4–8.7) and 3.2 years (2.41–6.75), respectively, or 3.2 or 2.3 years (all 𝑃=0.02). Also, obesity was the only independent patient-related predictor of time to metastasis and of survival. While obesity is linked with poor outcomes in earlier stages of breast cancer, this has not been previously reported for MBC. |
| format | Article |
| id | doaj-art-5b8d553914a34a2c9dabaa705c5f44f7 |
| institution | Kabale University |
| issn | 2090-3189 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-5b8d553914a34a2c9dabaa705c5f44f72025-08-20T03:35:00ZengWileyInternational Journal of Breast Cancer2090-31892011-01-01201110.4061/2011/523276523276Obesity Is an Independent Predictor of Poor Survival in Metastatic Breast Cancer: Retrospective Analysis of a Patient Cohort Whose Treatment Included High-Dose Chemotherapy and Autologous Stem Cell SupportA. von Drygalski0T. B. Tran1K. Messer2M. Pu3S. Corringham4C. Nelson5E. D. Ball6Division of Hematology/Oncology, Department of Medicine, UCSD, CA 92093, USADivision of Hematology/Oncology, Department of Medicine, UCSD, CA 92093, USADivision of Biostatistics and Bioinformatics, Department of Family and Preventive Medicine, UCSD, CA 92093, USADivision of Biostatistics and Bioinformatics, Department of Family and Preventive Medicine, UCSD, CA 92093, USADivision of Bone and Marrow Transplantation, Department of Medicine, UCSD, CA 92093, USADivision of Bone and Marrow Transplantation, Department of Medicine, UCSD, CA 92093, USADivision of Bone and Marrow Transplantation, Department of Medicine, UCSD, CA 92093, USAThe purpose of the study was to identify predictors of long-term survival in metastatic breast cancer (MBC). A cohort of 96 patients, who received high-dose chemotherapy with autologous stem cell support (HD-ASCT) as part of their treatment, was analyzed. Percent long-term survival at 10 years was 24.5% (CI 17.2–34.9%) when metastasis was diagnosed and 14.4% (CI 8.7–23.9%) when MBC was diagnosed. Survival was impacted significantly by body mass index (BMI). Median overall survival from initial diagnosis or from time of metastasis for patients with BMIs ≤30 and >30 (obese) was 7.1 (CI 4.4–8.7) and 3.2 years (2.41–6.75), respectively, or 3.2 or 2.3 years (all 𝑃=0.02). Also, obesity was the only independent patient-related predictor of time to metastasis and of survival. While obesity is linked with poor outcomes in earlier stages of breast cancer, this has not been previously reported for MBC.http://dx.doi.org/10.4061/2011/523276 |
| spellingShingle | A. von Drygalski T. B. Tran K. Messer M. Pu S. Corringham C. Nelson E. D. Ball Obesity Is an Independent Predictor of Poor Survival in Metastatic Breast Cancer: Retrospective Analysis of a Patient Cohort Whose Treatment Included High-Dose Chemotherapy and Autologous Stem Cell Support International Journal of Breast Cancer |
| title | Obesity Is an Independent Predictor of Poor Survival in Metastatic Breast Cancer: Retrospective Analysis of a Patient Cohort Whose Treatment Included High-Dose Chemotherapy and Autologous Stem Cell Support |
| title_full | Obesity Is an Independent Predictor of Poor Survival in Metastatic Breast Cancer: Retrospective Analysis of a Patient Cohort Whose Treatment Included High-Dose Chemotherapy and Autologous Stem Cell Support |
| title_fullStr | Obesity Is an Independent Predictor of Poor Survival in Metastatic Breast Cancer: Retrospective Analysis of a Patient Cohort Whose Treatment Included High-Dose Chemotherapy and Autologous Stem Cell Support |
| title_full_unstemmed | Obesity Is an Independent Predictor of Poor Survival in Metastatic Breast Cancer: Retrospective Analysis of a Patient Cohort Whose Treatment Included High-Dose Chemotherapy and Autologous Stem Cell Support |
| title_short | Obesity Is an Independent Predictor of Poor Survival in Metastatic Breast Cancer: Retrospective Analysis of a Patient Cohort Whose Treatment Included High-Dose Chemotherapy and Autologous Stem Cell Support |
| title_sort | obesity is an independent predictor of poor survival in metastatic breast cancer retrospective analysis of a patient cohort whose treatment included high dose chemotherapy and autologous stem cell support |
| url | http://dx.doi.org/10.4061/2011/523276 |
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