Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s disease

Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β plaques, tau hyperphosphorylation, and neuroinflammation. The choroid plexus (ChP), serving as the blood-cerebrospinal fluid-brain barrier, plays essential roles in...

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Bibliographic Details
Main Authors: Zhong-Jiang Yan, Maosen Ye, Jiexi Li, Deng-Feng Zhang, Yong-Gang Yao
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Choroid plexus
Single-cell transcriptome
Lipid accumulation
Neuroinflammation
Online Access:https://doi.org/10.1186/s13024-025-00853-w
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