Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in an elderly population
Abstract Aging reduces functional capacity, decreasing lean mass and immune function, possibly impacting the intestinal morphofunctional barrier. This study aimed to characterize intestinal permeability in an elderly population and its association with anthropometric and biochemical variables associ...
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| Format: | Article |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-08045-8 |
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| author | Maria Clara da Cruz Carvalho Ana Carolina Costa Campos Mota Daniele de Souza Marinho do Nascimento Ingrid Naihara França de Sousa Mariana Duarte Bona Karla Danielly da Silva Ribeiro Aldo Ângelo Moreira Lima Bruna Leal Lima Maciel |
| author_facet | Maria Clara da Cruz Carvalho Ana Carolina Costa Campos Mota Daniele de Souza Marinho do Nascimento Ingrid Naihara França de Sousa Mariana Duarte Bona Karla Danielly da Silva Ribeiro Aldo Ângelo Moreira Lima Bruna Leal Lima Maciel |
| author_sort | Maria Clara da Cruz Carvalho |
| collection | DOAJ |
| description | Abstract Aging reduces functional capacity, decreasing lean mass and immune function, possibly impacting the intestinal morphofunctional barrier. This study aimed to characterize intestinal permeability in an elderly population and its association with anthropometric and biochemical variables associated with cardiovascular risk. A cross-sectional study was conducted with 54 elderly individuals from Oct/19-Mar/23. Self-reported disease, anthropometric (weight, height, waist, and hip circumferences), and biochemical (lipid profile, glycemic, and serum retinol) data were collected. Intestinal permeability was assessed using the lactulose: mannitol (L: M) test, and stratified into percentile ≤ 50 or > 50. Diabetes, hypertension, and overweight were present in 25.9%, 53.7%, and 51.9% of the population, with no significant differences between those with L: M ≤ P50 or > P50. Median L: M was 0.037 (0.014; 0.060). Those with L: M > P50 had significantly lower levels of hip circumference [96.50 (93; 104) cm; P = 0.041] and serum retinol [0.95 (0.60; 1.16) mmol/L; P < 0.001], and these variables were also inversely associated with an odds for a L: M > P50 (AOR 0.93, 95% CI 0.86–0.99; P = 0.042; AOR 0.15, 95% CI 0.05–0.42; P < 0.001, respectively). We concluded that hip circumference and serum retinol were negatively associated with intestinal permeability in the studied elderly, and data indicate that lactulose and mannitol were positively associated with anthropometric and biochemical markers related to metabolic complications. |
| format | Article |
| id | doaj-art-5b880f4980bc4f46a2a2a39674254be2 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-5b880f4980bc4f46a2a2a39674254be22025-08-20T03:45:26ZengNature PortfolioScientific Reports2045-23222025-07-011511910.1038/s41598-025-08045-8Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in an elderly populationMaria Clara da Cruz Carvalho0Ana Carolina Costa Campos Mota1Daniele de Souza Marinho do Nascimento2Ingrid Naihara França de Sousa3Mariana Duarte Bona4Karla Danielly da Silva Ribeiro5Aldo Ângelo Moreira Lima6Bruna Leal Lima Maciel7Post Graduate Program in Health Sciences, Center for Health Sciences, Federal University of Rio Grande do NortePost Graduate Program in Nutrition, Department of Nutrition, Federal University of Rio Grande do NortePost Graduate Program in Health Sciences, Center for Health Sciences, Federal University of Rio Grande do NorteDepartment of Nutrition, Center for Health Science, Federal University of Rio Grande do NorteInstitute of Biomedicine, Department of Medicine, Federal University of CearaPost Graduate Program in Nutrition, Department of Nutrition, Federal University of Rio Grande do NorteInstitute of Biomedicine, Department of Medicine, Federal University of CearaPost Graduate Program in Health Sciences, Center for Health Sciences, Federal University of Rio Grande do NorteAbstract Aging reduces functional capacity, decreasing lean mass and immune function, possibly impacting the intestinal morphofunctional barrier. This study aimed to characterize intestinal permeability in an elderly population and its association with anthropometric and biochemical variables associated with cardiovascular risk. A cross-sectional study was conducted with 54 elderly individuals from Oct/19-Mar/23. Self-reported disease, anthropometric (weight, height, waist, and hip circumferences), and biochemical (lipid profile, glycemic, and serum retinol) data were collected. Intestinal permeability was assessed using the lactulose: mannitol (L: M) test, and stratified into percentile ≤ 50 or > 50. Diabetes, hypertension, and overweight were present in 25.9%, 53.7%, and 51.9% of the population, with no significant differences between those with L: M ≤ P50 or > P50. Median L: M was 0.037 (0.014; 0.060). Those with L: M > P50 had significantly lower levels of hip circumference [96.50 (93; 104) cm; P = 0.041] and serum retinol [0.95 (0.60; 1.16) mmol/L; P < 0.001], and these variables were also inversely associated with an odds for a L: M > P50 (AOR 0.93, 95% CI 0.86–0.99; P = 0.042; AOR 0.15, 95% CI 0.05–0.42; P < 0.001, respectively). We concluded that hip circumference and serum retinol were negatively associated with intestinal permeability in the studied elderly, and data indicate that lactulose and mannitol were positively associated with anthropometric and biochemical markers related to metabolic complications.https://doi.org/10.1038/s41598-025-08045-8Intestinal permeabilityElderly healthVitamin A |
| spellingShingle | Maria Clara da Cruz Carvalho Ana Carolina Costa Campos Mota Daniele de Souza Marinho do Nascimento Ingrid Naihara França de Sousa Mariana Duarte Bona Karla Danielly da Silva Ribeiro Aldo Ângelo Moreira Lima Bruna Leal Lima Maciel Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in an elderly population Scientific Reports Intestinal permeability Elderly health Vitamin A |
| title | Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in an elderly population |
| title_full | Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in an elderly population |
| title_fullStr | Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in an elderly population |
| title_full_unstemmed | Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in an elderly population |
| title_short | Intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in an elderly population |
| title_sort | intestinal permeability and its relation to anthropometric and biochemical variables associated with cardiovascular risk in an elderly population |
| topic | Intestinal permeability Elderly health Vitamin A |
| url | https://doi.org/10.1038/s41598-025-08045-8 |
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