Research Progress in Lactoferrin’s Role in Alleviating Intestinal Barrier Dysfunction
The intestinal barrier plays a crucial role in maintaining homeostasis in the body. When the intestinal mucosa is damaged, the tight junctions between intestinal cells are disrupted, and the intestinal flora becomes imbalanced, a variety of diseases can arise. Natural active proteins are pivotal in...
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China Food Publishing Company
2025-01-01
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| Series: | Shipin Kexue |
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| Online Access: | https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-2-035.pdf |
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| author | LI Yi, REN Xinxin, WANG Qin, HE Xiaoyun |
| author_facet | LI Yi, REN Xinxin, WANG Qin, HE Xiaoyun |
| author_sort | LI Yi, REN Xinxin, WANG Qin, HE Xiaoyun |
| collection | DOAJ |
| description | The intestinal barrier plays a crucial role in maintaining homeostasis in the body. When the intestinal mucosa is damaged, the tight junctions between intestinal cells are disrupted, and the intestinal flora becomes imbalanced, a variety of diseases can arise. Natural active proteins are pivotal in the repair of the intestinal barrier. Lactoferrin, a glycoprotein abundant in mammalian milk, exhibits a range of biological functions such as antioxidant, anti-inflammatory and antibacterial functions. Numerous studies have shown that lactoferrin elevates the levels of intestinal tight junction proteins, promotes the growth and development of intestinal cells, down-regulates the expression of inflammatory factors, regulates the immune response and intestinal microbial diversity, and contributes to the maintenance of intestinal barrier homeostasis. In this paper, a review on the alleviation of intestinal barrier dysfunction by lactoferrin is conducted, aiming to gain a better understanding of the mechanisms underlying lactoferrin’s role in alleviating intestinal injury and to provide insights for the development of lactoferrin-based interventions in intestinal diseases. |
| format | Article |
| id | doaj-art-5b86efd6828e4c4b9d6ccc7f054b3fd8 |
| institution | Kabale University |
| issn | 1002-6630 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | China Food Publishing Company |
| record_format | Article |
| series | Shipin Kexue |
| spelling | doaj-art-5b86efd6828e4c4b9d6ccc7f054b3fd82025-02-05T09:08:23ZengChina Food Publishing CompanyShipin Kexue1002-66302025-01-0146231732610.7506/spkx1002-6630-20231113-100Research Progress in Lactoferrin’s Role in Alleviating Intestinal Barrier DysfunctionLI Yi, REN Xinxin, WANG Qin, HE Xiaoyun0(1. College of Food Science &Nutritional Engineering, China Agricultural University, Beijing 100083, China;2. College of Animal Science and Technology, China Agricultural University, Beijing 100083, China)The intestinal barrier plays a crucial role in maintaining homeostasis in the body. When the intestinal mucosa is damaged, the tight junctions between intestinal cells are disrupted, and the intestinal flora becomes imbalanced, a variety of diseases can arise. Natural active proteins are pivotal in the repair of the intestinal barrier. Lactoferrin, a glycoprotein abundant in mammalian milk, exhibits a range of biological functions such as antioxidant, anti-inflammatory and antibacterial functions. Numerous studies have shown that lactoferrin elevates the levels of intestinal tight junction proteins, promotes the growth and development of intestinal cells, down-regulates the expression of inflammatory factors, regulates the immune response and intestinal microbial diversity, and contributes to the maintenance of intestinal barrier homeostasis. In this paper, a review on the alleviation of intestinal barrier dysfunction by lactoferrin is conducted, aiming to gain a better understanding of the mechanisms underlying lactoferrin’s role in alleviating intestinal injury and to provide insights for the development of lactoferrin-based interventions in intestinal diseases.https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-2-035.pdflactoferrin; intestinal barrier; physiological activity; gut microorganisms |
| spellingShingle | LI Yi, REN Xinxin, WANG Qin, HE Xiaoyun Research Progress in Lactoferrin’s Role in Alleviating Intestinal Barrier Dysfunction Shipin Kexue lactoferrin; intestinal barrier; physiological activity; gut microorganisms |
| title | Research Progress in Lactoferrin’s Role in Alleviating Intestinal Barrier Dysfunction |
| title_full | Research Progress in Lactoferrin’s Role in Alleviating Intestinal Barrier Dysfunction |
| title_fullStr | Research Progress in Lactoferrin’s Role in Alleviating Intestinal Barrier Dysfunction |
| title_full_unstemmed | Research Progress in Lactoferrin’s Role in Alleviating Intestinal Barrier Dysfunction |
| title_short | Research Progress in Lactoferrin’s Role in Alleviating Intestinal Barrier Dysfunction |
| title_sort | research progress in lactoferrin s role in alleviating intestinal barrier dysfunction |
| topic | lactoferrin; intestinal barrier; physiological activity; gut microorganisms |
| url | https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-2-035.pdf |
| work_keys_str_mv | AT liyirenxinxinwangqinhexiaoyun researchprogressinlactoferrinsroleinalleviatingintestinalbarrierdysfunction |