Grammatophyllum speciosum Ethanolic Extract Promotes Wound Healing in Human Primary Fibroblast Cells
Grammatophyllum speciosum is a plant in Orchidaceae family which contains a variety of phytochemical compounds that might be beneficial for medicinal use. This study aimed to evaluate the activity of pseudobulb of G. speciosum extract (GSE) in wound healing processes in human primary fibroblast cell...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2018/7836869 |
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| _version_ | 1832552564457996288 |
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| author | Saraporn Harikarnpakdee Verisa Chowjarean |
| author_facet | Saraporn Harikarnpakdee Verisa Chowjarean |
| author_sort | Saraporn Harikarnpakdee |
| collection | DOAJ |
| description | Grammatophyllum speciosum is a plant in Orchidaceae family which contains a variety of phytochemical compounds that might be beneficial for medicinal use. This study aimed to evaluate the activity of pseudobulb of G. speciosum extract (GSE) in wound healing processes in human primary fibroblast cells along with in vitro antioxidant activity and total phenolic content of GSE. Scratch wound healing assay indicated that GSE was capable of increasing migration rate after 6 and 9 hours of treatment. Besides, the extract was able to scavenge DPPH, ABTS, and superoxide anion radicals indicating the antioxidative property of GSE. This study suggested a novel role of the of pseudobulb extract of G. speciosum as a wound healing enhancer. The results from this study might be beneficial for the development of further novel active compounds for skin wound healing. |
| format | Article |
| id | doaj-art-5b85831b2c004a05916afd2b5b98ee83 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-5b85831b2c004a05916afd2b5b98ee832025-02-03T05:58:18ZengWileyInternational Journal of Cell Biology1687-88761687-88842018-01-01201810.1155/2018/78368697836869Grammatophyllum speciosum Ethanolic Extract Promotes Wound Healing in Human Primary Fibroblast CellsSaraporn Harikarnpakdee0Verisa Chowjarean1Cosmeceutical Research, Development and Testing Center, College of Pharmacy, Rangsit University, Pathum Thani 12000, ThailandCosmeceutical Research, Development and Testing Center, College of Pharmacy, Rangsit University, Pathum Thani 12000, ThailandGrammatophyllum speciosum is a plant in Orchidaceae family which contains a variety of phytochemical compounds that might be beneficial for medicinal use. This study aimed to evaluate the activity of pseudobulb of G. speciosum extract (GSE) in wound healing processes in human primary fibroblast cells along with in vitro antioxidant activity and total phenolic content of GSE. Scratch wound healing assay indicated that GSE was capable of increasing migration rate after 6 and 9 hours of treatment. Besides, the extract was able to scavenge DPPH, ABTS, and superoxide anion radicals indicating the antioxidative property of GSE. This study suggested a novel role of the of pseudobulb extract of G. speciosum as a wound healing enhancer. The results from this study might be beneficial for the development of further novel active compounds for skin wound healing.http://dx.doi.org/10.1155/2018/7836869 |
| spellingShingle | Saraporn Harikarnpakdee Verisa Chowjarean Grammatophyllum speciosum Ethanolic Extract Promotes Wound Healing in Human Primary Fibroblast Cells International Journal of Cell Biology |
| title | Grammatophyllum speciosum Ethanolic Extract Promotes Wound Healing in Human Primary Fibroblast Cells |
| title_full | Grammatophyllum speciosum Ethanolic Extract Promotes Wound Healing in Human Primary Fibroblast Cells |
| title_fullStr | Grammatophyllum speciosum Ethanolic Extract Promotes Wound Healing in Human Primary Fibroblast Cells |
| title_full_unstemmed | Grammatophyllum speciosum Ethanolic Extract Promotes Wound Healing in Human Primary Fibroblast Cells |
| title_short | Grammatophyllum speciosum Ethanolic Extract Promotes Wound Healing in Human Primary Fibroblast Cells |
| title_sort | grammatophyllum speciosum ethanolic extract promotes wound healing in human primary fibroblast cells |
| url | http://dx.doi.org/10.1155/2018/7836869 |
| work_keys_str_mv | AT sarapornharikarnpakdee grammatophyllumspeciosumethanolicextractpromoteswoundhealinginhumanprimaryfibroblastcells AT verisachowjarean grammatophyllumspeciosumethanolicextractpromoteswoundhealinginhumanprimaryfibroblastcells |