Atrioventricular Conduction Delay in the Second Trimester Measured by Fetal Magnetocardiography
Introduction. Fetal AV block in SSA/Ro pregnancies is generally not seen before 18-week gestation and onset is rare after 28-week gestation. If complete AV block appears, it is believed to be irreversible. The purpose of the study was to evaluate precise electrophysiological AV conduction from 18-we...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/753953 |
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| author | Annette Wacker-Gussmann Henrike Paulsen Krunoslav Stingl Johanna Braendle Rangmar Goelz Joerg Henes |
| author_facet | Annette Wacker-Gussmann Henrike Paulsen Krunoslav Stingl Johanna Braendle Rangmar Goelz Joerg Henes |
| author_sort | Annette Wacker-Gussmann |
| collection | DOAJ |
| description | Introduction. Fetal AV block in SSA/Ro pregnancies is generally not seen before 18-week gestation and onset is rare after 28-week gestation. If complete AV block appears, it is believed to be irreversible. The purpose of the study was to evaluate precise electrophysiological AV conduction from 18-week gestation onwards. Patients and Methods. 21 fetuses of pregnant women with collagen vascular diseases were included in the study group and 59 healthy fetuses served as controls. In addition to fetal echocardiography, fetal magnetocardiography (fMCG) was used to investigate precise electrophysiological fetal cardiac time intervals (fCTIs). Results. The PR segment (isoelectric segment between the end of the P wave and the start of the QRS complex) was significantly prolonged (P<0.036 2nd trimester, P<0.023 3rd trimester) in both trimesters within the study group. In fetuses less than 23-week gestational age, a nearly complete separation was found, where a PR segment of 60 ms or greater completely excluded control fetuses. All other fCTIs did not differ significantly. None of the fetuses progressed to a more advanced heart block. Conclusion. Slight antibody effects in pregnancy, leading to PR segment prolongation, can already be seen from 18-week gestation onwards by fMCG. Serial fetal Doppler echocardiography and additional fMCG can be useful methods to measure early and precise AV conduction time, to achieve best surveillance for these high-risk pregnancies. |
| format | Article |
| id | doaj-art-5b822a1fea84477c9e055a8b252194a1 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | Journal of Immunology Research |
| spelling | doaj-art-5b822a1fea84477c9e055a8b252194a12025-02-03T00:59:21ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/753953753953Atrioventricular Conduction Delay in the Second Trimester Measured by Fetal MagnetocardiographyAnnette Wacker-Gussmann0Henrike Paulsen1Krunoslav Stingl2Johanna Braendle3Rangmar Goelz4Joerg Henes5Department of Neonatology, University Children’s Hospital Tuebingen, 72076 Tuebingen, GermanyDepartment of Neonatology, University Children’s Hospital Tuebingen, 72076 Tuebingen, GermanyDepartment of Neonatology, University Children’s Hospital Tuebingen, 72076 Tuebingen, GermanyDepartment of Obstetrics and Gynecology, University Hospital, 72076 Tuebingen, GermanyDepartment of Neonatology, University Children’s Hospital Tuebingen, 72076 Tuebingen, GermanyCentre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-Inflammatory Diseases and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital, 72076 Tuebingen, GermanyIntroduction. Fetal AV block in SSA/Ro pregnancies is generally not seen before 18-week gestation and onset is rare after 28-week gestation. If complete AV block appears, it is believed to be irreversible. The purpose of the study was to evaluate precise electrophysiological AV conduction from 18-week gestation onwards. Patients and Methods. 21 fetuses of pregnant women with collagen vascular diseases were included in the study group and 59 healthy fetuses served as controls. In addition to fetal echocardiography, fetal magnetocardiography (fMCG) was used to investigate precise electrophysiological fetal cardiac time intervals (fCTIs). Results. The PR segment (isoelectric segment between the end of the P wave and the start of the QRS complex) was significantly prolonged (P<0.036 2nd trimester, P<0.023 3rd trimester) in both trimesters within the study group. In fetuses less than 23-week gestational age, a nearly complete separation was found, where a PR segment of 60 ms or greater completely excluded control fetuses. All other fCTIs did not differ significantly. None of the fetuses progressed to a more advanced heart block. Conclusion. Slight antibody effects in pregnancy, leading to PR segment prolongation, can already be seen from 18-week gestation onwards by fMCG. Serial fetal Doppler echocardiography and additional fMCG can be useful methods to measure early and precise AV conduction time, to achieve best surveillance for these high-risk pregnancies.http://dx.doi.org/10.1155/2014/753953 |
| spellingShingle | Annette Wacker-Gussmann Henrike Paulsen Krunoslav Stingl Johanna Braendle Rangmar Goelz Joerg Henes Atrioventricular Conduction Delay in the Second Trimester Measured by Fetal Magnetocardiography Journal of Immunology Research |
| title | Atrioventricular Conduction Delay in the Second Trimester Measured by Fetal Magnetocardiography |
| title_full | Atrioventricular Conduction Delay in the Second Trimester Measured by Fetal Magnetocardiography |
| title_fullStr | Atrioventricular Conduction Delay in the Second Trimester Measured by Fetal Magnetocardiography |
| title_full_unstemmed | Atrioventricular Conduction Delay in the Second Trimester Measured by Fetal Magnetocardiography |
| title_short | Atrioventricular Conduction Delay in the Second Trimester Measured by Fetal Magnetocardiography |
| title_sort | atrioventricular conduction delay in the second trimester measured by fetal magnetocardiography |
| url | http://dx.doi.org/10.1155/2014/753953 |
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