Prediction of clinically significant recurrence after partial nephrectomy. Data from the Cancer Registry of Norway with more than five years of follow-up
Objective: To determine recurrence incidence after partial nephrectomy (PN) for renal cell carcinoma and identify predictors for local recurrence (LR) and metastasis. Material and methods: We retrospectively evaluated a cohort of 524 patients from the Cancer Registry of Norway, who underwent PN bet...
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Medical journals sweden AB
2024-01-01
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| Series: | Scandinavian Journal of Urology |
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| Online Access: | https://medicaljournalssweden.se/SJU/article/view/18674 |
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| author | Ovidiu S. Barnoiu Tom B. Johannesen Lien M. Diep Eskil S. Pedersen Karin M. Hjelle Christian Beisland |
| author_facet | Ovidiu S. Barnoiu Tom B. Johannesen Lien M. Diep Eskil S. Pedersen Karin M. Hjelle Christian Beisland |
| author_sort | Ovidiu S. Barnoiu |
| collection | DOAJ |
| description | Objective: To determine recurrence incidence after partial nephrectomy (PN) for renal cell carcinoma and identify predictors for local recurrence (LR) and metastasis.
Material and methods: We retrospectively evaluated a cohort of 524 patients from the Cancer Registry of Norway, who underwent PN between January 2014 and December 2015 and were followed-up for >6 years. Patient demographics and pathological characteristics were correlated with recurrence and progression-free survival using Kaplan-Meier and Cox regression analyses.
Results: Median patient age was 64 years, and the median tumour size was 2.6 cm. A positive surgical margin (PSM) was observed in 11% of the cases, while the LR and metastasis rates were 3.4% and 3.2%, respectively. PSM (hazard ratio [HR], 55.4; 95% confidence interval [CI], 12.55–244.6), tumour number (HR, 45.4; 95% CI, 6.5–316.1) and stage (HR, 33.5; 95% CI, 5.4–205.3) were independent predictors for LR. Undetermined margin status was also a risk factor for LR. Tumour stage (HR, 41.05; 95% CI, 8.52–197.76), tumour necrosis (HR, 1.3; 95% CI, 0.4–4.31) and age (HR, 1.07; 95% CI, 1.01–1.14) were predictors for metastasis.
Conclusions: Both local and distant recurrences after PN were rare, and the pT stage was a common predictor. PSM or indeterminate surgical margin and tumour number were LR predictors, while age at surgery and the presence of tumour necrosis predicted metastasis.
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| format | Article |
| id | doaj-art-5b7bf030522d44efa46869c27e1bae85 |
| institution | DOAJ |
| issn | 2168-1813 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Medical journals sweden AB |
| record_format | Article |
| series | Scandinavian Journal of Urology |
| spelling | doaj-art-5b7bf030522d44efa46869c27e1bae852025-08-20T03:12:35ZengMedical journals sweden ABScandinavian Journal of Urology2168-18132024-01-015910.2340/sju.v59.18674Prediction of clinically significant recurrence after partial nephrectomy. Data from the Cancer Registry of Norway with more than five years of follow-upOvidiu S. Barnoiu0https://orcid.org/0000-0003-3347-1645Tom B. Johannesen1Lien M. Diep2Eskil S. Pedersen3Karin M. Hjelle4Christian Beisland5Department of Urology, Sorlandet Hospital, Kristiansand, NorwayCancer Registry of Norway, Oslo, NorwayOCBE, Research Support Services, Oslo University Hospital, Oslo, NorwayDepartment of Urology, Sorlandet Hospital, Kristiansand, NorwayDepartment of Urology, Haukeland University Hospital, Bergen, NorwayDepartment of Urology, Haukeland University Hospital, Bergen, NorwayObjective: To determine recurrence incidence after partial nephrectomy (PN) for renal cell carcinoma and identify predictors for local recurrence (LR) and metastasis. Material and methods: We retrospectively evaluated a cohort of 524 patients from the Cancer Registry of Norway, who underwent PN between January 2014 and December 2015 and were followed-up for >6 years. Patient demographics and pathological characteristics were correlated with recurrence and progression-free survival using Kaplan-Meier and Cox regression analyses. Results: Median patient age was 64 years, and the median tumour size was 2.6 cm. A positive surgical margin (PSM) was observed in 11% of the cases, while the LR and metastasis rates were 3.4% and 3.2%, respectively. PSM (hazard ratio [HR], 55.4; 95% confidence interval [CI], 12.55–244.6), tumour number (HR, 45.4; 95% CI, 6.5–316.1) and stage (HR, 33.5; 95% CI, 5.4–205.3) were independent predictors for LR. Undetermined margin status was also a risk factor for LR. Tumour stage (HR, 41.05; 95% CI, 8.52–197.76), tumour necrosis (HR, 1.3; 95% CI, 0.4–4.31) and age (HR, 1.07; 95% CI, 1.01–1.14) were predictors for metastasis. Conclusions: Both local and distant recurrences after PN were rare, and the pT stage was a common predictor. PSM or indeterminate surgical margin and tumour number were LR predictors, while age at surgery and the presence of tumour necrosis predicted metastasis. https://medicaljournalssweden.se/SJU/article/view/18674local recurrencemetastasispartial nephrectomypredictive modelRenal Cell Carcinoma |
| spellingShingle | Ovidiu S. Barnoiu Tom B. Johannesen Lien M. Diep Eskil S. Pedersen Karin M. Hjelle Christian Beisland Prediction of clinically significant recurrence after partial nephrectomy. Data from the Cancer Registry of Norway with more than five years of follow-up Scandinavian Journal of Urology local recurrence metastasis partial nephrectomy predictive model Renal Cell Carcinoma |
| title | Prediction of clinically significant recurrence after partial nephrectomy. Data from the Cancer Registry of Norway with more than five years of follow-up |
| title_full | Prediction of clinically significant recurrence after partial nephrectomy. Data from the Cancer Registry of Norway with more than five years of follow-up |
| title_fullStr | Prediction of clinically significant recurrence after partial nephrectomy. Data from the Cancer Registry of Norway with more than five years of follow-up |
| title_full_unstemmed | Prediction of clinically significant recurrence after partial nephrectomy. Data from the Cancer Registry of Norway with more than five years of follow-up |
| title_short | Prediction of clinically significant recurrence after partial nephrectomy. Data from the Cancer Registry of Norway with more than five years of follow-up |
| title_sort | prediction of clinically significant recurrence after partial nephrectomy data from the cancer registry of norway with more than five years of follow up |
| topic | local recurrence metastasis partial nephrectomy predictive model Renal Cell Carcinoma |
| url | https://medicaljournalssweden.se/SJU/article/view/18674 |
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