Prediction of clinically significant recurrence after partial nephrectomy. Data from the Cancer Registry of Norway with more than five years of follow-up
Objective: To determine recurrence incidence after partial nephrectomy (PN) for renal cell carcinoma and identify predictors for local recurrence (LR) and metastasis. Material and methods: We retrospectively evaluated a cohort of 524 patients from the Cancer Registry of Norway, who underwent PN bet...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Medical journals sweden AB
2024-01-01
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| Series: | Scandinavian Journal of Urology |
| Subjects: | |
| Online Access: | https://medicaljournalssweden.se/SJU/article/view/18674 |
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| Summary: | Objective: To determine recurrence incidence after partial nephrectomy (PN) for renal cell carcinoma and identify predictors for local recurrence (LR) and metastasis.
Material and methods: We retrospectively evaluated a cohort of 524 patients from the Cancer Registry of Norway, who underwent PN between January 2014 and December 2015 and were followed-up for >6 years. Patient demographics and pathological characteristics were correlated with recurrence and progression-free survival using Kaplan-Meier and Cox regression analyses.
Results: Median patient age was 64 years, and the median tumour size was 2.6 cm. A positive surgical margin (PSM) was observed in 11% of the cases, while the LR and metastasis rates were 3.4% and 3.2%, respectively. PSM (hazard ratio [HR], 55.4; 95% confidence interval [CI], 12.55–244.6), tumour number (HR, 45.4; 95% CI, 6.5–316.1) and stage (HR, 33.5; 95% CI, 5.4–205.3) were independent predictors for LR. Undetermined margin status was also a risk factor for LR. Tumour stage (HR, 41.05; 95% CI, 8.52–197.76), tumour necrosis (HR, 1.3; 95% CI, 0.4–4.31) and age (HR, 1.07; 95% CI, 1.01–1.14) were predictors for metastasis.
Conclusions: Both local and distant recurrences after PN were rare, and the pT stage was a common predictor. PSM or indeterminate surgical margin and tumour number were LR predictors, while age at surgery and the presence of tumour necrosis predicted metastasis.
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| ISSN: | 2168-1813 |