Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease

Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease

Abstract Isoliquiritigenin (ISL), a flavone isolated from licorice, has been demonstrated to exhibit anti-inflammatory and antioxidant properties in the treatment of Alzheimer’s disease (AD). However, the molecular details of the contribution of ISL to AD remain largely elusive. The present study ai...

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Bibliographic Details
Main Authors: Waimao Gao, Guang Yang, Xinjuan Liu, Kaifan Hu, Jie Pan, Xingyu Wang, Yan Zhao, Ying Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Isoliquiritigenin
Alzheimer’s disease
Network pharmacology
ERK/PPAR-γ pathway
Neuroinflammation
BV2 microglial cells
Online Access:https://doi.org/10.1038/s41598-025-88542-y
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