Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage
Bone marrow stromal cells (BMSCs) may differentiate into nerve cells under a certain condition; however, the clinical application for treating nervous system disease remains unclear. The aim is to assess the safety profile, feasibility, and effectiveness of surgery combined with autologous BMSCs tra...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/318269 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552850186567680 |
|---|---|
| author | Jianxin Zhu Yilei Xiao Zhongmin Li Fabin Han Taiwu Xiao Zhiti Zhang Fengyang Geng |
| author_facet | Jianxin Zhu Yilei Xiao Zhongmin Li Fabin Han Taiwu Xiao Zhiti Zhang Fengyang Geng |
| author_sort | Jianxin Zhu |
| collection | DOAJ |
| description | Bone marrow stromal cells (BMSCs) may differentiate into nerve cells under a certain condition; however, the clinical application for treating nervous system disease remains unclear. The aim is to assess the safety profile, feasibility, and effectiveness of surgery combined with autologous BMSCs transplantation for treating ICH. 206 ICH patients who had received surgical procedure were divided into transplantation (n=110) or control group (n=96). For transplantation group, BMSCs were injected into the perihemorrhage area in the base ganglia through an intracranial drainage tube 5.5 (3.01–6.89) days after surgery, followed by a second injection into the subarachnoid space through lumbar puncture 4 weeks later. Neurologic impairment and daily activities were assessed with National Institute Stroke Scale (NIHSS), Barthel index, and Rankin scale before transplantation and 6 months and 12 months after transplantation. Our results revealed that, compared with control group, NIHSS score and Rankin scale were both significantly decreased but Barthel index was increased in transplantation group after 6 months. Interestingly, no significant difference was observed between 12 months and 6 months. No transplantation-related adverse effects were investigated during follow-up assessments. Our findings suggest that surgery combined with autologous BMSCs transplantation is safe for treatment of ICH, providing short-term therapeutic benefits. |
| format | Article |
| id | doaj-art-5b7604dc891d49f9baeb26251803aa76 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5b7604dc891d49f9baeb26251803aa762025-02-03T05:57:39ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/318269318269Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral HemorrhageJianxin Zhu0Yilei Xiao1Zhongmin Li2Fabin Han3Taiwu Xiao4Zhiti Zhang5Fengyang Geng6Department of Neurosurgery, Liaocheng People’s Hospital of Taishan Medical University, Liaocheng 252000, ChinaDepartment of Neurosurgery, Liaocheng People’s Hospital of Taishan Medical University, Liaocheng 252000, ChinaDepartment of Neurosurgery, Liaocheng People’s Hospital of Taishan Medical University, Liaocheng 252000, ChinaNeurological Laboratory, Liaocheng People’s Hospital of Taishan Medical University, Liaocheng 252000, ChinaDepartment of Hematology, Liaocheng People’s Hospital of Taishan Medical University, Liaocheng 252000, ChinaDepartment of Neurosurgery, Liaocheng People’s Hospital of Taishan Medical University, Liaocheng 252000, ChinaDepartment of Neurosurgery, Liaocheng People’s Hospital of Taishan Medical University, Liaocheng 252000, ChinaBone marrow stromal cells (BMSCs) may differentiate into nerve cells under a certain condition; however, the clinical application for treating nervous system disease remains unclear. The aim is to assess the safety profile, feasibility, and effectiveness of surgery combined with autologous BMSCs transplantation for treating ICH. 206 ICH patients who had received surgical procedure were divided into transplantation (n=110) or control group (n=96). For transplantation group, BMSCs were injected into the perihemorrhage area in the base ganglia through an intracranial drainage tube 5.5 (3.01–6.89) days after surgery, followed by a second injection into the subarachnoid space through lumbar puncture 4 weeks later. Neurologic impairment and daily activities were assessed with National Institute Stroke Scale (NIHSS), Barthel index, and Rankin scale before transplantation and 6 months and 12 months after transplantation. Our results revealed that, compared with control group, NIHSS score and Rankin scale were both significantly decreased but Barthel index was increased in transplantation group after 6 months. Interestingly, no significant difference was observed between 12 months and 6 months. No transplantation-related adverse effects were investigated during follow-up assessments. Our findings suggest that surgery combined with autologous BMSCs transplantation is safe for treatment of ICH, providing short-term therapeutic benefits.http://dx.doi.org/10.1155/2015/318269 |
| spellingShingle | Jianxin Zhu Yilei Xiao Zhongmin Li Fabin Han Taiwu Xiao Zhiti Zhang Fengyang Geng Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage Stem Cells International |
| title | Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage |
| title_full | Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage |
| title_fullStr | Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage |
| title_full_unstemmed | Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage |
| title_short | Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage |
| title_sort | efficacy of surgery combined with autologous bone marrow stromal cell transplantation for treatment of intracerebral hemorrhage |
| url | http://dx.doi.org/10.1155/2015/318269 |
| work_keys_str_mv | AT jianxinzhu efficacyofsurgerycombinedwithautologousbonemarrowstromalcelltransplantationfortreatmentofintracerebralhemorrhage AT yileixiao efficacyofsurgerycombinedwithautologousbonemarrowstromalcelltransplantationfortreatmentofintracerebralhemorrhage AT zhongminli efficacyofsurgerycombinedwithautologousbonemarrowstromalcelltransplantationfortreatmentofintracerebralhemorrhage AT fabinhan efficacyofsurgerycombinedwithautologousbonemarrowstromalcelltransplantationfortreatmentofintracerebralhemorrhage AT taiwuxiao efficacyofsurgerycombinedwithautologousbonemarrowstromalcelltransplantationfortreatmentofintracerebralhemorrhage AT zhitizhang efficacyofsurgerycombinedwithautologousbonemarrowstromalcelltransplantationfortreatmentofintracerebralhemorrhage AT fengyanggeng efficacyofsurgerycombinedwithautologousbonemarrowstromalcelltransplantationfortreatmentofintracerebralhemorrhage |