Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies
The expression and function of the receptor are controlled by epigenetic changes, such as DNA methylation, histone modification, and noncoding RNAs. These modifications play a pivotal role in receptor activity and can lead to or exacerbate endocrine-related diseases. This review examines the epigene...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-07-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304224002782 |
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| author | Yixin Song Kexin Zhang Jingwen Zhang Qinying Li Na Huang Yujie Ma Ningning Hou Fang Han Chengxia Kan Xiaodong Sun |
| author_facet | Yixin Song Kexin Zhang Jingwen Zhang Qinying Li Na Huang Yujie Ma Ningning Hou Fang Han Chengxia Kan Xiaodong Sun |
| author_sort | Yixin Song |
| collection | DOAJ |
| description | The expression and function of the receptor are controlled by epigenetic changes, such as DNA methylation, histone modification, and noncoding RNAs. These modifications play a pivotal role in receptor activity and can lead to or exacerbate endocrine-related diseases. This review examines the epigenetic alterations of nuclear receptors and their significant impact on conditions such as diabetes, thyroid disorders, and endocrine-related tumors. It highlights current therapies targeting these epigenetic mechanisms, including gene editing, epigenetic drugs, and various other therapeutic approaches. This review offers fresh insight into the mechanisms of endocrine-associated disorders, highlighting the latest progress in the development of novel epigenetic therapies that can be used to address receptor–endocrine interactions. |
| format | Article |
| id | doaj-art-5b754bc2bf3447639c9bcf225b8a6779 |
| institution | Kabale University |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-5b754bc2bf3447639c9bcf225b8a67792025-08-20T03:52:33ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-07-0112410148110.1016/j.gendis.2024.101481Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategiesYixin Song0Kexin Zhang1Jingwen Zhang2Qinying Li3Na Huang4Yujie Ma5Ningning Hou6Fang Han7Chengxia Kan8Xiaodong Sun9Department of Endocrinology and Metabolism, Clinical Research Center, Shandong Provincial Key Medical and Health Discipline of Endocrinology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, ChinaDepartment of Endocrinology and Metabolism, Clinical Research Center, Shandong Provincial Key Medical and Health Discipline of Endocrinology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, ChinaDepartment of Endocrinology and Metabolism, Clinical Research Center, Shandong Provincial Key Medical and Health Discipline of Endocrinology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, ChinaDepartment of Endocrinology and Metabolism, Clinical Research Center, Shandong Provincial Key Medical and Health Discipline of Endocrinology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, ChinaDepartment of Endocrinology and Metabolism, Clinical Research Center, Shandong Provincial Key Medical and Health Discipline of Endocrinology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, ChinaDepartment of Endocrinology and Metabolism, Clinical Research Center, Shandong Provincial Key Medical and Health Discipline of Endocrinology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, ChinaDepartment of Endocrinology and Metabolism, Clinical Research Center, Shandong Provincial Key Medical and Health Discipline of Endocrinology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, ChinaDepartment of Pathology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, ChinaDepartment of Endocrinology and Metabolism, Clinical Research Center, Shandong Provincial Key Medical and Health Discipline of Endocrinology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, China; Corresponding author.Department of Endocrinology and Metabolism, Clinical Research Center, Shandong Provincial Key Medical and Health Discipline of Endocrinology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong 261031, China; Corresponding author.The expression and function of the receptor are controlled by epigenetic changes, such as DNA methylation, histone modification, and noncoding RNAs. These modifications play a pivotal role in receptor activity and can lead to or exacerbate endocrine-related diseases. This review examines the epigenetic alterations of nuclear receptors and their significant impact on conditions such as diabetes, thyroid disorders, and endocrine-related tumors. It highlights current therapies targeting these epigenetic mechanisms, including gene editing, epigenetic drugs, and various other therapeutic approaches. This review offers fresh insight into the mechanisms of endocrine-associated disorders, highlighting the latest progress in the development of novel epigenetic therapies that can be used to address receptor–endocrine interactions.http://www.sciencedirect.com/science/article/pii/S2352304224002782Androgen receptorBreast cancerDNA methylationEpigenetic modulationEstrogen receptorHistone modification |
| spellingShingle | Yixin Song Kexin Zhang Jingwen Zhang Qinying Li Na Huang Yujie Ma Ningning Hou Fang Han Chengxia Kan Xiaodong Sun Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies Genes and Diseases Androgen receptor Breast cancer DNA methylation Epigenetic modulation Estrogen receptor Histone modification |
| title | Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies |
| title_full | Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies |
| title_fullStr | Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies |
| title_full_unstemmed | Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies |
| title_short | Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies |
| title_sort | epigenetic regulation of nuclear receptors implications for endocrine related diseases and therapeutic strategies |
| topic | Androgen receptor Breast cancer DNA methylation Epigenetic modulation Estrogen receptor Histone modification |
| url | http://www.sciencedirect.com/science/article/pii/S2352304224002782 |
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