Case Report: Unveiling the hidden: a rare case of endometrial tuberculosis presenting as peritoneal carcinomatosis
BackgroundEndometrial tuberculosis (TB) is a rare form of extrapulmonary TB, particularly uncommon in postmenopausal women. Its atypical presentation, characterized by nonspecific symptoms, often leads to misdiagnosis, particularly when it is confused with malignancies. Moreover, peritoneal tubercul...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1607025/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849245608105213952 |
|---|---|
| author | Mariem Garci Mariem Garci Mehdi Makni Mehdi Makni Ghada Abdelmoula Ghada Abdelmoula Amani Abdeljabbar Amani Abdeljabbar Wafa Babay Nahla Ben Saada Nahla Ben Saada Fatma Dhieb Fatma Dhieb Linda Hadj Kacem Linda Hadj Kacem Nabil Mathlouthi Nabil Mathlouthi Cyrine Belghith Cyrine Belghith Olfa Slimani Olfa Slimani |
| author_facet | Mariem Garci Mariem Garci Mehdi Makni Mehdi Makni Ghada Abdelmoula Ghada Abdelmoula Amani Abdeljabbar Amani Abdeljabbar Wafa Babay Nahla Ben Saada Nahla Ben Saada Fatma Dhieb Fatma Dhieb Linda Hadj Kacem Linda Hadj Kacem Nabil Mathlouthi Nabil Mathlouthi Cyrine Belghith Cyrine Belghith Olfa Slimani Olfa Slimani |
| author_sort | Mariem Garci |
| collection | DOAJ |
| description | BackgroundEndometrial tuberculosis (TB) is a rare form of extrapulmonary TB, particularly uncommon in postmenopausal women. Its atypical presentation, characterized by nonspecific symptoms, often leads to misdiagnosis, particularly when it is confused with malignancies. Moreover, peritoneal tuberculosis, although rare, can further complicate the diagnostic process due to its clinical manifestations that resemble those of various cancerous conditions. The coexistence of both endometrial and peritoneal TB in the same patient is particularly unusual and presents a significant diagnostic challenge.Case presentationWe report the case of a 49-year-old perimenopausal woman who presented with chronic pelvic pain, ascites, and postmenopausal bleeding. Initial imaging raised suspicion for peritoneal carcinomatosis. However, histopathological and microbiological investigations confirmed the diagnosis of endometrial and peritoneal tuberculosis. The diagnosis was established by the detection of acid-fast bacilli and granulomas in the biopsies from the endometrium and peritoneum. The patient was successfully treated with a standard anti-TB regimen, showing a favorable clinical response and gradual resolution of symptoms.ConclusionThis case underscores the importance of considering tuberculosis in the differential diagnosis of pelvic pathologies, particularly in endemic regions where TB is prevalent. It highlights the need for thorough investigation in cases of atypical pelvic symptoms in patients with risk factors, even in the absence of clear pulmonary symptoms. Including tuberculosis in the differential diagnosis could prevent misdiagnosis and allow for more prompt and appropriate management. |
| format | Article |
| id | doaj-art-5b75260caab045c4bc57cd8e8f42e103 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-5b75260caab045c4bc57cd8e8f42e1032025-08-20T03:58:45ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-07-011510.3389/fonc.2025.16070251607025Case Report: Unveiling the hidden: a rare case of endometrial tuberculosis presenting as peritoneal carcinomatosisMariem Garci0Mariem Garci1Mehdi Makni2Mehdi Makni3Ghada Abdelmoula4Ghada Abdelmoula5Amani Abdeljabbar6Amani Abdeljabbar7Wafa Babay8Nahla Ben Saada9Nahla Ben Saada10Fatma Dhieb11Fatma Dhieb12Linda Hadj Kacem13Linda Hadj Kacem14Nabil Mathlouthi15Nabil Mathlouthi16Cyrine Belghith17Cyrine Belghith18Olfa Slimani19Olfa Slimani20Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, TunisiaDepartment A of Gynecology and Obstetrics, Charles Nicolle University Hospital of Tunis, Tunis, TunisiaFaculty of Medicine of Tunis, University of Tunis El Manar, Tunis, TunisiaDepartment A of Gynecology and Obstetrics, Charles Nicolle University Hospital of Tunis, Tunis, TunisiaDepartment A of Gynecology and Obstetrics, Charles Nicolle University Hospital of Tunis, Tunis, TunisiaFaculty of Medicine of Sousse, University of Sousse, Sousse, TunisiaFaculty of Medicine of Tunis, University of Tunis El Manar, Tunis, TunisiaDepartment A of Gynecology and Obstetrics, Charles Nicolle University Hospital of Tunis, Tunis, TunisiaLaboratory of microorganisms and actives biomolecules, Faculty of sciences, University of Tunis El Manar, Tunis, TunisiaFaculty of Medicine of Tunis, University of Tunis El Manar, Tunis, TunisiaDepartment A of Gynecology and Obstetrics, Charles Nicolle University Hospital of Tunis, Tunis, TunisiaFaculty of Medicine of Tunis, University of Tunis El Manar, Tunis, TunisiaDepartment of Radiology, Charles Nicolle University hospital, Tunis, TunisiaFaculty of Medicine of Tunis, University of Tunis El Manar, Tunis, TunisiaDepartment of Anatomic Pathology, Charles Nicolle Hospital, Tunis, TunisiaFaculty of Medicine of Tunis, University of Tunis El Manar, Tunis, TunisiaDepartment A of Gynecology and Obstetrics, Charles Nicolle University Hospital of Tunis, Tunis, TunisiaFaculty of Medicine of Tunis, University of Tunis El Manar, Tunis, TunisiaDepartment A of Gynecology and Obstetrics, Charles Nicolle University Hospital of Tunis, Tunis, TunisiaFaculty of Medicine of Tunis, University of Tunis El Manar, Tunis, TunisiaDepartment A of Gynecology and Obstetrics, Charles Nicolle University Hospital of Tunis, Tunis, TunisiaBackgroundEndometrial tuberculosis (TB) is a rare form of extrapulmonary TB, particularly uncommon in postmenopausal women. Its atypical presentation, characterized by nonspecific symptoms, often leads to misdiagnosis, particularly when it is confused with malignancies. Moreover, peritoneal tuberculosis, although rare, can further complicate the diagnostic process due to its clinical manifestations that resemble those of various cancerous conditions. The coexistence of both endometrial and peritoneal TB in the same patient is particularly unusual and presents a significant diagnostic challenge.Case presentationWe report the case of a 49-year-old perimenopausal woman who presented with chronic pelvic pain, ascites, and postmenopausal bleeding. Initial imaging raised suspicion for peritoneal carcinomatosis. However, histopathological and microbiological investigations confirmed the diagnosis of endometrial and peritoneal tuberculosis. The diagnosis was established by the detection of acid-fast bacilli and granulomas in the biopsies from the endometrium and peritoneum. The patient was successfully treated with a standard anti-TB regimen, showing a favorable clinical response and gradual resolution of symptoms.ConclusionThis case underscores the importance of considering tuberculosis in the differential diagnosis of pelvic pathologies, particularly in endemic regions where TB is prevalent. It highlights the need for thorough investigation in cases of atypical pelvic symptoms in patients with risk factors, even in the absence of clear pulmonary symptoms. Including tuberculosis in the differential diagnosis could prevent misdiagnosis and allow for more prompt and appropriate management.https://www.frontiersin.org/articles/10.3389/fonc.2025.1607025/fullendometrial tuberculosisperitoneal tuberculosisextrapulmonary tuberculosisperimenopausecase report |
| spellingShingle | Mariem Garci Mariem Garci Mehdi Makni Mehdi Makni Ghada Abdelmoula Ghada Abdelmoula Amani Abdeljabbar Amani Abdeljabbar Wafa Babay Nahla Ben Saada Nahla Ben Saada Fatma Dhieb Fatma Dhieb Linda Hadj Kacem Linda Hadj Kacem Nabil Mathlouthi Nabil Mathlouthi Cyrine Belghith Cyrine Belghith Olfa Slimani Olfa Slimani Case Report: Unveiling the hidden: a rare case of endometrial tuberculosis presenting as peritoneal carcinomatosis Frontiers in Oncology endometrial tuberculosis peritoneal tuberculosis extrapulmonary tuberculosis perimenopause case report |
| title | Case Report: Unveiling the hidden: a rare case of endometrial tuberculosis presenting as peritoneal carcinomatosis |
| title_full | Case Report: Unveiling the hidden: a rare case of endometrial tuberculosis presenting as peritoneal carcinomatosis |
| title_fullStr | Case Report: Unveiling the hidden: a rare case of endometrial tuberculosis presenting as peritoneal carcinomatosis |
| title_full_unstemmed | Case Report: Unveiling the hidden: a rare case of endometrial tuberculosis presenting as peritoneal carcinomatosis |
| title_short | Case Report: Unveiling the hidden: a rare case of endometrial tuberculosis presenting as peritoneal carcinomatosis |
| title_sort | case report unveiling the hidden a rare case of endometrial tuberculosis presenting as peritoneal carcinomatosis |
| topic | endometrial tuberculosis peritoneal tuberculosis extrapulmonary tuberculosis perimenopause case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1607025/full |
| work_keys_str_mv | AT mariemgarci casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT mariemgarci casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT mehdimakni casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT mehdimakni casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT ghadaabdelmoula casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT ghadaabdelmoula casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT amaniabdeljabbar casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT amaniabdeljabbar casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT wafababay casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT nahlabensaada casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT nahlabensaada casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT fatmadhieb casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT fatmadhieb casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT lindahadjkacem casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT lindahadjkacem casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT nabilmathlouthi casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT nabilmathlouthi casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT cyrinebelghith casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT cyrinebelghith casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT olfaslimani casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis AT olfaslimani casereportunveilingthehiddenararecaseofendometrialtuberculosispresentingasperitonealcarcinomatosis |