Antiviral therapy for influenza in high-risk outpatients: a multicenter observational study of routine clinical practice in Russia
Background: Influenza is a significant public health challenge, characterized by severe disease progression and considerable societal burden. Patients at high risk of influenza-related complications require special attention in routine clinical practice. Objectives: This study aimed to compare the e...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-06-01
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| Series: | Therapeutic Advances in Infectious Disease |
| Online Access: | https://doi.org/10.1177/20499361251347726 |
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| author | Ivan Tokin Dmitry Lioznov Artem Poromov Tatyana Zubkova Valerii Tsvetkov Olesya Nikitina Olga Pobegalova Natalia Pshenichnaya Viktor Renev Anastasiya Podgornaya |
| author_facet | Ivan Tokin Dmitry Lioznov Artem Poromov Tatyana Zubkova Valerii Tsvetkov Olesya Nikitina Olga Pobegalova Natalia Pshenichnaya Viktor Renev Anastasiya Podgornaya |
| author_sort | Ivan Tokin |
| collection | DOAJ |
| description | Background: Influenza is a significant public health challenge, characterized by severe disease progression and considerable societal burden. Patients at high risk of influenza-related complications require special attention in routine clinical practice. Objectives: This study aimed to compare the effects of antiviral treatments for influenza on the incidence of bacterial complications, adverse events, and disease duration in high-risk outpatients. Design: Multicenter, non-interventional, observational cohort study. Methods: The study was conducted during the 2023–2024 influenza epidemic season and included 1867 high-risk outpatients treated with oseltamivir, umifenovir, kagocel, or imidazolyl ethanamide pentanedioic acid. Results: Bacterial complications occurred in 18.87% ( n = 335) of high-risk patients, with 17.41% ( n = 309) requiring antibacterial therapy. The hospitalization rate was 1.24% ( n = 22), and the average disease duration was 8 days. The incidence of bacterial complications varied among treatment groups: oseltamivir (18.96%, n = 102), umifenovir (12.17%%, n = 51), kagocel (22.00%%, n = 110), and imidazolyl ethanamide pentanedioic acid (22.64%%, n = 72). Adverse events were reported in 4.76% ( n = 84) of patients, most commonly gastrointestinal disorders (91.67%, n = 77), followed by allergic reactions (8.33%, n = 7). The incidence of adverse events was significantly higher in the oseltamivir group compared to other treatments. Conclusion: The etiotropic agents oseltamivir and umifenovir demonstrated comparable efficacy in managing influenza in high-risk patients, as reflected by their impact on bacterial complication rates and disease duration. Both drugs may be recommended for the treatment of high-risk influenza patients. |
| format | Article |
| id | doaj-art-5b72a4a6a0de44d6801e2bd30685dc8b |
| institution | OA Journals |
| issn | 2049-937X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Infectious Disease |
| spelling | doaj-art-5b72a4a6a0de44d6801e2bd30685dc8b2025-08-20T02:10:20ZengSAGE PublishingTherapeutic Advances in Infectious Disease2049-937X2025-06-011210.1177/20499361251347726Antiviral therapy for influenza in high-risk outpatients: a multicenter observational study of routine clinical practice in RussiaIvan TokinDmitry LioznovArtem PoromovTatyana ZubkovaValerii TsvetkovOlesya NikitinaOlga PobegalovaNatalia PshenichnayaViktor RenevAnastasiya PodgornayaBackground: Influenza is a significant public health challenge, characterized by severe disease progression and considerable societal burden. Patients at high risk of influenza-related complications require special attention in routine clinical practice. Objectives: This study aimed to compare the effects of antiviral treatments for influenza on the incidence of bacterial complications, adverse events, and disease duration in high-risk outpatients. Design: Multicenter, non-interventional, observational cohort study. Methods: The study was conducted during the 2023–2024 influenza epidemic season and included 1867 high-risk outpatients treated with oseltamivir, umifenovir, kagocel, or imidazolyl ethanamide pentanedioic acid. Results: Bacterial complications occurred in 18.87% ( n = 335) of high-risk patients, with 17.41% ( n = 309) requiring antibacterial therapy. The hospitalization rate was 1.24% ( n = 22), and the average disease duration was 8 days. The incidence of bacterial complications varied among treatment groups: oseltamivir (18.96%, n = 102), umifenovir (12.17%%, n = 51), kagocel (22.00%%, n = 110), and imidazolyl ethanamide pentanedioic acid (22.64%%, n = 72). Adverse events were reported in 4.76% ( n = 84) of patients, most commonly gastrointestinal disorders (91.67%, n = 77), followed by allergic reactions (8.33%, n = 7). The incidence of adverse events was significantly higher in the oseltamivir group compared to other treatments. Conclusion: The etiotropic agents oseltamivir and umifenovir demonstrated comparable efficacy in managing influenza in high-risk patients, as reflected by their impact on bacterial complication rates and disease duration. Both drugs may be recommended for the treatment of high-risk influenza patients.https://doi.org/10.1177/20499361251347726 |
| spellingShingle | Ivan Tokin Dmitry Lioznov Artem Poromov Tatyana Zubkova Valerii Tsvetkov Olesya Nikitina Olga Pobegalova Natalia Pshenichnaya Viktor Renev Anastasiya Podgornaya Antiviral therapy for influenza in high-risk outpatients: a multicenter observational study of routine clinical practice in Russia Therapeutic Advances in Infectious Disease |
| title | Antiviral therapy for influenza in high-risk outpatients: a multicenter observational study of routine clinical practice in Russia |
| title_full | Antiviral therapy for influenza in high-risk outpatients: a multicenter observational study of routine clinical practice in Russia |
| title_fullStr | Antiviral therapy for influenza in high-risk outpatients: a multicenter observational study of routine clinical practice in Russia |
| title_full_unstemmed | Antiviral therapy for influenza in high-risk outpatients: a multicenter observational study of routine clinical practice in Russia |
| title_short | Antiviral therapy for influenza in high-risk outpatients: a multicenter observational study of routine clinical practice in Russia |
| title_sort | antiviral therapy for influenza in high risk outpatients a multicenter observational study of routine clinical practice in russia |
| url | https://doi.org/10.1177/20499361251347726 |
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