Autonomic thermoregulatory dysfunction in neurofibromatosis type 1
ABSTRACT Objective Neurofibromatosis type 1 (NF1) causes neural and cutaneous disorders and reduced exercise capacity. Exercise/heat exposure increasing internal temperature must be compensated by eccrine sweat function and warmed skin vasodilation. We suspected NF1 could adversely affect eccrine...
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| Series: | Arquivos de Neuro-Psiquiatria |
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| author | Luciana G Madeira Renata LF Passos Juliana F de Souza Nilton A Rezende Luiz O. C. Rodrigues |
| author_facet | Luciana G Madeira Renata LF Passos Juliana F de Souza Nilton A Rezende Luiz O. C. Rodrigues |
| author_sort | Luciana G Madeira |
| collection | DOAJ |
| description | ABSTRACT Objective Neurofibromatosis type 1 (NF1) causes neural and cutaneous disorders and reduced exercise capacity. Exercise/heat exposure increasing internal temperature must be compensated by eccrine sweat function and warmed skin vasodilation. We suspected NF1 could adversely affect eccrine sweat function and/or vascular thermoregulatory responses (VTR). Methods The eccrine sweat function and VTR of 25 NF1 volunteers (14 males, 11 females; 16–57 years old) were compared with 23 non-NF1 controls matched by sex, age, height and weight (CG). Sweating was induced by 1) pilocarpine 1% iontophoresis (PILO); and 2) by passive heating (HEAT) via the lower third of the legs being immersed in 42°C water for one hour. Previously established eccrine sweat function and VTR protocols were used. Results The NF1 group showed: a) lower sweat rate than the CG group during PILO; b) a smaller diastolic pressure decrease; and c) higher tympanic temperatures than controls during HEAT (p < 0.05). Conclusion Reduced sweating and vascular thermoregulatory responses suggest autonomic dysfunction in NF1 individuals. |
| format | Article |
| id | doaj-art-5b6fd0c8ef5449af85576b515bd0300e |
| institution | Kabale University |
| issn | 1678-4227 |
| language | English |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-5b6fd0c8ef5449af85576b515bd0300e2025-08-20T03:26:30ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-4227741079680210.1590/0004-282X20160122S0004-282X2016001000796Autonomic thermoregulatory dysfunction in neurofibromatosis type 1Luciana G MadeiraRenata LF PassosJuliana F de SouzaNilton A RezendeLuiz O. C. RodriguesABSTRACT Objective Neurofibromatosis type 1 (NF1) causes neural and cutaneous disorders and reduced exercise capacity. Exercise/heat exposure increasing internal temperature must be compensated by eccrine sweat function and warmed skin vasodilation. We suspected NF1 could adversely affect eccrine sweat function and/or vascular thermoregulatory responses (VTR). Methods The eccrine sweat function and VTR of 25 NF1 volunteers (14 males, 11 females; 16–57 years old) were compared with 23 non-NF1 controls matched by sex, age, height and weight (CG). Sweating was induced by 1) pilocarpine 1% iontophoresis (PILO); and 2) by passive heating (HEAT) via the lower third of the legs being immersed in 42°C water for one hour. Previously established eccrine sweat function and VTR protocols were used. Results The NF1 group showed: a) lower sweat rate than the CG group during PILO; b) a smaller diastolic pressure decrease; and c) higher tympanic temperatures than controls during HEAT (p < 0.05). Conclusion Reduced sweating and vascular thermoregulatory responses suggest autonomic dysfunction in NF1 individuals.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001000796&lng=en&tlng=enneurofibromatosis 1sweatingprimary dysautonomiasbody temperature regulation |
| spellingShingle | Luciana G Madeira Renata LF Passos Juliana F de Souza Nilton A Rezende Luiz O. C. Rodrigues Autonomic thermoregulatory dysfunction in neurofibromatosis type 1 Arquivos de Neuro-Psiquiatria neurofibromatosis 1 sweating primary dysautonomias body temperature regulation |
| title | Autonomic thermoregulatory dysfunction in neurofibromatosis type 1 |
| title_full | Autonomic thermoregulatory dysfunction in neurofibromatosis type 1 |
| title_fullStr | Autonomic thermoregulatory dysfunction in neurofibromatosis type 1 |
| title_full_unstemmed | Autonomic thermoregulatory dysfunction in neurofibromatosis type 1 |
| title_short | Autonomic thermoregulatory dysfunction in neurofibromatosis type 1 |
| title_sort | autonomic thermoregulatory dysfunction in neurofibromatosis type 1 |
| topic | neurofibromatosis 1 sweating primary dysautonomias body temperature regulation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001000796&lng=en&tlng=en |
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