Motor Dysfunction Correlates with Frontal White Matter Ischemic Changes in Patients with Leukoaraiosis
Objectives. To test the relation between white matter lesions (WML) location and physical performance, in aged patients. Methods. Subjects: 29 patients (17 males), aged >65 (mean age 72.6±5.2), with leukoaraiosis. WML was quantified with a visual scale; Apparent Diffusion Coefficient (ADC) was me...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/950341 |
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| author | Miguel Viana-Baptista Paulo Bugalho Constança Jordão Olga Ribeiro José António Esperança-Pina José Ferro |
| author_facet | Miguel Viana-Baptista Paulo Bugalho Constança Jordão Olga Ribeiro José António Esperança-Pina José Ferro |
| author_sort | Miguel Viana-Baptista |
| collection | DOAJ |
| description | Objectives. To test the relation between white matter lesions (WML) location and physical performance, in aged patients. Methods. Subjects: 29 patients (17 males), aged >65 (mean age 72.6±5.2), with leukoaraiosis. WML was quantified with a visual scale; Apparent Diffusion Coefficient (ADC) was measured bilaterally in frontal periventricular lesioned white matter and frontal and parieto-occipital normal appearing white matter (NAWM). Motor performance was studied using the Short Physical Performance Battery (SPPB), single leg stand time, finger tapping and grooved pegboard tests (GPT). Results. There were significant correlations between the frontal region visual scale scores and SPPB chair stands (r=-0.379; P=.039) and Grooved Pegboard (r=0.393; P=.032); frontal NAWM ADC values and SPPB standing balance (r=-0.450; P=.014) and SPPB 4 meter walk (r=-0.379; P=.043). Conclusion. Frontal WML are negatively related to motor performance in patients with leukoaraiosis. DWI results suggest that this may be true even for NAWM. |
| format | Article |
| id | doaj-art-5b6aed305c7c4152bfc91e33310781bf |
| institution | Kabale University |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-5b6aed305c7c4152bfc91e33310781bf2025-02-03T05:58:33ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/950341950341Motor Dysfunction Correlates with Frontal White Matter Ischemic Changes in Patients with LeukoaraiosisMiguel Viana-Baptista0Paulo Bugalho1Constança Jordão2Olga Ribeiro3José António Esperança-Pina4José Ferro5Neurology Department, Hospital de Egas Moniz (CHLO), 1349-019 Lisbon, PortugalNeurology Department, Hospital de Egas Moniz (CHLO), 1349-019 Lisbon, PortugalRessonância Magnética de Caselas, 1400-045 Lisbon, PortugalNeuropsychology Department, Hospital de Egas Moniz (CHLO), 1349-019 Lisbon, PortugalDepartment of Anatomy, Faculty of Medical Sciences, New University of Lisbon, 1200-249 Libson, PortugalNeurology Department, Faculty of Medicine, Hospital de Santa Maria, 1649-035 Lisbon, PortugalObjectives. To test the relation between white matter lesions (WML) location and physical performance, in aged patients. Methods. Subjects: 29 patients (17 males), aged >65 (mean age 72.6±5.2), with leukoaraiosis. WML was quantified with a visual scale; Apparent Diffusion Coefficient (ADC) was measured bilaterally in frontal periventricular lesioned white matter and frontal and parieto-occipital normal appearing white matter (NAWM). Motor performance was studied using the Short Physical Performance Battery (SPPB), single leg stand time, finger tapping and grooved pegboard tests (GPT). Results. There were significant correlations between the frontal region visual scale scores and SPPB chair stands (r=-0.379; P=.039) and Grooved Pegboard (r=0.393; P=.032); frontal NAWM ADC values and SPPB standing balance (r=-0.450; P=.014) and SPPB 4 meter walk (r=-0.379; P=.043). Conclusion. Frontal WML are negatively related to motor performance in patients with leukoaraiosis. DWI results suggest that this may be true even for NAWM.http://dx.doi.org/10.4061/2011/950341 |
| spellingShingle | Miguel Viana-Baptista Paulo Bugalho Constança Jordão Olga Ribeiro José António Esperança-Pina José Ferro Motor Dysfunction Correlates with Frontal White Matter Ischemic Changes in Patients with Leukoaraiosis Journal of Aging Research |
| title | Motor Dysfunction Correlates with Frontal White Matter Ischemic Changes in Patients with Leukoaraiosis |
| title_full | Motor Dysfunction Correlates with Frontal White Matter Ischemic Changes in Patients with Leukoaraiosis |
| title_fullStr | Motor Dysfunction Correlates with Frontal White Matter Ischemic Changes in Patients with Leukoaraiosis |
| title_full_unstemmed | Motor Dysfunction Correlates with Frontal White Matter Ischemic Changes in Patients with Leukoaraiosis |
| title_short | Motor Dysfunction Correlates with Frontal White Matter Ischemic Changes in Patients with Leukoaraiosis |
| title_sort | motor dysfunction correlates with frontal white matter ischemic changes in patients with leukoaraiosis |
| url | http://dx.doi.org/10.4061/2011/950341 |
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