Discovery of Novel CRK12 Inhibitors for the Treatment of Human African Trypanosomiasis: An Integrated Computational and Experimental Approach

Discovery of Novel CRK12 Inhibitors for the Treatment of Human African Trypanosomiasis: An Integrated Computational and Experimental Approach

<b>Background:</b> Human African trypanosomiasis (HAT), caused by <i>Trypanosoma brucei</i>, is a neglected tropical disease with limited treatments, highlighting the pressing need for new drugs. Cell division cycle-2-related kinase 12 (CRK12), a pivotal protein involved in t...

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Bibliographic Details
Main Authors: Qin Li, Jiayi Luo, Chenggong Fu, Wenqingqing Kang, Lingling Wang, Henry Tong, Zhaorong Lun, Qianqian Zhang, Dehua Lai, Huanxiang Liu
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
CRK12
human African trypanosomiasis (HAT)
molecular docking
virtual screening
neglected tropical disease
drug discovery
Online Access:https://www.mdpi.com/1424-8247/18/6/778
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