A rare case of resection of a mucinous cystic neoplasm originating from the extrahepatic bile duct with cholangioscopic imaging
Abstract A 29‐year‐old woman was admitted to our hospital for examination of obstructive jaundice and an extrahepatic bile duct lesion. Contrast‐enhanced computed tomography revealed a 20 mm cystic lesion with a thin external capsule in the common hepatic duct. Cholangioscopy revealed translucent ov...
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2024-04-01
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| Online Access: | https://doi.org/10.1002/deo2.349 |
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| author | Yoshiharu Masaki Yujiro Kawakami Keisuke Ishigami Ayako Murota Masahiro Shitani Kazuharu Kukita Yasutoshi Kimura Keiko Segawa Tadashi Hasegawa Hiroshi Nakase |
| author_facet | Yoshiharu Masaki Yujiro Kawakami Keisuke Ishigami Ayako Murota Masahiro Shitani Kazuharu Kukita Yasutoshi Kimura Keiko Segawa Tadashi Hasegawa Hiroshi Nakase |
| author_sort | Yoshiharu Masaki |
| collection | DOAJ |
| description | Abstract A 29‐year‐old woman was admitted to our hospital for examination of obstructive jaundice and an extrahepatic bile duct lesion. Contrast‐enhanced computed tomography revealed a 20 mm cystic lesion with a thin external capsule in the common hepatic duct. Cholangioscopy revealed translucent oval masses with capillary vessels attached to the bile duct walls. The surface was mostly smooth yet partially irregular with redness, suggesting that the masses were epithelial neoplasms. Histological findings of cholangioscopy‐guided targeted biopsies of the mass showed subepithelial spindle cell proliferation with no atypical epithelium. The patient underwent an extrahepatic bile duct resection to confirm the pathological diagnosis. Immunohistochemistry of surgical specimens revealed that the spindle cells were positive for estrogen and progesterone receptors. Finally, the cystic lesion with ovarian‐like stroma was diagnosed as a mucinous cystic neoplasm with low‐grade intraepithelial neoplasia. This is the first report of cholangioscopic imaging of a biliary mucinous cyctic neoplasm. Cholangioscopic imaging can be helpful in the differential diagnosis of biliary neoplasms and in the determination of treatment strategies. |
| format | Article |
| id | doaj-art-5b66e79482d64f648f06916582ffb436 |
| institution | Kabale University |
| issn | 2692-4609 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | DEN Open |
| spelling | doaj-art-5b66e79482d64f648f06916582ffb4362025-08-20T03:41:00ZengWileyDEN Open2692-46092024-04-0141n/an/a10.1002/deo2.349A rare case of resection of a mucinous cystic neoplasm originating from the extrahepatic bile duct with cholangioscopic imagingYoshiharu Masaki0Yujiro Kawakami1Keisuke Ishigami2Ayako Murota3Masahiro Shitani4Kazuharu Kukita5Yasutoshi Kimura6Keiko Segawa7Tadashi Hasegawa8Hiroshi Nakase9Department of Gastroenterology and Hepatology Sapporo Medical University School of Medicine Hokkaido JapanDepartment of Gastroenterology and Hepatology Sapporo Medical University School of Medicine Hokkaido JapanDepartment of Gastroenterology and Hepatology Sapporo Medical University School of Medicine Hokkaido JapanDepartment of Gastroenterology and Hepatology Sapporo Medical University School of Medicine Hokkaido JapanDepartment of Gastroenterology and Hepatology JR Sapporo Hospital Hokkaido JapanDepartment of Surgery Surgical Oncology and Science Sapporo Medical University School of Medicine Hokkaido JapanDepartment of Surgery Surgical Oncology and Science Sapporo Medical University School of Medicine Hokkaido JapanDepartment of Surgical Pathology Sapporo Medical University School of Medicine Hokkaido JapanDepartment of Surgical Pathology Sapporo Medical University School of Medicine Hokkaido JapanDepartment of Gastroenterology and Hepatology Sapporo Medical University School of Medicine Hokkaido JapanAbstract A 29‐year‐old woman was admitted to our hospital for examination of obstructive jaundice and an extrahepatic bile duct lesion. Contrast‐enhanced computed tomography revealed a 20 mm cystic lesion with a thin external capsule in the common hepatic duct. Cholangioscopy revealed translucent oval masses with capillary vessels attached to the bile duct walls. The surface was mostly smooth yet partially irregular with redness, suggesting that the masses were epithelial neoplasms. Histological findings of cholangioscopy‐guided targeted biopsies of the mass showed subepithelial spindle cell proliferation with no atypical epithelium. The patient underwent an extrahepatic bile duct resection to confirm the pathological diagnosis. Immunohistochemistry of surgical specimens revealed that the spindle cells were positive for estrogen and progesterone receptors. Finally, the cystic lesion with ovarian‐like stroma was diagnosed as a mucinous cystic neoplasm with low‐grade intraepithelial neoplasia. This is the first report of cholangioscopic imaging of a biliary mucinous cyctic neoplasm. Cholangioscopic imaging can be helpful in the differential diagnosis of biliary neoplasms and in the determination of treatment strategies.https://doi.org/10.1002/deo2.349biliary cystadenomacholangioscopic imagingextrahepatic bile ductmucinous cystic neoplasmobstructive jaundice |
| spellingShingle | Yoshiharu Masaki Yujiro Kawakami Keisuke Ishigami Ayako Murota Masahiro Shitani Kazuharu Kukita Yasutoshi Kimura Keiko Segawa Tadashi Hasegawa Hiroshi Nakase A rare case of resection of a mucinous cystic neoplasm originating from the extrahepatic bile duct with cholangioscopic imaging DEN Open biliary cystadenoma cholangioscopic imaging extrahepatic bile duct mucinous cystic neoplasm obstructive jaundice |
| title | A rare case of resection of a mucinous cystic neoplasm originating from the extrahepatic bile duct with cholangioscopic imaging |
| title_full | A rare case of resection of a mucinous cystic neoplasm originating from the extrahepatic bile duct with cholangioscopic imaging |
| title_fullStr | A rare case of resection of a mucinous cystic neoplasm originating from the extrahepatic bile duct with cholangioscopic imaging |
| title_full_unstemmed | A rare case of resection of a mucinous cystic neoplasm originating from the extrahepatic bile duct with cholangioscopic imaging |
| title_short | A rare case of resection of a mucinous cystic neoplasm originating from the extrahepatic bile duct with cholangioscopic imaging |
| title_sort | rare case of resection of a mucinous cystic neoplasm originating from the extrahepatic bile duct with cholangioscopic imaging |
| topic | biliary cystadenoma cholangioscopic imaging extrahepatic bile duct mucinous cystic neoplasm obstructive jaundice |
| url | https://doi.org/10.1002/deo2.349 |
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