A 14-year retrospective study on clinical and histopathological features of epithelial salivary gland neoplasms
Objectives: To investigate and describe the clinicopathological profile of pleomorphic adenoma, salivary adenoid cystic carcinoma, and mucoepidermoid carcinoma cases at a Northeast Brazilian Oral Pathology referral center. Methods: Clinical features, histopathological diagnoses, subtypes, and speci...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Portuguesa de Estomatologia e Medicina Dentária
2025-03-01
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| Series: | Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial |
| Subjects: | |
| Online Access: | https://administracao.spemd.pt/app/assets/imagens/files_img/1_19_67ebba12e7cc8.pdf |
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| Summary: | Objectives: To investigate and describe the clinicopathological profile of pleomorphic adenoma, salivary adenoid cystic carcinoma, and mucoepidermoid carcinoma cases at a Northeast Brazilian Oral Pathology referral center.
Methods: Clinical features, histopathological diagnoses, subtypes, and specific histopathological features were collected from all cases previously diagnosed as pleomorphic adenoma,
adenoid cystic carcinoma, or mucoepidermoid carcinoma between 2008 and 2021.
Results: Among 9613 cases diagnosed at the service, 86 (0.75%) were salivary gland neoplasms, included in this study. Of these, pleomorphic adenomas were the most common
neoplasm (n = 49; 57.0%), followed by mucoepidermoid carcinomas (n = 23; 26.7%) and adenoid cystic carcinomas (n = 14; 16.3%). Patients ranged in age from 8 to 87 years old (mean
age, 44.5 years), and the majority were female (65.3%). The palate was the most affected site
in all salivary gland neoplasms. The predominant classifications were classical subtypes in
pleomorphic adenomas (65.3%), cribriform and solid patterns in adenoid cystic carcinomas
(42.8% both), and low-grade in mucoepidermoid carcinomas (n = 10; 43.5%). Adenoid cystic
carcinoma cases were associated with pain (p < 0.001), age > 45 years (p = 0.024), and evolution time < 12 months (p = 0.019).
Conclusions: The findings of this study align with the literature. Although salivary gland
neoplasms present overlapping clinical features, the association between clinical variables
and adenoid cystic carcinoma diagnosis might aid clinical practice. |
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| ISSN: | 1646-2890 1647-6700 |