A spreadable self-gelling hemostatic powder sensitizes CAR-NK cell therapy to prevent hepatocellular carcinoma recurrence postresection

A spreadable self-gelling hemostatic powder sensitizes CAR-NK cell therapy to prevent hepatocellular carcinoma recurrence postresection

Abstract Adoptive natural killer cell therapy (ANKCT) harbors great potential for combating postsurgical hepatocellular carcinoma (HCC) recurrence, but its efficacy is limited by tumor microenvironment (TME)-meditated repression on NK cell function and insufficient NK cell homing to tumor sites. The...

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Bibliographic Details
Main Authors: Yusheng Cheng, Yihang Gong, Xin Li, Fanxin Zeng, Bo Liu, Wenjie Chen, Feng Zhang, Haofei Chen, Weixiong Zhu, Hui Li, Lei Zhou, Tiangen Wu, Wence Zhou
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Nanocomposite hydrogel
Drug delivery
Hemostasis
Hepatocellular carcinoma
NK cell therapy
Online Access:https://doi.org/10.1186/s12951-025-03424-9
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