Burden of Comorbidities and Healthcare Resource Utilization Among Medicaid-Enrolled Extremely Premature Infants
**Background:** The effect of gestational age (GA) on comorbidity prevalence, healthcare resource utilization (HCRU), and all-cause costs is significant for extremely premature (EP) infants in the United States. **Objectives:** To characterize real-world patient characteristics, prevalence of comor...
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| Format: | Article |
| Language: | English |
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Columbia Data Analytics, LLC
2022-12-01
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| Series: | Journal of Health Economics and Outcomes Research |
| Online Access: | https://doi.org/10.36469/001c.38847 |
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| author | Meredith E. Mowitz Wei Gao Heather Sipsma Pete Zuckerman Hallee Wong Rajeev Ayyagari Sujata P. Sarda |
| author_facet | Meredith E. Mowitz Wei Gao Heather Sipsma Pete Zuckerman Hallee Wong Rajeev Ayyagari Sujata P. Sarda |
| author_sort | Meredith E. Mowitz |
| collection | DOAJ |
| description | **Background:** The effect of gestational age (GA) on comorbidity prevalence, healthcare resource utilization (HCRU), and all-cause costs is significant for extremely premature (EP) infants in the United States.
**Objectives:** To characterize real-world patient characteristics, prevalence of comorbidities, rates of HCRU, and direct healthcare charges and societal costs among premature infants in US Medicaid programs, with respect to GA and the presence of respiratory comorbidities.
**Methods:** Using _International Classification of Diseases, Ninth/Tenth Revision, Clinical Modification_ codes, diagnosis and medical claims data from 6 state Medicaid databases (1997-2018) of infants born at less than 37 weeks of GA (wGA) were collected retrospectively. Data from the index date (birth) up to 2 years corrected age or death, stratified by GA (EP, ≤28 wGA; very premature \[VP\], >28 to <32 wGA; and moderate to late premature \[M-LP\], ≥32 to <37 wGA), were compared using unadjusted and adjusted generalized linear models.
**Results:** Among 25 573 premature infants (46.1% female; 4462 \[17.4%\] EP; 2904 \[11.4%\] VP; 18 207 \[71.2%\] M-LP), comorbidity prevalence, HCRU, and all-cause costs increased with decreasing GA and were highest for EP. Total healthcare charges, excluding index hospitalization and all-cause societal costs (US dollars), were 2 to 3 times higher for EP than for M-LP (EP $74 436 vs M-LP $27 541 and EP $28 504 vs M-LP $15 892, respectively).
**Conclusions:** Complications of preterm birth, including prevalence of comorbidities, HCRU, and costs, increased with decreasing GA and were highest among EP infants during the first 2 years in this US analysis. |
| format | Article |
| id | doaj-art-5b6087529101443d94c8a9b86c3c2cbd |
| institution | Kabale University |
| issn | 2327-2236 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Columbia Data Analytics, LLC |
| record_format | Article |
| series | Journal of Health Economics and Outcomes Research |
| spelling | doaj-art-5b6087529101443d94c8a9b86c3c2cbd2025-02-10T16:13:33ZengColumbia Data Analytics, LLCJournal of Health Economics and Outcomes Research2327-22362022-12-0192Burden of Comorbidities and Healthcare Resource Utilization Among Medicaid-Enrolled Extremely Premature InfantsMeredith E. MowitzWei GaoHeather SipsmaPete ZuckermanHallee WongRajeev AyyagariSujata P. Sarda**Background:** The effect of gestational age (GA) on comorbidity prevalence, healthcare resource utilization (HCRU), and all-cause costs is significant for extremely premature (EP) infants in the United States. **Objectives:** To characterize real-world patient characteristics, prevalence of comorbidities, rates of HCRU, and direct healthcare charges and societal costs among premature infants in US Medicaid programs, with respect to GA and the presence of respiratory comorbidities. **Methods:** Using _International Classification of Diseases, Ninth/Tenth Revision, Clinical Modification_ codes, diagnosis and medical claims data from 6 state Medicaid databases (1997-2018) of infants born at less than 37 weeks of GA (wGA) were collected retrospectively. Data from the index date (birth) up to 2 years corrected age or death, stratified by GA (EP, ≤28 wGA; very premature \[VP\], >28 to <32 wGA; and moderate to late premature \[M-LP\], ≥32 to <37 wGA), were compared using unadjusted and adjusted generalized linear models. **Results:** Among 25 573 premature infants (46.1% female; 4462 \[17.4%\] EP; 2904 \[11.4%\] VP; 18 207 \[71.2%\] M-LP), comorbidity prevalence, HCRU, and all-cause costs increased with decreasing GA and were highest for EP. Total healthcare charges, excluding index hospitalization and all-cause societal costs (US dollars), were 2 to 3 times higher for EP than for M-LP (EP $74 436 vs M-LP $27 541 and EP $28 504 vs M-LP $15 892, respectively). **Conclusions:** Complications of preterm birth, including prevalence of comorbidities, HCRU, and costs, increased with decreasing GA and were highest among EP infants during the first 2 years in this US analysis.https://doi.org/10.36469/001c.38847 |
| spellingShingle | Meredith E. Mowitz Wei Gao Heather Sipsma Pete Zuckerman Hallee Wong Rajeev Ayyagari Sujata P. Sarda Burden of Comorbidities and Healthcare Resource Utilization Among Medicaid-Enrolled Extremely Premature Infants Journal of Health Economics and Outcomes Research |
| title | Burden of Comorbidities and Healthcare Resource Utilization Among Medicaid-Enrolled Extremely Premature Infants |
| title_full | Burden of Comorbidities and Healthcare Resource Utilization Among Medicaid-Enrolled Extremely Premature Infants |
| title_fullStr | Burden of Comorbidities and Healthcare Resource Utilization Among Medicaid-Enrolled Extremely Premature Infants |
| title_full_unstemmed | Burden of Comorbidities and Healthcare Resource Utilization Among Medicaid-Enrolled Extremely Premature Infants |
| title_short | Burden of Comorbidities and Healthcare Resource Utilization Among Medicaid-Enrolled Extremely Premature Infants |
| title_sort | burden of comorbidities and healthcare resource utilization among medicaid enrolled extremely premature infants |
| url | https://doi.org/10.36469/001c.38847 |
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