Synthesis and Characterization of Some New Morpholine Derivatives
In this paper a new series of morpholine derivatives was prepared by reacting the morpholine with ethyl chloro acetate in the presence triethylamine as a catalyst in benzene gave morpholin-N-ethyl acetate(1) which reacted with hydrazine hydrate in ethanol, and gave morpholin-N-ethyl acetohydrazid...
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University of Baghdad, College of Science for Women
2016-06-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2771 |
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| description | In this paper a new series of morpholine derivatives was prepared by reacting the morpholine with ethyl chloro acetate in the presence triethylamine as a catalyst in benzene gave morpholin-N-ethyl acetate(1) which reacted with hydrazine hydrate in ethanol, and gave morpholin-N-ethyl acetohydrazide (2) . Morpholin-N-aceto semithiocarbazide (3) were prepared by reacting compound(2) with ammonium thiocyanate , concentrated hydrochloric acid and ethanol as a solvent .Compound (3) reacted with sodium hydroxide and hydrochloric acid to give 5-(morpholin-N-methylene)-1H-1,2,4-triazole-3-thiol (4) .The new series of 1,2,4-triazol derivatives (5-8) was synthesized by reaction of compound(4) with formaldehyde , DMF as a solvent and different secondary amines. Preparation of new 1,2,4-triazoline derivatives (9) by reaction compound (4) with bromo acetic acid . Reaction of compound (9) with different aromatic aldehyde and dimethyl sulfoxide as a solvent obtained compounds (10-13). |
| format | Article |
| id | doaj-art-5b5fc83c36d248e5a2573b76948c585d |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-5b5fc83c36d248e5a2573b76948c585d2025-08-20T03:56:18ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862016-06-0113210.21123/bsj.13.2.253-265Synthesis and Characterization of Some New Morpholine DerivativesBaghdad Science JournalIn this paper a new series of morpholine derivatives was prepared by reacting the morpholine with ethyl chloro acetate in the presence triethylamine as a catalyst in benzene gave morpholin-N-ethyl acetate(1) which reacted with hydrazine hydrate in ethanol, and gave morpholin-N-ethyl acetohydrazide (2) . Morpholin-N-aceto semithiocarbazide (3) were prepared by reacting compound(2) with ammonium thiocyanate , concentrated hydrochloric acid and ethanol as a solvent .Compound (3) reacted with sodium hydroxide and hydrochloric acid to give 5-(morpholin-N-methylene)-1H-1,2,4-triazole-3-thiol (4) .The new series of 1,2,4-triazol derivatives (5-8) was synthesized by reaction of compound(4) with formaldehyde , DMF as a solvent and different secondary amines. Preparation of new 1,2,4-triazoline derivatives (9) by reaction compound (4) with bromo acetic acid . Reaction of compound (9) with different aromatic aldehyde and dimethyl sulfoxide as a solvent obtained compounds (10-13).http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2771"Morpholine , 1,2,4-triazole and Mannich Reaction" |
| spellingShingle | Baghdad Science Journal Synthesis and Characterization of Some New Morpholine Derivatives مجلة بغداد للعلوم "Morpholine , 1,2,4-triazole and Mannich Reaction" |
| title | Synthesis and Characterization of Some New Morpholine Derivatives |
| title_full | Synthesis and Characterization of Some New Morpholine Derivatives |
| title_fullStr | Synthesis and Characterization of Some New Morpholine Derivatives |
| title_full_unstemmed | Synthesis and Characterization of Some New Morpholine Derivatives |
| title_short | Synthesis and Characterization of Some New Morpholine Derivatives |
| title_sort | synthesis and characterization of some new morpholine derivatives |
| topic | "Morpholine , 1,2,4-triazole and Mannich Reaction" |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2771 |
| work_keys_str_mv | AT baghdadsciencejournal synthesisandcharacterizationofsomenewmorpholinederivatives |