The Interaction and Implication of Stress-Induced Hyperglycemia and Cytokine Release Following Traumatic Injury: A Structured Scoping Review
Introduction: This is a structured scoping review to assess whether there is a relationship between stress-induced hyperglycemia (SIH), cytokine interactions, and mortality in trauma patients in comparison to non-diabetic normoglycemia [NDN], diabetic normoglycemia [DN], and diabetic hyperglycemia [...
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MDPI AG
2024-11-01
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| author | Ibrahim Al-Hassani Naushad Ahmad Khan Eman Elmenyar Ammar Al-Hassani Sandro Rizoli Hassan Al-Thani Ayman El-Menyar |
| author_facet | Ibrahim Al-Hassani Naushad Ahmad Khan Eman Elmenyar Ammar Al-Hassani Sandro Rizoli Hassan Al-Thani Ayman El-Menyar |
| author_sort | Ibrahim Al-Hassani |
| collection | DOAJ |
| description | Introduction: This is a structured scoping review to assess whether there is a relationship between stress-induced hyperglycemia (SIH), cytokine interactions, and mortality in trauma patients in comparison to non-diabetic normoglycemia [NDN], diabetic normoglycemia [DN], and diabetic hyperglycemia [DH]. Methods: We conducted a literature search of MEDLINE (PubMed) databases from 2000 to 2022 using a search strategy to identify observational studies. Initially, 2879 articles were retrieved. Of these, 2869 were excluded due to insufficient variables, and non-trauma focuses. Results: Nine studies on the interaction between SIH and proinflammatory cytokines were analyzed. SIH was associated with the highest mortality rate (21.3%), followed by DH (5.4%), DN (2.8%), and NDN (2.3%) (<i>p</i> < 0.001). Furthermore, SIH patients exhibited an 11.28-fold higher likelihood of mortality compared to NDN patients (95% CI [9.13–13.93]; <i>p</i> < 0.001) and a 4.72-fold higher likelihood compared to DH patients (OR 4.72; 95% CI [3.55–6.27]; <i>p</i> < 0.001). Conclusions: SIH patients had elevated IL-6 concentrations relative to NDN, DN, and DH patients. SIH is linked to higher mortality in trauma, with greater odds than NDN. However, the robustness of this association is still being determined due to statistical and clinical variability. Uncertainties about injury severity and IL-6 level similarities between SIH and DH patients require further investigation. |
| format | Article |
| id | doaj-art-5b5bec0830dc41d5bcb90f804c3fabfa |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-5b5bec0830dc41d5bcb90f804c3fabfa2025-08-20T02:38:36ZengMDPI AGDiagnostics2075-44182024-11-011423264910.3390/diagnostics14232649The Interaction and Implication of Stress-Induced Hyperglycemia and Cytokine Release Following Traumatic Injury: A Structured Scoping ReviewIbrahim Al-Hassani0Naushad Ahmad Khan1Eman Elmenyar2Ammar Al-Hassani3Sandro Rizoli4Hassan Al-Thani5Ayman El-Menyar6Weill Cornell Medical College, Doha P.O. Box 24144, QatarDepartment of Surgery, Clinical Research, Trauma & Vascular Surgery, Hamad Medical Corporation, Doha P.O. Box 3050, QatarFaculty of Medicine, Bahcesehir University, Istanbul 34734, TürkiyeDepartment of Surgery, Trauma Surgery, Hamad Medical Corporation, Doha P.O. Box 3050, QatarDepartment of Surgery, Trauma Surgery, Hamad Medical Corporation, Doha P.O. Box 3050, QatarDepartment of Surgery, Trauma and Vascular Surgery, Hamad Medical Corporation, Doha P.O. Box 3050, QatarDepartment of Surgery, Clinical Research, Trauma & Vascular Surgery, Hamad Medical Corporation, Doha P.O. Box 3050, QatarIntroduction: This is a structured scoping review to assess whether there is a relationship between stress-induced hyperglycemia (SIH), cytokine interactions, and mortality in trauma patients in comparison to non-diabetic normoglycemia [NDN], diabetic normoglycemia [DN], and diabetic hyperglycemia [DH]. Methods: We conducted a literature search of MEDLINE (PubMed) databases from 2000 to 2022 using a search strategy to identify observational studies. Initially, 2879 articles were retrieved. Of these, 2869 were excluded due to insufficient variables, and non-trauma focuses. Results: Nine studies on the interaction between SIH and proinflammatory cytokines were analyzed. SIH was associated with the highest mortality rate (21.3%), followed by DH (5.4%), DN (2.8%), and NDN (2.3%) (<i>p</i> < 0.001). Furthermore, SIH patients exhibited an 11.28-fold higher likelihood of mortality compared to NDN patients (95% CI [9.13–13.93]; <i>p</i> < 0.001) and a 4.72-fold higher likelihood compared to DH patients (OR 4.72; 95% CI [3.55–6.27]; <i>p</i> < 0.001). Conclusions: SIH patients had elevated IL-6 concentrations relative to NDN, DN, and DH patients. SIH is linked to higher mortality in trauma, with greater odds than NDN. However, the robustness of this association is still being determined due to statistical and clinical variability. Uncertainties about injury severity and IL-6 level similarities between SIH and DH patients require further investigation.https://www.mdpi.com/2075-4418/14/23/2649traumahyperglycemiastress-inducedcytokinesmortalitystructured scoping review |
| spellingShingle | Ibrahim Al-Hassani Naushad Ahmad Khan Eman Elmenyar Ammar Al-Hassani Sandro Rizoli Hassan Al-Thani Ayman El-Menyar The Interaction and Implication of Stress-Induced Hyperglycemia and Cytokine Release Following Traumatic Injury: A Structured Scoping Review Diagnostics trauma hyperglycemia stress-induced cytokines mortality structured scoping review |
| title | The Interaction and Implication of Stress-Induced Hyperglycemia and Cytokine Release Following Traumatic Injury: A Structured Scoping Review |
| title_full | The Interaction and Implication of Stress-Induced Hyperglycemia and Cytokine Release Following Traumatic Injury: A Structured Scoping Review |
| title_fullStr | The Interaction and Implication of Stress-Induced Hyperglycemia and Cytokine Release Following Traumatic Injury: A Structured Scoping Review |
| title_full_unstemmed | The Interaction and Implication of Stress-Induced Hyperglycemia and Cytokine Release Following Traumatic Injury: A Structured Scoping Review |
| title_short | The Interaction and Implication of Stress-Induced Hyperglycemia and Cytokine Release Following Traumatic Injury: A Structured Scoping Review |
| title_sort | interaction and implication of stress induced hyperglycemia and cytokine release following traumatic injury a structured scoping review |
| topic | trauma hyperglycemia stress-induced cytokines mortality structured scoping review |
| url | https://www.mdpi.com/2075-4418/14/23/2649 |
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