Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury
This study aimed to investigate the potential protective properties of a traditional Chinese medicine (TCM) herbal product, Siraitia grosvenorii granules (SGG) against PM2.5-induced lung injury, as well as their active constituents and underlying mechanisms. The chemical composition of SGG, such as...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325000387 |
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| author | Qi Shao Yan Zhao YuYu Shi Fafeng Cheng ZeHan Zhang Ying Liu ChangXiang Li ZiLin Ren Hua Bai Haojie Cheng Rolando Maddela Junqiang Tian Xueqian Wang |
| author_facet | Qi Shao Yan Zhao YuYu Shi Fafeng Cheng ZeHan Zhang Ying Liu ChangXiang Li ZiLin Ren Hua Bai Haojie Cheng Rolando Maddela Junqiang Tian Xueqian Wang |
| author_sort | Qi Shao |
| collection | DOAJ |
| description | This study aimed to investigate the potential protective properties of a traditional Chinese medicine (TCM) herbal product, Siraitia grosvenorii granules (SGG) against PM2.5-induced lung injury, as well as their active constituents and underlying mechanisms. The chemical composition of SGG, such as wogonin (MOL000173), luteolin (MOL000006), nobiletin (MOL005828), naringenin (MOL004328), acacetin (MOL001689), were identified via ultra-high-performance liquid chromatography-Q Exactive (UHPLC-QE) Orbitrap/MS. The specific targets and pathways through which the compounds exert their effects on acute lung injury were then predicted via network pharmacology. The lung-protective effects of SGG against particulate matter (PM2.5) were investigated via in vivo experiments. Results showed that PM2.5-induced lung damage was associated with oxidative stress, suppression of PI3K/AKT/Nrf2 pathway, and increased levels of certain alarmins & cytokines in blood and bronchial alveolar lavage fluid (BALF). However, SGG reversed these changes, particularly tissue damage and oxidative stress, suggesting that lung protection is mediated by the antioxidant effect, which mitigates the release of alarmin and inflammation. |
| format | Article |
| id | doaj-art-5b555fea0ab84955816cdc019e12d5ee |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-5b555fea0ab84955816cdc019e12d5ee2025-02-12T05:30:04ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117702Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injuryQi Shao0Yan Zhao1YuYu Shi2Fafeng Cheng3ZeHan Zhang4Ying Liu5ChangXiang Li6ZiLin Ren7Hua Bai8Haojie Cheng9Rolando Maddela10Junqiang Tian11Xueqian Wang12College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaCollege of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaCollege of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaCollege of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaCollege of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaCollege of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaCollege of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaCollege of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaBabyCare Ltd, ChinaUSANA Health Science, Inc, USAUSANA Health Science, Inc, USAUSANA Health Science, Inc, USA; Corresponding authors.College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China; Corresponding authors.This study aimed to investigate the potential protective properties of a traditional Chinese medicine (TCM) herbal product, Siraitia grosvenorii granules (SGG) against PM2.5-induced lung injury, as well as their active constituents and underlying mechanisms. The chemical composition of SGG, such as wogonin (MOL000173), luteolin (MOL000006), nobiletin (MOL005828), naringenin (MOL004328), acacetin (MOL001689), were identified via ultra-high-performance liquid chromatography-Q Exactive (UHPLC-QE) Orbitrap/MS. The specific targets and pathways through which the compounds exert their effects on acute lung injury were then predicted via network pharmacology. The lung-protective effects of SGG against particulate matter (PM2.5) were investigated via in vivo experiments. Results showed that PM2.5-induced lung damage was associated with oxidative stress, suppression of PI3K/AKT/Nrf2 pathway, and increased levels of certain alarmins & cytokines in blood and bronchial alveolar lavage fluid (BALF). However, SGG reversed these changes, particularly tissue damage and oxidative stress, suggesting that lung protection is mediated by the antioxidant effect, which mitigates the release of alarmin and inflammation.http://www.sciencedirect.com/science/article/pii/S0147651325000387Siraitia grosvenoriiChemical characterizationNetwork pharmacologyPM2.5PI3K/AKT/Nrf2 |
| spellingShingle | Qi Shao Yan Zhao YuYu Shi Fafeng Cheng ZeHan Zhang Ying Liu ChangXiang Li ZiLin Ren Hua Bai Haojie Cheng Rolando Maddela Junqiang Tian Xueqian Wang Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury Ecotoxicology and Environmental Safety Siraitia grosvenorii Chemical characterization Network pharmacology PM2.5 PI3K/AKT/Nrf2 |
| title | Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury |
| title_full | Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury |
| title_fullStr | Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury |
| title_full_unstemmed | Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury |
| title_short | Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury |
| title_sort | chemical characterization of siraitia grosvenorii granules and their efficacy and mechanism of action on pm2 5 induced acute lung injury |
| topic | Siraitia grosvenorii Chemical characterization Network pharmacology PM2.5 PI3K/AKT/Nrf2 |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325000387 |
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