Hollow Mesoporous Carbon Nanospheres Derived from Metal–Organic Frameworks for Efficient Sono-immunotherapy against Pancreatic Cancer
Sono-immunotherapy is expected to effectively enhance treatment efficacy and reduce mortality in patients with pancreatic cancer. Hence, efficient applicable sono-immunotherapy systems are urgently needed for the treatment of this condition. In this study, hollow mesoporous carbon (HMC) nanoparticle...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2025-01-01
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| Series: | Cyborg and Bionic Systems |
| Online Access: | https://spj.science.org/doi/10.34133/cbsystems.0247 |
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| author | Libin Chen Haiwei Li Jing Liu Yunzhong Wang Shengmin Zhang |
| author_facet | Libin Chen Haiwei Li Jing Liu Yunzhong Wang Shengmin Zhang |
| author_sort | Libin Chen |
| collection | DOAJ |
| description | Sono-immunotherapy is expected to effectively enhance treatment efficacy and reduce mortality in patients with pancreatic cancer. Hence, efficient applicable sono-immunotherapy systems are urgently needed for the treatment of this condition. In this study, hollow mesoporous carbon (HMC) nanoparticles were prepared using the sacrificial template method. These nanoparticles had a porphyrin-like structure and could generate singlet oxygen more efficiently than commercial TiO2. Cellular assays showed that HMC killed tumor cells in the presence of ultrasonication, primarily by inducing apoptosis. HMC could also accelerate the release of immune factors by tumor cells, thereby activating dendritic cells and enhancing the efficacy of immunotherapy. Experiments in tumor-bearing mice and in situ pancreatic cancer tests showed that HMC, in combination with the small-molecule inhibitors of programmed cell death ligand 1, could reduce tumor growth via the generation of reactive oxygen species following ultrasonication. HMC could enhance the efficacy of immunotherapy by disrupting the immunosuppressive tumor microenvironment and promoting the accumulation of immune cells. Accordingly, in vivo sono-immunotherapy was achieved, and the growth of transplanted tumors and in situ tumors could be reduced. In conclusion, this study proposes a novel method for the preparation of HMC nanoparticles and demonstrates their potential in tumor treatment. Additionally, owing to their unique structure, these HMC nanoparticles could be used for different combination therapies tailored based on specific clinical requirements. |
| format | Article |
| id | doaj-art-5b540bd00cdb471b930e2f4f634a24c0 |
| institution | Kabale University |
| issn | 2692-7632 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Cyborg and Bionic Systems |
| spelling | doaj-art-5b540bd00cdb471b930e2f4f634a24c02025-08-20T03:53:07ZengAmerican Association for the Advancement of Science (AAAS)Cyborg and Bionic Systems2692-76322025-01-01610.34133/cbsystems.0247Hollow Mesoporous Carbon Nanospheres Derived from Metal–Organic Frameworks for Efficient Sono-immunotherapy against Pancreatic CancerLibin Chen0Haiwei Li1Jing Liu2Yunzhong Wang3Shengmin Zhang4Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Shenyang 110042, China.Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Shenyang 110042, China.Department of Radiology, The First Hospital of China Medical University, Shenyang 110001, China.Department of Ultrasound Medicine, The First Affiliated Hospital of Ningbo University, Ningbo 315010, China.Department of Ultrasound Medicine, The First Affiliated Hospital of Ningbo University, Ningbo 315010, China.Sono-immunotherapy is expected to effectively enhance treatment efficacy and reduce mortality in patients with pancreatic cancer. Hence, efficient applicable sono-immunotherapy systems are urgently needed for the treatment of this condition. In this study, hollow mesoporous carbon (HMC) nanoparticles were prepared using the sacrificial template method. These nanoparticles had a porphyrin-like structure and could generate singlet oxygen more efficiently than commercial TiO2. Cellular assays showed that HMC killed tumor cells in the presence of ultrasonication, primarily by inducing apoptosis. HMC could also accelerate the release of immune factors by tumor cells, thereby activating dendritic cells and enhancing the efficacy of immunotherapy. Experiments in tumor-bearing mice and in situ pancreatic cancer tests showed that HMC, in combination with the small-molecule inhibitors of programmed cell death ligand 1, could reduce tumor growth via the generation of reactive oxygen species following ultrasonication. HMC could enhance the efficacy of immunotherapy by disrupting the immunosuppressive tumor microenvironment and promoting the accumulation of immune cells. Accordingly, in vivo sono-immunotherapy was achieved, and the growth of transplanted tumors and in situ tumors could be reduced. In conclusion, this study proposes a novel method for the preparation of HMC nanoparticles and demonstrates their potential in tumor treatment. Additionally, owing to their unique structure, these HMC nanoparticles could be used for different combination therapies tailored based on specific clinical requirements.https://spj.science.org/doi/10.34133/cbsystems.0247 |
| spellingShingle | Libin Chen Haiwei Li Jing Liu Yunzhong Wang Shengmin Zhang Hollow Mesoporous Carbon Nanospheres Derived from Metal–Organic Frameworks for Efficient Sono-immunotherapy against Pancreatic Cancer Cyborg and Bionic Systems |
| title | Hollow Mesoporous Carbon Nanospheres Derived from Metal–Organic Frameworks for Efficient Sono-immunotherapy against Pancreatic Cancer |
| title_full | Hollow Mesoporous Carbon Nanospheres Derived from Metal–Organic Frameworks for Efficient Sono-immunotherapy against Pancreatic Cancer |
| title_fullStr | Hollow Mesoporous Carbon Nanospheres Derived from Metal–Organic Frameworks for Efficient Sono-immunotherapy against Pancreatic Cancer |
| title_full_unstemmed | Hollow Mesoporous Carbon Nanospheres Derived from Metal–Organic Frameworks for Efficient Sono-immunotherapy against Pancreatic Cancer |
| title_short | Hollow Mesoporous Carbon Nanospheres Derived from Metal–Organic Frameworks for Efficient Sono-immunotherapy against Pancreatic Cancer |
| title_sort | hollow mesoporous carbon nanospheres derived from metal organic frameworks for efficient sono immunotherapy against pancreatic cancer |
| url | https://spj.science.org/doi/10.34133/cbsystems.0247 |
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