A Case of Hemolytic Disease of the Newborn due to Dia Antibody
Anti-Dia is a clinically significant red cell antibody known to cause hemolytic disease of the newborn. Here, we report on a case of mild hemolytic disease of the newborn caused by Dia antibody. The mother had three prior pregnancies with no history of blood transfusion. She delivered a preterm 35-w...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2015/897803 |
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| author | Ashif Jethava Esperanza Olivares Sherry Shariatmadar |
| author_facet | Ashif Jethava Esperanza Olivares Sherry Shariatmadar |
| author_sort | Ashif Jethava |
| collection | DOAJ |
| description | Anti-Dia is a clinically significant red cell antibody known to cause hemolytic disease of the newborn. Here, we report on a case of mild hemolytic disease of the newborn caused by Dia antibody. The mother had three prior pregnancies with no history of blood transfusion. She delivered a preterm 35-week-old female newborn by cesarean section. The neonate developed anemia and mild icterus on postnatal day five with hemoglobin of 9500 mg/dL and total bilirubin of 10 mg/dL. The direct antiglobulin test on the neonate’s red blood cells was positive. The maternal serum and an eluate from the infant RBCs were negative in routine antibody detection tests but were positive using commercially prepared Di(a+) red cells. The neonate was discharged home in stable condition following treatment with erythropoietin and phototherapy. When a newborn has a positive DAT in the absence of major blood group incompatibility or commonly detected RBC antibodies, an antibody to a low frequency antigen such as Dia must be considered. Further immunohematology tests are required to determine presence of the antibody and the clinician must be alerted to closely monitor the infant for signs of anemia and hemolysis. |
| format | Article |
| id | doaj-art-5b504a7ab28f449cb770ff32ef885cf1 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-5b504a7ab28f449cb770ff32ef885cf12025-08-20T03:35:00ZengWileyCase Reports in Pediatrics2090-68032090-68112015-01-01201510.1155/2015/897803897803A Case of Hemolytic Disease of the Newborn due to Dia AntibodyAshif Jethava0Esperanza Olivares1Sherry Shariatmadar2Department of Pathology, University of Miami, Jackson Health System, Miami, FL, USADepartment of Pathology, University of Miami, Jackson Health System, Miami, FL, USADepartment of Pathology, University of Miami, Jackson Health System, Miami, FL, USAAnti-Dia is a clinically significant red cell antibody known to cause hemolytic disease of the newborn. Here, we report on a case of mild hemolytic disease of the newborn caused by Dia antibody. The mother had three prior pregnancies with no history of blood transfusion. She delivered a preterm 35-week-old female newborn by cesarean section. The neonate developed anemia and mild icterus on postnatal day five with hemoglobin of 9500 mg/dL and total bilirubin of 10 mg/dL. The direct antiglobulin test on the neonate’s red blood cells was positive. The maternal serum and an eluate from the infant RBCs were negative in routine antibody detection tests but were positive using commercially prepared Di(a+) red cells. The neonate was discharged home in stable condition following treatment with erythropoietin and phototherapy. When a newborn has a positive DAT in the absence of major blood group incompatibility or commonly detected RBC antibodies, an antibody to a low frequency antigen such as Dia must be considered. Further immunohematology tests are required to determine presence of the antibody and the clinician must be alerted to closely monitor the infant for signs of anemia and hemolysis.http://dx.doi.org/10.1155/2015/897803 |
| spellingShingle | Ashif Jethava Esperanza Olivares Sherry Shariatmadar A Case of Hemolytic Disease of the Newborn due to Dia Antibody Case Reports in Pediatrics |
| title | A Case of Hemolytic Disease of the Newborn due to Dia Antibody |
| title_full | A Case of Hemolytic Disease of the Newborn due to Dia Antibody |
| title_fullStr | A Case of Hemolytic Disease of the Newborn due to Dia Antibody |
| title_full_unstemmed | A Case of Hemolytic Disease of the Newborn due to Dia Antibody |
| title_short | A Case of Hemolytic Disease of the Newborn due to Dia Antibody |
| title_sort | case of hemolytic disease of the newborn due to dia antibody |
| url | http://dx.doi.org/10.1155/2015/897803 |
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