LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic pain
Healthcare providers face the challenging task of managing patients who suffer from chronic nociplastic pain conditions. Pain is a multidimensional experience, and the current approach to managing people in chronic pain often fails to meet the needs of these patients. Novel ways of treating peo...
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| Format: | Article |
| Language: | English |
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South African Medical Association
2023-11-01
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| Series: | South African Medical Journal |
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| Online Access: | https://samajournals.co.za/index.php/samj/article/view/814 |
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| author | J Van Der Walt R Parker |
| author_facet | J Van Der Walt R Parker |
| author_sort | J Van Der Walt |
| collection | DOAJ |
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Healthcare providers face the challenging task of managing patients who suffer from chronic nociplastic pain conditions. Pain is a multidimensional experience, and the current approach to managing people in chronic pain often fails to meet the needs of these patients. Novel ways of treating people who suffer from chronic nociplastic pain with classic psychedelic agents may offer a new lens through which to approach their pain. Lysergic acid diethylamide (LSD) and psilocybin are both serotonergic agents with a long history of use in treating people with chronic pain and mental health disorders. The new wave of research into psychedelics for major depressive disorder provides an opportunity to investigate and understand the potential for incorporating these drugs into chronic pain management pathways. This narrative review presents healthcare workers with a framework to understand the method of action of these drugs in chronic nociplastic pain pathways and a brief history into their use. We conducted an online search using Pubmed with keywords ‘chronic pain’ AND/OR ‘psilocybin’ AND/OR ‘lysergic acid diethylamide’ AND/OR ‘psychedelics’ with no date limit applied. We identified further articles that contained information on the neuroscience of psychedelics and the serotonergic system using Google Scholar. During the final stages of writing the article, the latest publications on psychedelics and chronic pain in leading pain journals were again included to update the information.
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| format | Article |
| id | doaj-art-5b4d8b22373e4e52af4adfec53502858 |
| institution | Kabale University |
| issn | 0256-9574 2078-5135 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | South African Medical Association |
| record_format | Article |
| series | South African Medical Journal |
| spelling | doaj-art-5b4d8b22373e4e52af4adfec535028582025-02-10T12:26:41ZengSouth African Medical AssociationSouth African Medical Journal0256-95742078-51352023-11-011131110.7196/SAMJ.2023.v113i11.814LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic painJ Van Der Walt0R Parker1Department of Anaesthesia and Perioperative Medicine, Faculty of Health Sciences, University of Cape Town, South AfricaDepartment of Anaesthesia and Perioperative Medicine, Faculty of Health Sciences, University of Cape Town, South Africa Healthcare providers face the challenging task of managing patients who suffer from chronic nociplastic pain conditions. Pain is a multidimensional experience, and the current approach to managing people in chronic pain often fails to meet the needs of these patients. Novel ways of treating people who suffer from chronic nociplastic pain with classic psychedelic agents may offer a new lens through which to approach their pain. Lysergic acid diethylamide (LSD) and psilocybin are both serotonergic agents with a long history of use in treating people with chronic pain and mental health disorders. The new wave of research into psychedelics for major depressive disorder provides an opportunity to investigate and understand the potential for incorporating these drugs into chronic pain management pathways. This narrative review presents healthcare workers with a framework to understand the method of action of these drugs in chronic nociplastic pain pathways and a brief history into their use. We conducted an online search using Pubmed with keywords ‘chronic pain’ AND/OR ‘psilocybin’ AND/OR ‘lysergic acid diethylamide’ AND/OR ‘psychedelics’ with no date limit applied. We identified further articles that contained information on the neuroscience of psychedelics and the serotonergic system using Google Scholar. During the final stages of writing the article, the latest publications on psychedelics and chronic pain in leading pain journals were again included to update the information. https://samajournals.co.za/index.php/samj/article/view/814painpsychedelicspsilocybinnociplasticLSD |
| spellingShingle | J Van Der Walt R Parker LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic pain South African Medical Journal pain psychedelics psilocybin nociplastic LSD |
| title | LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic pain |
| title_full | LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic pain |
| title_fullStr | LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic pain |
| title_full_unstemmed | LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic pain |
| title_short | LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic pain |
| title_sort | lsd and psilocybin for chronic nociplastic pain a narrative review of the literature supporting the use of classic psychedelic agents in chronic pain |
| topic | pain psychedelics psilocybin nociplastic LSD |
| url | https://samajournals.co.za/index.php/samj/article/view/814 |
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