Diagnostic value of miR-193a-5p in severe pneumonia and its correlation with prognosis
Abstract Background Severe pneumonia is a common disease in children, with rapid progression and easy complications of respiratory failure, endangering the lives of children. This study aimed to elucidate the clinical significance of miR-193a-5p in severe pneumonia and to provide a new biomarker for...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Cardiothoracic Surgery |
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| Online Access: | https://doi.org/10.1186/s13019-024-03256-y |
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| author | Xiaoji Su Lijuan Zhu Jiajia Zhuo Shihai Zhang |
| author_facet | Xiaoji Su Lijuan Zhu Jiajia Zhuo Shihai Zhang |
| author_sort | Xiaoji Su |
| collection | DOAJ |
| description | Abstract Background Severe pneumonia is a common disease in children, with rapid progression and easy complications of respiratory failure, endangering the lives of children. This study aimed to elucidate the clinical significance of miR-193a-5p in severe pneumonia and to provide a new biomarker for the disease. Methods A total of 150 children with severe pneumonia and an equal number of healthy children were selected for analysis. Serum miR-193a-5p levels were detected by RT-qPCR. The correlation of miR-193a-5p with CRP, WBC, neutrophil count, and NLR was assessed by Spearman analysis. The diagnostic and prognostic value of miR-193a-5p in severe pneumonia was analyzed using ROC curves. The relationship between miR-193a-5p and the prognosis of severe pneumonia was evaluated using the Kaplan-Meier curve and a multivariate logistic analysis. Results Serum levels of miR-193a-5p were markedly elevated in children with severe pneumonia and exhibited a positive correlation with CRP, WBC, neutrophil count, and NLR. miR-193a-5p could effectively distinguish children with severe pneumonia from healthy children, with an AUC, sensitivity, and specificity of 0.862, 70.67%, and 88.67%, respectively. Serum miR-193a-5p expression was increased in children with poor prognosis and had a predictive value for patient prognosis. High expression of miR-193a-5p was linked to survival in children with severe pneumonia and was a risk factor for adverse prognosis. Conclusion Serum levels of miR-193a-5p were markedly elevated in children with severe pneumonia, which may be of significance for the early diagnosis of the disease and prognostic assessment. |
| format | Article |
| id | doaj-art-5b4d25517e9d41dd962a04297b8dadff |
| institution | Kabale University |
| issn | 1749-8090 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj-art-5b4d25517e9d41dd962a04297b8dadff2025-01-26T12:52:00ZengBMCJournal of Cardiothoracic Surgery1749-80902025-01-012011710.1186/s13019-024-03256-yDiagnostic value of miR-193a-5p in severe pneumonia and its correlation with prognosisXiaoji Su0Lijuan Zhu1Jiajia Zhuo2Shihai Zhang3Clinical Laboratory, Anhui Hospital, Children’s Hospital of Fudan UniversityClinical Laboratory, Anhui Hospital, Children’s Hospital of Fudan UniversityClinical Laboratory, Anhui Hospital, Children’s Hospital of Fudan UniversityClinical Laboratory, Anhui Hospital, Children’s Hospital of Fudan UniversityAbstract Background Severe pneumonia is a common disease in children, with rapid progression and easy complications of respiratory failure, endangering the lives of children. This study aimed to elucidate the clinical significance of miR-193a-5p in severe pneumonia and to provide a new biomarker for the disease. Methods A total of 150 children with severe pneumonia and an equal number of healthy children were selected for analysis. Serum miR-193a-5p levels were detected by RT-qPCR. The correlation of miR-193a-5p with CRP, WBC, neutrophil count, and NLR was assessed by Spearman analysis. The diagnostic and prognostic value of miR-193a-5p in severe pneumonia was analyzed using ROC curves. The relationship between miR-193a-5p and the prognosis of severe pneumonia was evaluated using the Kaplan-Meier curve and a multivariate logistic analysis. Results Serum levels of miR-193a-5p were markedly elevated in children with severe pneumonia and exhibited a positive correlation with CRP, WBC, neutrophil count, and NLR. miR-193a-5p could effectively distinguish children with severe pneumonia from healthy children, with an AUC, sensitivity, and specificity of 0.862, 70.67%, and 88.67%, respectively. Serum miR-193a-5p expression was increased in children with poor prognosis and had a predictive value for patient prognosis. High expression of miR-193a-5p was linked to survival in children with severe pneumonia and was a risk factor for adverse prognosis. Conclusion Serum levels of miR-193a-5p were markedly elevated in children with severe pneumonia, which may be of significance for the early diagnosis of the disease and prognostic assessment.https://doi.org/10.1186/s13019-024-03256-ymiR-193a-5pPneumoniaDiagnostic valuePrognosis |
| spellingShingle | Xiaoji Su Lijuan Zhu Jiajia Zhuo Shihai Zhang Diagnostic value of miR-193a-5p in severe pneumonia and its correlation with prognosis Journal of Cardiothoracic Surgery miR-193a-5p Pneumonia Diagnostic value Prognosis |
| title | Diagnostic value of miR-193a-5p in severe pneumonia and its correlation with prognosis |
| title_full | Diagnostic value of miR-193a-5p in severe pneumonia and its correlation with prognosis |
| title_fullStr | Diagnostic value of miR-193a-5p in severe pneumonia and its correlation with prognosis |
| title_full_unstemmed | Diagnostic value of miR-193a-5p in severe pneumonia and its correlation with prognosis |
| title_short | Diagnostic value of miR-193a-5p in severe pneumonia and its correlation with prognosis |
| title_sort | diagnostic value of mir 193a 5p in severe pneumonia and its correlation with prognosis |
| topic | miR-193a-5p Pneumonia Diagnostic value Prognosis |
| url | https://doi.org/10.1186/s13019-024-03256-y |
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