A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases
Tripartite motif (TRIM) proteins comprise an important class of E3 ubiquitin ligases that regulate numerous biological processes including protein expression, cellular signaling pathways, and innate immunity. This ubiquitous participation in fundamental aspects of biology has made TRIM proteins a fo...
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MDPI AG
2025-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/17/4/562 |
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| author | Adam Hage Mikhaila Janes Sonja M. Best |
| author_facet | Adam Hage Mikhaila Janes Sonja M. Best |
| author_sort | Adam Hage |
| collection | DOAJ |
| description | Tripartite motif (TRIM) proteins comprise an important class of E3 ubiquitin ligases that regulate numerous biological processes including protein expression, cellular signaling pathways, and innate immunity. This ubiquitous participation in fundamental aspects of biology has made TRIM proteins a focus of study in many fields and has illuminated the negative impact they exert when functioning improperly. Disruption of TRIM function has been linked to the success of various pathogens and separately to the occurrence and development of several neurodegenerative diseases, making TRIM proteins an appealing candidate to study for novel therapeutic approaches. Here, we review the current findings on TRIM proteins that demonstrate their analogous properties in the distinct fields of viral infection and central nervous system (CNS) disorders. We also examine recent advancements in drug development and targeted protein degradation as potential strategies for TRIM-mediated therapeutic treatments and discuss the implications these technologies have on future research directions. |
| format | Article |
| id | doaj-art-5b4b63ad1b8e4615b2df6b28dc9fda5e |
| institution | OA Journals |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-5b4b63ad1b8e4615b2df6b28dc9fda5e2025-08-20T02:18:11ZengMDPI AGViruses1999-49152025-04-0117456210.3390/v17040562A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System DiseasesAdam Hage0Mikhaila Janes1Sonja M. Best2Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Division of Intramural Research, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USAInnate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Division of Intramural Research, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USAInnate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Division of Intramural Research, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USATripartite motif (TRIM) proteins comprise an important class of E3 ubiquitin ligases that regulate numerous biological processes including protein expression, cellular signaling pathways, and innate immunity. This ubiquitous participation in fundamental aspects of biology has made TRIM proteins a focus of study in many fields and has illuminated the negative impact they exert when functioning improperly. Disruption of TRIM function has been linked to the success of various pathogens and separately to the occurrence and development of several neurodegenerative diseases, making TRIM proteins an appealing candidate to study for novel therapeutic approaches. Here, we review the current findings on TRIM proteins that demonstrate their analogous properties in the distinct fields of viral infection and central nervous system (CNS) disorders. We also examine recent advancements in drug development and targeted protein degradation as potential strategies for TRIM-mediated therapeutic treatments and discuss the implications these technologies have on future research directions.https://www.mdpi.com/1999-4915/17/4/562ubiquitintripartite motif (TRIM)E3 ubiquitin ligasePROTACprotein degradationCNS diseases |
| spellingShingle | Adam Hage Mikhaila Janes Sonja M. Best A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases Viruses ubiquitin tripartite motif (TRIM) E3 ubiquitin ligase PROTAC protein degradation CNS diseases |
| title | A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases |
| title_full | A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases |
| title_fullStr | A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases |
| title_full_unstemmed | A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases |
| title_short | A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases |
| title_sort | no brainer the therapeutic potential of trim proteins in viral and central nervous system diseases |
| topic | ubiquitin tripartite motif (TRIM) E3 ubiquitin ligase PROTAC protein degradation CNS diseases |
| url | https://www.mdpi.com/1999-4915/17/4/562 |
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