Tumor irradiation induced immunogenic response: the impact of DNA damage induction and misrepair

Tumor irradiation induced immunogenic response: the impact of DNA damage induction and misrepair

Abstract Focal tumor irradiation, a cornerstone of cancer therapy, has been increasingly recognized for its capacity to provoke systemic immunogenic responses that extend beyond localized tumor control. Recent advances highlight DNA damage, especially DNA double-strand breaks (DSBs), as a central me...

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Bibliographic Details
Main Authors: Qi Liu, Xiaoran Shi, Nilupaier Tayier, Lin Ma
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Radiation Oncology
Subjects:
Radiotherapy
DNA double strand breaks
DNA damage misrepair
Genome instability
Tumor immunogenicity.
Online Access:https://doi.org/10.1186/s13014-025-02711-x
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