In vitro pharmacological activities and phytochemical investigation of Cinnamomum walaiwarense Kosterm
Cinnamon trees are small evergreens with aromatic bark and leaves. The spice, consisting of the dried inner aromatic bark, brown in color and has a delicately fragrant aroma. The present study explores pharmacological properties of Lauraceae Family - Cinnamomum walaiwarense, a lesser-known and criti...
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Elsevier
2025-12-01
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| Series: | Chemical Physics Impact |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266702242500091X |
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| author | M. Manojkumar M. Mayilsamy |
| author_facet | M. Manojkumar M. Mayilsamy |
| author_sort | M. Manojkumar |
| collection | DOAJ |
| description | Cinnamon trees are small evergreens with aromatic bark and leaves. The spice, consisting of the dried inner aromatic bark, brown in color and has a delicately fragrant aroma. The present study explores pharmacological properties of Lauraceae Family - Cinnamomum walaiwarense, a lesser-known and critically endangered species, is endemic to the biodiverse South-Western Ghats of India. The spices from the dried inner bark, is brown with a sweet, aromatic fragrance. Bark samples were sequentially extracted in organic solvents ethylacetate into five different concentrations. The resulting extracts were evaluated for presence of secondary metabolites through standard phytochemical assays. Saponins were identified as the most abundant phytoconstituents, along with other known compounds. To assess the therapeutic significance of secondary metabolites, the ethyl acetate extract further examined for anti-cancer, anti-inflammatory, antioxidant, and anti-diabetic properties through established in-vitro assays. The extract demonstrated promising bioactivity across the carried assays, suggesting a broad-spectrum pharmacological potential. These findings reveals valuable preliminary evidence supporting the medicinal significance of C. walaiwarense, while also underpinning the ecological determination of conserving this rare endemic species. This study supports further pure compound isolation and in-vivo validation, spotlighting the untapped therapeutic potential of the underexplored species |
| format | Article |
| id | doaj-art-5b40ae6f7a004953ad2f494e9d296b60 |
| institution | Kabale University |
| issn | 2667-0224 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
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| series | Chemical Physics Impact |
| spelling | doaj-art-5b40ae6f7a004953ad2f494e9d296b602025-08-20T03:31:28ZengElsevierChemical Physics Impact2667-02242025-12-011110090510.1016/j.chphi.2025.100905In vitro pharmacological activities and phytochemical investigation of Cinnamomum walaiwarense KostermM. Manojkumar0M. Mayilsamy1Department of Plant Sciences, School of Biological Sciences, Madurai Kamaraj University, Madurai - 625 021, Tamilnadu, IndiaPG & Research Department of Botany, Arulmigu Palaniandavar College of Arts and Culture, Palani - 624 601, Tamilnadu, India; Corresponding author.Cinnamon trees are small evergreens with aromatic bark and leaves. The spice, consisting of the dried inner aromatic bark, brown in color and has a delicately fragrant aroma. The present study explores pharmacological properties of Lauraceae Family - Cinnamomum walaiwarense, a lesser-known and critically endangered species, is endemic to the biodiverse South-Western Ghats of India. The spices from the dried inner bark, is brown with a sweet, aromatic fragrance. Bark samples were sequentially extracted in organic solvents ethylacetate into five different concentrations. The resulting extracts were evaluated for presence of secondary metabolites through standard phytochemical assays. Saponins were identified as the most abundant phytoconstituents, along with other known compounds. To assess the therapeutic significance of secondary metabolites, the ethyl acetate extract further examined for anti-cancer, anti-inflammatory, antioxidant, and anti-diabetic properties through established in-vitro assays. The extract demonstrated promising bioactivity across the carried assays, suggesting a broad-spectrum pharmacological potential. These findings reveals valuable preliminary evidence supporting the medicinal significance of C. walaiwarense, while also underpinning the ecological determination of conserving this rare endemic species. This study supports further pure compound isolation and in-vivo validation, spotlighting the untapped therapeutic potential of the underexplored specieshttp://www.sciencedirect.com/science/article/pii/S266702242500091XCinnamonSecondary metabolitesPharmacologyInvitro assaysConservation |
| spellingShingle | M. Manojkumar M. Mayilsamy In vitro pharmacological activities and phytochemical investigation of Cinnamomum walaiwarense Kosterm Chemical Physics Impact Cinnamon Secondary metabolites Pharmacology Invitro assays Conservation |
| title | In vitro pharmacological activities and phytochemical investigation of Cinnamomum walaiwarense Kosterm |
| title_full | In vitro pharmacological activities and phytochemical investigation of Cinnamomum walaiwarense Kosterm |
| title_fullStr | In vitro pharmacological activities and phytochemical investigation of Cinnamomum walaiwarense Kosterm |
| title_full_unstemmed | In vitro pharmacological activities and phytochemical investigation of Cinnamomum walaiwarense Kosterm |
| title_short | In vitro pharmacological activities and phytochemical investigation of Cinnamomum walaiwarense Kosterm |
| title_sort | in vitro pharmacological activities and phytochemical investigation of cinnamomum walaiwarense kosterm |
| topic | Cinnamon Secondary metabolites Pharmacology Invitro assays Conservation |
| url | http://www.sciencedirect.com/science/article/pii/S266702242500091X |
| work_keys_str_mv | AT mmanojkumar invitropharmacologicalactivitiesandphytochemicalinvestigationofcinnamomumwalaiwarensekosterm AT mmayilsamy invitropharmacologicalactivitiesandphytochemicalinvestigationofcinnamomumwalaiwarensekosterm |