Whipple's disease: A case report
Introduction. Whipple's disease is a chronic, multisystem, infectious disease caused by Tropheryma whipplei. It most commonly affects Caucasian males, middle-aged. Morbus Whipple is primarily gastrointestinal disease, manifested as malabsorption syndrome, and diagnosed by endoscopy and intes...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2012-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2012/0042-84501206522P.pdf |
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| author | Popović Dušan Đ. Špuran Milan Jovanović Ivan Alempijević Tamara Đuranović Srđan Kovačević Nada Micev Marjan Krstić Miodrag |
| author_facet | Popović Dušan Đ. Špuran Milan Jovanović Ivan Alempijević Tamara Đuranović Srđan Kovačević Nada Micev Marjan Krstić Miodrag |
| author_sort | Popović Dušan Đ. |
| collection | DOAJ |
| description | Introduction. Whipple's disease is a chronic, multisystem, infectious disease caused by Tropheryma whipplei. It most commonly affects Caucasian males, middle-aged. Morbus Whipple is primarily gastrointestinal disease, manifested as malabsorption syndrome, and diagnosed by endoscopy and intestinal biopsy. Extraintestinal manifestations are not rare. Case report. A 48-year-old male was admitted due to diarrhea, weight loss and weakness in the extremities. Physical examination findings pointed out diffuse hyperpigmentation, pleural effusion and leg edema. Anemia, inflammatory syndrome and malabsorption signs were discovered through laboratory tests. The diagnosis was confirmed by intestinal biopsy. The patient was treated with antibiotic and symptomatic therapy. After 9 months, the patient had no symptoms, and clinical and laboratory findings were regular. Conclusion. Whipple's disease is a rare disease. A high degree of clinical suspicion for the disease (malabsorption, arthritis, fever, neurological symptoms) is the most important for diagnosis. Timely diagnosis and appropriate therapy prevent the disease progression and fatal outcome. |
| format | Article |
| id | doaj-art-5b36d3a100814d77b0ba65d365fbf02c |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-5b36d3a100814d77b0ba65d365fbf02c2025-08-20T01:57:32ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502012-01-0169652252510.2298/VSP1206522PWhipple's disease: A case reportPopović Dušan Đ.Špuran MilanJovanović IvanAlempijević TamaraĐuranović SrđanKovačević NadaMicev MarjanKrstić MiodragIntroduction. Whipple's disease is a chronic, multisystem, infectious disease caused by Tropheryma whipplei. It most commonly affects Caucasian males, middle-aged. Morbus Whipple is primarily gastrointestinal disease, manifested as malabsorption syndrome, and diagnosed by endoscopy and intestinal biopsy. Extraintestinal manifestations are not rare. Case report. A 48-year-old male was admitted due to diarrhea, weight loss and weakness in the extremities. Physical examination findings pointed out diffuse hyperpigmentation, pleural effusion and leg edema. Anemia, inflammatory syndrome and malabsorption signs were discovered through laboratory tests. The diagnosis was confirmed by intestinal biopsy. The patient was treated with antibiotic and symptomatic therapy. After 9 months, the patient had no symptoms, and clinical and laboratory findings were regular. Conclusion. Whipple's disease is a rare disease. A high degree of clinical suspicion for the disease (malabsorption, arthritis, fever, neurological symptoms) is the most important for diagnosis. Timely diagnosis and appropriate therapy prevent the disease progression and fatal outcome.http://www.doiserbia.nb.rs/img/doi/0042-8450/2012/0042-84501206522P.pdfwhiplle diseasediagnosismalabsorption syndromesanemiabiopsyintestine, smalltreatment outcome |
| spellingShingle | Popović Dušan Đ. Špuran Milan Jovanović Ivan Alempijević Tamara Đuranović Srđan Kovačević Nada Micev Marjan Krstić Miodrag Whipple's disease: A case report Vojnosanitetski Pregled whiplle disease diagnosis malabsorption syndromes anemia biopsy intestine, small treatment outcome |
| title | Whipple's disease: A case report |
| title_full | Whipple's disease: A case report |
| title_fullStr | Whipple's disease: A case report |
| title_full_unstemmed | Whipple's disease: A case report |
| title_short | Whipple's disease: A case report |
| title_sort | whipple s disease a case report |
| topic | whiplle disease diagnosis malabsorption syndromes anemia biopsy intestine, small treatment outcome |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2012/0042-84501206522P.pdf |
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