Clinical study of calprotectin in gout and its complications
Objective To explore the role of calprotectin in gout and its complications. Methods A total of 49 patients with gouty arthritis were selected, including 24 patients with acute attack of gout, 25 patients with remission of gout and 40 healthy controls. Serum calprotectin levels were detected by enzy...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2021-01-01
|
| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57904167&Fpath=home&index=0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850186959862890496 |
|---|---|
| author | Ren Qi-jie Wei Xiao-fei Chen Xing-guo Shen Min-ning |
| author_facet | Ren Qi-jie Wei Xiao-fei Chen Xing-guo Shen Min-ning |
| author_sort | Ren Qi-jie |
| collection | DOAJ |
| description | Objective To explore the role of calprotectin in gout and its complications. Methods A total of 49 patients with gouty arthritis were selected, including 24 patients with acute attack of gout, 25 patients with remission of gout and 40 healthy controls. Serum calprotectin levels were detected by enzyme-linked immunosorbent assay（ELISA）. The differences of calprotectin levels were compared between healthy control, patients with acute gout attack and remission. And the correlations were examined between calprotectin level and serum levels of creatinine and urea nitrogen in gout patients. Concurrently, the changes of serum calprotectin level in gout patients with or without kidney stones and fatty liver were further analyzed. Results As compared with control group, the level of calprotectin spiked markedly in gout group [7075.6（5095.59316.8）vs 2831.2（2124.83334.8）,P<0.01]and the level of calprotectin was significantly lower in remission group than that in acute attack group. The serum creatinine level was significantly higher in gout than that in control group（85.39± 15.21 vs 70.86±12.85,P=0.025）. Although no significant inter-group difference existed in urea nitrogen level, urea nitrogen level showed a rising trend in gout group（5.45±1.52 vs 4.47±1.12,P=0.075）. Serum calprotectin level was positively correlated with serum creatinine level（r=0.396,P=0.012）,but not with urea nitrogen level（r=-0.150,P=0.363）. In gout group, no significant difference existed in calprotectin concentration between patients with and without kidney stones [5873.6（3191.210712.0）vs 7095.4（5171.69357.2）,P=0.524]while calprotectin level was significantly higher in patients with fatty liver than that in those without fatty liver [11515.6（6497.213320.4）vs 5873.6（3191.2,10712.0）,P=0.002]. Conclusion Involved probably in the pathogenesis of gout, calprotectin has a certain predictive effect on acute attack of gout. As for the complications of gout, calprotectin may be correlated with the formation of acute kidney injury and fatty liver. However, its role in the formation of kidney stones should be further explored. |
| format | Article |
| id | doaj-art-5b30a13ff18d4ea0878cd885855b56a6 |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2021-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-5b30a13ff18d4ea0878cd885855b56a62025-08-20T02:16:13ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902021-01-0139239657904167Clinical study of calprotectin in gout and its complicationsRen Qi-jieWei Xiao-feiChen Xing-guoShen Min-ningObjective To explore the role of calprotectin in gout and its complications. Methods A total of 49 patients with gouty arthritis were selected, including 24 patients with acute attack of gout, 25 patients with remission of gout and 40 healthy controls. Serum calprotectin levels were detected by enzyme-linked immunosorbent assay（ELISA）. The differences of calprotectin levels were compared between healthy control, patients with acute gout attack and remission. And the correlations were examined between calprotectin level and serum levels of creatinine and urea nitrogen in gout patients. Concurrently, the changes of serum calprotectin level in gout patients with or without kidney stones and fatty liver were further analyzed. Results As compared with control group, the level of calprotectin spiked markedly in gout group [7075.6（5095.59316.8）vs 2831.2（2124.83334.8）,P<0.01]and the level of calprotectin was significantly lower in remission group than that in acute attack group. The serum creatinine level was significantly higher in gout than that in control group（85.39± 15.21 vs 70.86±12.85,P=0.025）. Although no significant inter-group difference existed in urea nitrogen level, urea nitrogen level showed a rising trend in gout group（5.45±1.52 vs 4.47±1.12,P=0.075）. Serum calprotectin level was positively correlated with serum creatinine level（r=0.396,P=0.012）,but not with urea nitrogen level（r=-0.150,P=0.363）. In gout group, no significant difference existed in calprotectin concentration between patients with and without kidney stones [5873.6（3191.210712.0）vs 7095.4（5171.69357.2）,P=0.524]while calprotectin level was significantly higher in patients with fatty liver than that in those without fatty liver [11515.6（6497.213320.4）vs 5873.6（3191.2,10712.0）,P=0.002]. Conclusion Involved probably in the pathogenesis of gout, calprotectin has a certain predictive effect on acute attack of gout. As for the complications of gout, calprotectin may be correlated with the formation of acute kidney injury and fatty liver. However, its role in the formation of kidney stones should be further explored.http://www.lcszb.com/thesisDetails?columnId=57904167&Fpath=home&index=0CalprotectinGoutComplicationsAcute kidney injuryFatty liverKidney calculi |
| spellingShingle | Ren Qi-jie Wei Xiao-fei Chen Xing-guo Shen Min-ning Clinical study of calprotectin in gout and its complications Linchuang shenzangbing zazhi Calprotectin Gout Complications Acute kidney injury Fatty liver Kidney calculi |
| title | Clinical study of calprotectin in gout and its complications |
| title_full | Clinical study of calprotectin in gout and its complications |
| title_fullStr | Clinical study of calprotectin in gout and its complications |
| title_full_unstemmed | Clinical study of calprotectin in gout and its complications |
| title_short | Clinical study of calprotectin in gout and its complications |
| title_sort | clinical study of calprotectin in gout and its complications |
| topic | Calprotectin Gout Complications Acute kidney injury Fatty liver Kidney calculi |
| url | http://www.lcszb.com/thesisDetails?columnId=57904167&Fpath=home&index=0 |
| work_keys_str_mv | AT renqijie clinicalstudyofcalprotectiningoutanditscomplications AT weixiaofei clinicalstudyofcalprotectiningoutanditscomplications AT chenxingguo clinicalstudyofcalprotectiningoutanditscomplications AT shenminning clinicalstudyofcalprotectiningoutanditscomplications |