Orbital Neurolymphomatosis in Patient with CNS Lymphoma
Neurolymphomatosis (NL) is a rare manifestation of hematologic malignancies, characterized by a neoplastic infiltration of the peripheral nervous system and cranial nerves (CNs). Non-Hodgkin lymphomas (NHLs) account for 90% of NL cases, while acute leukemia represents 10% of the cases. NL can occur...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/15/6/780 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849341421930151936 |
|---|---|
| author | Tara Shooshani Michael Han Jeremiah P. Tao Samuel J. Spiegel Maria Del Valle Estopinal |
| author_facet | Tara Shooshani Michael Han Jeremiah P. Tao Samuel J. Spiegel Maria Del Valle Estopinal |
| author_sort | Tara Shooshani |
| collection | DOAJ |
| description | Neurolymphomatosis (NL) is a rare manifestation of hematologic malignancies, characterized by a neoplastic infiltration of the peripheral nervous system and cranial nerves (CNs). Non-Hodgkin lymphomas (NHLs) account for 90% of NL cases, while acute leukemia represents 10% of the cases. NL can occur as the first manifestation of a malignancy (primary), or as a relapse or progression of a previously treated disease (secondary). Herein, we report a unique case of NL involving the left orbit and CNs in a 74-year-old female with primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL). Our patient developed secondary neurolymphomatosis involving the left orbit and CNs II, III, V, and VI, supported by clinical, radiologic, and histologic findings. The lacrimal gland enhancement was histopathologically proven to be caused by the direct spread of CNS DLBCL to the lacrimal nerve, a branch of CN V, identifying NL as one of the conditions that can affect this organ. The lacrimal gland could be considered as a more accessible biopsy site when the involvement of CN V is suspected. |
| format | Article |
| id | doaj-art-5b2ae63b931d486d923971097b37f2f1 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-5b2ae63b931d486d923971097b37f2f12025-08-20T03:43:37ZengMDPI AGDiagnostics2075-44182025-03-0115678010.3390/diagnostics15060780Orbital Neurolymphomatosis in Patient with CNS LymphomaTara Shooshani0Michael Han1Jeremiah P. Tao2Samuel J. Spiegel3Maria Del Valle Estopinal4School of Medicine, University of California, Irvine, CA 92697, USADepartment of Ophthalmology, University of California, Irvine, CA 92697, USADepartment of Ophthalmology, University of California, Irvine, CA 92697, USADepartment of Ophthalmology, University of California, Irvine, CA 92697, USADepartment of Ophthalmology, University of California, Irvine, CA 92697, USANeurolymphomatosis (NL) is a rare manifestation of hematologic malignancies, characterized by a neoplastic infiltration of the peripheral nervous system and cranial nerves (CNs). Non-Hodgkin lymphomas (NHLs) account for 90% of NL cases, while acute leukemia represents 10% of the cases. NL can occur as the first manifestation of a malignancy (primary), or as a relapse or progression of a previously treated disease (secondary). Herein, we report a unique case of NL involving the left orbit and CNs in a 74-year-old female with primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL). Our patient developed secondary neurolymphomatosis involving the left orbit and CNs II, III, V, and VI, supported by clinical, radiologic, and histologic findings. The lacrimal gland enhancement was histopathologically proven to be caused by the direct spread of CNS DLBCL to the lacrimal nerve, a branch of CN V, identifying NL as one of the conditions that can affect this organ. The lacrimal gland could be considered as a more accessible biopsy site when the involvement of CN V is suspected.https://www.mdpi.com/2075-4418/15/6/780neurolymphomatosisCNS lymphomahistopathology |
| spellingShingle | Tara Shooshani Michael Han Jeremiah P. Tao Samuel J. Spiegel Maria Del Valle Estopinal Orbital Neurolymphomatosis in Patient with CNS Lymphoma Diagnostics neurolymphomatosis CNS lymphoma histopathology |
| title | Orbital Neurolymphomatosis in Patient with CNS Lymphoma |
| title_full | Orbital Neurolymphomatosis in Patient with CNS Lymphoma |
| title_fullStr | Orbital Neurolymphomatosis in Patient with CNS Lymphoma |
| title_full_unstemmed | Orbital Neurolymphomatosis in Patient with CNS Lymphoma |
| title_short | Orbital Neurolymphomatosis in Patient with CNS Lymphoma |
| title_sort | orbital neurolymphomatosis in patient with cns lymphoma |
| topic | neurolymphomatosis CNS lymphoma histopathology |
| url | https://www.mdpi.com/2075-4418/15/6/780 |
| work_keys_str_mv | AT tarashooshani orbitalneurolymphomatosisinpatientwithcnslymphoma AT michaelhan orbitalneurolymphomatosisinpatientwithcnslymphoma AT jeremiahptao orbitalneurolymphomatosisinpatientwithcnslymphoma AT samueljspiegel orbitalneurolymphomatosisinpatientwithcnslymphoma AT mariadelvalleestopinal orbitalneurolymphomatosisinpatientwithcnslymphoma |