CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Abstract. We studied cytokine profile in blood and exhaled breath condensate (EBC) in patients with chronic obstructive pulmonary disease (COPD) being in remission state. It is shown that pro- and anti-inflammatory cytokine contents depended on the disease severity, both in whole blood and EBC of th...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/590 |
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| author | E. Р. Kalinina Е. Г. Лобанова |
| author_facet | E. Р. Kalinina Е. Г. Лобанова |
| author_sort | E. Р. Kalinina |
| collection | DOAJ |
| description | Abstract. We studied cytokine profile in blood and exhaled breath condensate (EBC) in patients with chronic obstructive pulmonary disease (COPD) being in remission state. It is shown that pro- and anti-inflammatory cytokine contents depended on the disease severity, both in whole blood and EBC of the COPD patients. We have revealed an increase in TNFα, s-TNFα RI, TGF-β1 and bFGF in EBC of patients with COPD manifestations, thus being indicative for progression of metabolic changes in lung tissue, and advanced stage of respiratory functional disturbances. Cytokine profile abnormalities in COPD patients resulting, in part, from systemic and local disorders of cellular immunity, represent a major pathogenetic mechanism determining the disease progression. |
| format | Article |
| id | doaj-art-5b1e1272faee4c848fa4d57ac794bcb5 |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-5b1e1272faee4c848fa4d57ac794bcb52025-08-20T03:37:46ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0114650150610.15789/1563-0625-2012-6-501-506587CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASEE. Р. Kalinina0Е. Г. Лобанова1Владивостокский филиал Федерального государственного бюджетного учреждения «Дальневосточный научный центр физиологии и патологии дыхания» СО РАМН – НИИ медицинской климатологии и восстановительного лечения, г. ВладивостокВладивостокский филиал Федерального государственного бюджетного учреждения «Дальневосточный научный центр физиологии и патологии дыхания» СО РАМН – НИИ медицинской климатологии и восстановительного лечения, г. ВладивостокAbstract. We studied cytokine profile in blood and exhaled breath condensate (EBC) in patients with chronic obstructive pulmonary disease (COPD) being in remission state. It is shown that pro- and anti-inflammatory cytokine contents depended on the disease severity, both in whole blood and EBC of the COPD patients. We have revealed an increase in TNFα, s-TNFα RI, TGF-β1 and bFGF in EBC of patients with COPD manifestations, thus being indicative for progression of metabolic changes in lung tissue, and advanced stage of respiratory functional disturbances. Cytokine profile abnormalities in COPD patients resulting, in part, from systemic and local disorders of cellular immunity, represent a major pathogenetic mechanism determining the disease progression.https://www.mimmun.ru/mimmun/article/view/590chronic obstructive pulmonary diseasecytokine profilerespiratory functionmetabolic changes |
| spellingShingle | E. Р. Kalinina Е. Г. Лобанова CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE Медицинская иммунология chronic obstructive pulmonary disease cytokine profile respiratory function metabolic changes |
| title | CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_full | CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_fullStr | CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_full_unstemmed | CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_short | CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_sort | cytokine profile features in patients with chronic obstructive pulmonary disease |
| topic | chronic obstructive pulmonary disease cytokine profile respiratory function metabolic changes |
| url | https://www.mimmun.ru/mimmun/article/view/590 |
| work_keys_str_mv | AT erkalinina cytokineprofilefeaturesinpatientswithchronicobstructivepulmonarydisease AT eglobanova cytokineprofilefeaturesinpatientswithchronicobstructivepulmonarydisease |