Mitochondrial DNA Depletion Reduces PARP-1 Levels and Promotes Progression of the Neoplastic Phenotype in Prostate Carcinoma

Mitochondrial DNA Depletion Reduces PARP-1 Levels and Promotes Progression of the Neoplastic Phenotype in Prostate Carcinoma

Mitochondrial dysfunction resulting from mitochondrial DNA (mtDNA) mutations and/or depletion has been correlated with cancer progression and drug resistance. To investigate the role of mtDNA in prostate cancer progression, we used LNCaP and PC-3 prostate carcinoma cells as experimental model. Compa...

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Bibliographic Details
Main Authors: Loredana Moro, Arnaldo A. Arbini, Ersilia Marra, Margherita Greco
Format: Article
Language:English
Published: Wiley 2008-01-01
Series:Cellular Oncology
Online Access:http://dx.doi.org/10.3233/CLO-2008-0427
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