Amoxicillin-clavulanic Acid and Trimethoprim/Sulphamethoxazole Combination Therapy for Actinomycetoma in an Elderly Farmer: A Case Report
Actinomycetoma is a chronic, localised, progressive granulomatous infection of the skin and subcutaneous tissues, typically affecting the lower extremities. It is caused by Actinomycetes bacteria, which are commonly found in soil and water. The infection usually results from minor trauma, such as wa...
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JCDR Research and Publications Private Limited
2025-05-01
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| Online Access: | https://jcdr.net/articles/PDF/20959/78910_CE[Ra1]_F(IS)_QC(PS_OM)_PF1(AG_SL)_PFA(IS)_PB(AG_IS)_PN(IS).pdf |
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| author | Sandra Arora Jahanvi Goyal Sanjeev B Gupta Aayush Gupta |
| author_facet | Sandra Arora Jahanvi Goyal Sanjeev B Gupta Aayush Gupta |
| author_sort | Sandra Arora |
| collection | DOAJ |
| description | Actinomycetoma is a chronic, localised, progressive granulomatous infection of the skin and subcutaneous tissues, typically affecting the lower extremities. It is caused by Actinomycetes bacteria, which are commonly found in soil and water. The infection usually results from minor trauma, such as walking barefoot or exposure to thorny vegetation. Upon inoculation, the bacteria form grains that help evade the host immune response, facilitating the establishment of infection. It is characterised by discharging sinuses and the presence of granules. This condition predominantly affects individuals in rural, resource-limited areas with limited access to healthcare. Although it affects both men and women, men are more commonly affected due to occupational exposure. The disease progresses slowly, often leading to severe complications, including tissue destruction and sinus tract formation, with amputation being the only option in advanced cases. Authors hereby report a case of Actinomycetoma in an 86-year-old male farmer who presented with painful erythematous nodules and purulent discharge from lesions on his left leg for the past four years. The diagnosis was established through clinical, histopathological and microbiological investigations, including Gram stain, Gomori Methenamine Silver (GMS), and Periodic Acid-Schiff (PAS) stain. Treatment with a combination of amoxicillin-clavulanic acid and trimethoprim/sulphamethoxazole was initiated. This led to a complete resolution of the condition within three weeks, demonstrating the efficacy of this treatment as a safe and cost-effective option. This case highlights the importance of early diagnosis and appropriate treatment for Actinomycetoma, emphasising the value of affordable therapeutic interventions. |
| format | Article |
| id | doaj-art-5b0a9d6ddce140ccbdf7a90d1635a093 |
| institution | Kabale University |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-5b0a9d6ddce140ccbdf7a90d1635a0932025-08-20T03:47:32ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2025-05-01195WD01WD0310.7860/JCDR/2025/78910.20959Amoxicillin-clavulanic Acid and Trimethoprim/Sulphamethoxazole Combination Therapy for Actinomycetoma in an Elderly Farmer: A Case ReportSandra Arora0Jahanvi Goyal1Sanjeev B Gupta2Aayush Gupta3Junior Resident, Department of Dermatology, Venereology, Leprosy, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, Maharashtra, India.Junior Resident, Department of Dermatology, Venereology, Leprosy, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, Maharashtra, India.Professor, Department of Dermatology, Venereology, Leprosy, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, Maharashtra, India.Professor and Head, Department of Dermatology, Venereology, Leprosy, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, Maharashtra, India.Actinomycetoma is a chronic, localised, progressive granulomatous infection of the skin and subcutaneous tissues, typically affecting the lower extremities. It is caused by Actinomycetes bacteria, which are commonly found in soil and water. The infection usually results from minor trauma, such as walking barefoot or exposure to thorny vegetation. Upon inoculation, the bacteria form grains that help evade the host immune response, facilitating the establishment of infection. It is characterised by discharging sinuses and the presence of granules. This condition predominantly affects individuals in rural, resource-limited areas with limited access to healthcare. Although it affects both men and women, men are more commonly affected due to occupational exposure. The disease progresses slowly, often leading to severe complications, including tissue destruction and sinus tract formation, with amputation being the only option in advanced cases. Authors hereby report a case of Actinomycetoma in an 86-year-old male farmer who presented with painful erythematous nodules and purulent discharge from lesions on his left leg for the past four years. The diagnosis was established through clinical, histopathological and microbiological investigations, including Gram stain, Gomori Methenamine Silver (GMS), and Periodic Acid-Schiff (PAS) stain. Treatment with a combination of amoxicillin-clavulanic acid and trimethoprim/sulphamethoxazole was initiated. This led to a complete resolution of the condition within three weeks, demonstrating the efficacy of this treatment as a safe and cost-effective option. This case highlights the importance of early diagnosis and appropriate treatment for Actinomycetoma, emphasising the value of affordable therapeutic interventions.https://jcdr.net/articles/PDF/20959/78910_CE[Ra1]_F(IS)_QC(PS_OM)_PF1(AG_SL)_PFA(IS)_PB(AG_IS)_PN(IS).pdfchronic granulomatous infectionsinus tractssubcutaneous nodules |
| spellingShingle | Sandra Arora Jahanvi Goyal Sanjeev B Gupta Aayush Gupta Amoxicillin-clavulanic Acid and Trimethoprim/Sulphamethoxazole Combination Therapy for Actinomycetoma in an Elderly Farmer: A Case Report Journal of Clinical and Diagnostic Research chronic granulomatous infection sinus tracts subcutaneous nodules |
| title | Amoxicillin-clavulanic Acid and Trimethoprim/Sulphamethoxazole Combination Therapy for Actinomycetoma in an Elderly Farmer: A Case Report |
| title_full | Amoxicillin-clavulanic Acid and Trimethoprim/Sulphamethoxazole Combination Therapy for Actinomycetoma in an Elderly Farmer: A Case Report |
| title_fullStr | Amoxicillin-clavulanic Acid and Trimethoprim/Sulphamethoxazole Combination Therapy for Actinomycetoma in an Elderly Farmer: A Case Report |
| title_full_unstemmed | Amoxicillin-clavulanic Acid and Trimethoprim/Sulphamethoxazole Combination Therapy for Actinomycetoma in an Elderly Farmer: A Case Report |
| title_short | Amoxicillin-clavulanic Acid and Trimethoprim/Sulphamethoxazole Combination Therapy for Actinomycetoma in an Elderly Farmer: A Case Report |
| title_sort | amoxicillin clavulanic acid and trimethoprim sulphamethoxazole combination therapy for actinomycetoma in an elderly farmer a case report |
| topic | chronic granulomatous infection sinus tracts subcutaneous nodules |
| url | https://jcdr.net/articles/PDF/20959/78910_CE[Ra1]_F(IS)_QC(PS_OM)_PF1(AG_SL)_PFA(IS)_PB(AG_IS)_PN(IS).pdf |
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