Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends
The endometrium plays a fundamental role in the reproductive system yet many etiologies of infertility-related endometrial diseases such as endometriosis, adenomyosis, Asherman’s syndrome or endometrial cancer remain unknown. There are currently no treatments that minimize the effects of this devast...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1495338/full |
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| author | Marcos Agustina-Hernández Emilio Francés-Herrero María Gómez-Álvarez Paula Alonso-Frías Mónica Romeu Ana Monzó Hortensia Ferrero Clara Bueno-Fernandez Clara Bueno-Fernandez Irene Cervelló |
| author_facet | Marcos Agustina-Hernández Emilio Francés-Herrero María Gómez-Álvarez Paula Alonso-Frías Mónica Romeu Ana Monzó Hortensia Ferrero Clara Bueno-Fernandez Clara Bueno-Fernandez Irene Cervelló |
| author_sort | Marcos Agustina-Hernández |
| collection | DOAJ |
| description | The endometrium plays a fundamental role in the reproductive system yet many etiologies of infertility-related endometrial diseases such as endometriosis, adenomyosis, Asherman’s syndrome or endometrial cancer remain unknown. There are currently no treatments that minimize the effects of this devastating disorder. Appropriate model systems that closely mimic the architecture and function of the endometrium in healthy and pathological states are needed to understand the underlying molecular pathways and develop novel or more effective treatments. This review summarizes the key milestones of in vitro culture models of the human endometrium throughout history, as well as the applications of advanced bioengineering techniques in the modelling of both healthy and pathological endometrium. Opportunities for future approaches are also discussed. |
| format | Article |
| id | doaj-art-5b0850937591452d930e5df7e2a8197c |
| institution | DOAJ |
| issn | 2296-4185 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-5b0850937591452d930e5df7e2a8197c2025-08-20T02:51:30ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-12-011210.3389/fbioe.2024.14953381495338Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trendsMarcos Agustina-Hernández0Emilio Francés-Herrero1María Gómez-Álvarez2Paula Alonso-Frías3Mónica Romeu4Ana Monzó5Hortensia Ferrero6Clara Bueno-Fernandez7Clara Bueno-Fernandez8Irene Cervelló9IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, SpainIVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, SpainIVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, SpainIVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, SpainAssisted Human Reproduction Unit, La Fe University and Polytechnic Hospital, Valencia, SpainAssisted Human Reproduction Unit, La Fe University and Polytechnic Hospital, Valencia, SpainIVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, SpainIVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, SpainDepartment of Pediatrics, Obstetrics and Gynecology, Faculty of Medicine, University of Valencia, Valencia, SpainIVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, SpainThe endometrium plays a fundamental role in the reproductive system yet many etiologies of infertility-related endometrial diseases such as endometriosis, adenomyosis, Asherman’s syndrome or endometrial cancer remain unknown. There are currently no treatments that minimize the effects of this devastating disorder. Appropriate model systems that closely mimic the architecture and function of the endometrium in healthy and pathological states are needed to understand the underlying molecular pathways and develop novel or more effective treatments. This review summarizes the key milestones of in vitro culture models of the human endometrium throughout history, as well as the applications of advanced bioengineering techniques in the modelling of both healthy and pathological endometrium. Opportunities for future approaches are also discussed.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1495338/fullfemale reproductionendometrial modellingin vitro techniquesendometrial diseasescell culturetissue engineering |
| spellingShingle | Marcos Agustina-Hernández Emilio Francés-Herrero María Gómez-Álvarez Paula Alonso-Frías Mónica Romeu Ana Monzó Hortensia Ferrero Clara Bueno-Fernandez Clara Bueno-Fernandez Irene Cervelló Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends Frontiers in Bioengineering and Biotechnology female reproduction endometrial modelling in vitro techniques endometrial diseases cell culture tissue engineering |
| title | Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends |
| title_full | Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends |
| title_fullStr | Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends |
| title_full_unstemmed | Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends |
| title_short | Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends |
| title_sort | biotechnological progresses in modelling the human endometrium the evolution of current in vitro techniques and emerging trends |
| topic | female reproduction endometrial modelling in vitro techniques endometrial diseases cell culture tissue engineering |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1495338/full |
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