Pre-Clinical Toxicity Study and Safety Assessment of Candidate Live Pertussis Vaccine for Intranasal Administration
Against the backdrop of mass parenteral immunization by present pertussis vaccines the incidence rate of pertussis is recorded in many countries, as well as among adolescents and adults, according to the World Health Organisation data. The number of cases of pertussis complicated to detect is increa...
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2019-01-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/625 |
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| author | L. N. Sinyashina E. G. Semin A. Yu. Medkova R. A. Siundiukova G. I. Karataev |
| author_facet | L. N. Sinyashina E. G. Semin A. Yu. Medkova R. A. Siundiukova G. I. Karataev |
| author_sort | L. N. Sinyashina |
| collection | DOAJ |
| description | Against the backdrop of mass parenteral immunization by present pertussis vaccines the incidence rate of pertussis is recorded in many countries, as well as among adolescents and adults, according to the World Health Organisation data. The number of cases of pertussis complicated to detect is increased, meaning atypical forms and inapparent bacteria carrying. In the presence of appearance of Bordetella pertussis strains of «new» genotype the efficacy of current pertussis vaccines is decreased. Existing epidemiologic situation cries out for development of new, more efficient pertussis vaccines and improvement of immunization methods and schedules. The most promising for this problem solution are live pertussis vaccines, constructed with genetic engineering methods.The goal of present research is studying of toxicity and safety of innovative recombinant live pertussis vaccine for intranasal administration in animals.Obtained results demonstrate the absence of specific toxicity of candidate vaccine and its use safety in intranasal applying. |
| format | Article |
| id | doaj-art-5b03d3641a6b4cb7bcfa0e18e05c10a1 |
| institution | Kabale University |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj-art-5b03d3641a6b4cb7bcfa0e18e05c10a12025-08-20T03:57:18ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942019-01-011769810810.31631/2073-3046-2018-17-98-108499Pre-Clinical Toxicity Study and Safety Assessment of Candidate Live Pertussis Vaccine for Intranasal AdministrationL. N. Sinyashina0E. G. Semin1A. Yu. Medkova2R. A. Siundiukova3G. I. Karataev4Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian FederationGamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian FederationGamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian FederationGamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian FederationGamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian FederationAgainst the backdrop of mass parenteral immunization by present pertussis vaccines the incidence rate of pertussis is recorded in many countries, as well as among adolescents and adults, according to the World Health Organisation data. The number of cases of pertussis complicated to detect is increased, meaning atypical forms and inapparent bacteria carrying. In the presence of appearance of Bordetella pertussis strains of «new» genotype the efficacy of current pertussis vaccines is decreased. Existing epidemiologic situation cries out for development of new, more efficient pertussis vaccines and improvement of immunization methods and schedules. The most promising for this problem solution are live pertussis vaccines, constructed with genetic engineering methods.The goal of present research is studying of toxicity and safety of innovative recombinant live pertussis vaccine for intranasal administration in animals.Obtained results demonstrate the absence of specific toxicity of candidate vaccine and its use safety in intranasal applying.https://www.epidemvac.ru/jour/article/view/625live pertussis vaccineintranasal administrationtoxicitysurvivalvirulence |
| spellingShingle | L. N. Sinyashina E. G. Semin A. Yu. Medkova R. A. Siundiukova G. I. Karataev Pre-Clinical Toxicity Study and Safety Assessment of Candidate Live Pertussis Vaccine for Intranasal Administration Эпидемиология и вакцинопрофилактика live pertussis vaccine intranasal administration toxicity survival virulence |
| title | Pre-Clinical Toxicity Study and Safety Assessment of Candidate Live Pertussis Vaccine for Intranasal Administration |
| title_full | Pre-Clinical Toxicity Study and Safety Assessment of Candidate Live Pertussis Vaccine for Intranasal Administration |
| title_fullStr | Pre-Clinical Toxicity Study and Safety Assessment of Candidate Live Pertussis Vaccine for Intranasal Administration |
| title_full_unstemmed | Pre-Clinical Toxicity Study and Safety Assessment of Candidate Live Pertussis Vaccine for Intranasal Administration |
| title_short | Pre-Clinical Toxicity Study and Safety Assessment of Candidate Live Pertussis Vaccine for Intranasal Administration |
| title_sort | pre clinical toxicity study and safety assessment of candidate live pertussis vaccine for intranasal administration |
| topic | live pertussis vaccine intranasal administration toxicity survival virulence |
| url | https://www.epidemvac.ru/jour/article/view/625 |
| work_keys_str_mv | AT lnsinyashina preclinicaltoxicitystudyandsafetyassessmentofcandidatelivepertussisvaccineforintranasaladministration AT egsemin preclinicaltoxicitystudyandsafetyassessmentofcandidatelivepertussisvaccineforintranasaladministration AT ayumedkova preclinicaltoxicitystudyandsafetyassessmentofcandidatelivepertussisvaccineforintranasaladministration AT rasiundiukova preclinicaltoxicitystudyandsafetyassessmentofcandidatelivepertussisvaccineforintranasaladministration AT gikarataev preclinicaltoxicitystudyandsafetyassessmentofcandidatelivepertussisvaccineforintranasaladministration |