Time trends in preeclampsia and gestational diabetes in Denmark and Alberta, Canada, 2005–2018—A population‐based cohort study
Abstract Introduction Preeclampsia and gestational diabetes mellitus share risk factors such as obesity and increased maternal age, which have become more prevalent in recent decades. We examined changes in the prevalence of preeclampsia and gestational diabetes between 2005 and 2018 in Denmark and...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-02-01
|
| Series: | Acta Obstetricia et Gynecologica Scandinavica |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/aogs.14703 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850212233212067840 |
|---|---|
| author | Frederikke Lihme Ana Savu Saima Basit Winnie Sia Rose Yeung Olesya Barrett Leiah Luoma Deliwe P. Ngwezi Sandra Davidge Colleen M. Norris Maria B. Ospina Christy‐Lynn Cooke Russ Greiner Jan Wohlfahrt Mads Melbye Jacob Lykke Padma Kaul Heather A. Boyd |
| author_facet | Frederikke Lihme Ana Savu Saima Basit Winnie Sia Rose Yeung Olesya Barrett Leiah Luoma Deliwe P. Ngwezi Sandra Davidge Colleen M. Norris Maria B. Ospina Christy‐Lynn Cooke Russ Greiner Jan Wohlfahrt Mads Melbye Jacob Lykke Padma Kaul Heather A. Boyd |
| author_sort | Frederikke Lihme |
| collection | DOAJ |
| description | Abstract Introduction Preeclampsia and gestational diabetes mellitus share risk factors such as obesity and increased maternal age, which have become more prevalent in recent decades. We examined changes in the prevalence of preeclampsia and gestational diabetes between 2005 and 2018 in Denmark and Alberta, Canada, and investigated whether the observed trends can be explained by changes in maternal age, parity, multiple pregnancy, comorbidity, and body mass index (BMI) over time. Material and methods This study was a register‐based cohort study conducted using data from the Danish National Health Registers and the provincial health registers of Alberta, Canada. We included in the study cohort all pregnancies in 2005–2018 resulting in live‐born infants and used binomial regression to estimate mean annual increases in the prevalence of preeclampsia and gestational diabetes in the two populations across the study period, adjusted for maternal characteristics. Results The study cohorts included 846 127 (Denmark) and 706 728 (Alberta) pregnancies. The prevalence of preeclampsia increased over the study period in Denmark (2.5% to 2.9%) and Alberta (1.7% to 2.5%), with mean annual increases of 0.03 (95% confidence interval [CI] 0.02–0.04) and 0.06 (95% CI 0.05–0.07) percentage points, respectively. The prevalence of gestational diabetes also increased in Denmark (1.9% to 4.6%) and Alberta (3.9% to 9.2%), with average annual increases of 0.20 (95% CI 0.19–0.21) and 0.44 (95% CI 0.42–0.45) percentage points. Changes in the distributions of maternal age and BMI contributed to increases in the prevalence of both conditions but could not explain them entirely. Conclusions The prevalence of both preeclampsia and gestational diabetes increased significantly from 2005 to 2018, which portends future increases in chronic disease rates among affected women. Increasing demand for long‐term follow up and care will amplify the existing pressure on healthcare systems. |
| format | Article |
| id | doaj-art-5affdf22a08a4f1c8d63ef85bd4a1878 |
| institution | OA Journals |
| issn | 0001-6349 1600-0412 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Acta Obstetricia et Gynecologica Scandinavica |
| spelling | doaj-art-5affdf22a08a4f1c8d63ef85bd4a18782025-08-20T02:09:24ZengWileyActa Obstetricia et Gynecologica Scandinavica0001-63491600-04122024-02-01103226627510.1111/aogs.14703Time trends in preeclampsia and gestational diabetes in Denmark and Alberta, Canada, 2005–2018—A population‐based cohort studyFrederikke Lihme0Ana Savu1Saima Basit2Winnie Sia3Rose Yeung4Olesya Barrett5Leiah Luoma6Deliwe P. Ngwezi7Sandra Davidge8Colleen M. Norris9Maria B. Ospina10Christy‐Lynn Cooke11Russ Greiner12Jan Wohlfahrt13Mads Melbye14Jacob Lykke15Padma Kaul16Heather A. Boyd17Department of Epidemiology Research Statens Serum Institut Copenhagen DenmarkCanadian VIGOUR Center University of Alberta Edmonton CanadaDepartment of Epidemiology Research Statens Serum Institut Copenhagen DenmarkDepartment of Medicine University of Alberta Edmonton CanadaDepartment of Medicine University of Alberta Edmonton CanadaAlberta Health Services Edmonton Alberta CanadaCanadian VIGOUR Center University of Alberta Edmonton CanadaCanadian VIGOUR Center University of Alberta Edmonton CanadaDepartments of Obstetrics/Gynecology and Physiology University of Alberta Edmonton CanadaDepartment of Medicine University of Alberta Edmonton CanadaDepartment of Public Health Sciences Queen's University Kingston Ontario CanadaDepartments of Obstetrics/Gynecology and Physiology University of Alberta Edmonton CanadaDepartment of Computer Science University of Alberta Edmonton CanadaDepartment of Epidemiology Research Statens Serum Institut Copenhagen DenmarkDanish Cancer Society Research Center Copenhagen DenmarkDepartment of Obstetrics and Gynecology Rigshospitalet Copenhagen DenmarkCanadian VIGOUR Center University of Alberta Edmonton CanadaDepartment of Epidemiology Research Statens Serum Institut Copenhagen DenmarkAbstract Introduction Preeclampsia and gestational diabetes mellitus share risk factors such as obesity and increased maternal age, which have become more prevalent in recent decades. We examined changes in the prevalence of preeclampsia and gestational diabetes between 2005 and 2018 in Denmark and Alberta, Canada, and investigated whether the observed trends can be explained by changes in maternal age, parity, multiple pregnancy, comorbidity, and body mass index (BMI) over time. Material and methods This study was a register‐based cohort study conducted using data from the Danish National Health Registers and the provincial health registers of Alberta, Canada. We included in the study cohort all pregnancies in 2005–2018 resulting in live‐born infants and used binomial regression to estimate mean annual increases in the prevalence of preeclampsia and gestational diabetes in the two populations across the study period, adjusted for maternal characteristics. Results The study cohorts included 846 127 (Denmark) and 706 728 (Alberta) pregnancies. The prevalence of preeclampsia increased over the study period in Denmark (2.5% to 2.9%) and Alberta (1.7% to 2.5%), with mean annual increases of 0.03 (95% confidence interval [CI] 0.02–0.04) and 0.06 (95% CI 0.05–0.07) percentage points, respectively. The prevalence of gestational diabetes also increased in Denmark (1.9% to 4.6%) and Alberta (3.9% to 9.2%), with average annual increases of 0.20 (95% CI 0.19–0.21) and 0.44 (95% CI 0.42–0.45) percentage points. Changes in the distributions of maternal age and BMI contributed to increases in the prevalence of both conditions but could not explain them entirely. Conclusions The prevalence of both preeclampsia and gestational diabetes increased significantly from 2005 to 2018, which portends future increases in chronic disease rates among affected women. Increasing demand for long‐term follow up and care will amplify the existing pressure on healthcare systems.https://doi.org/10.1111/aogs.14703gestational diabetesmaternal characteristicspreeclampsiapregnancytime trends |
| spellingShingle | Frederikke Lihme Ana Savu Saima Basit Winnie Sia Rose Yeung Olesya Barrett Leiah Luoma Deliwe P. Ngwezi Sandra Davidge Colleen M. Norris Maria B. Ospina Christy‐Lynn Cooke Russ Greiner Jan Wohlfahrt Mads Melbye Jacob Lykke Padma Kaul Heather A. Boyd Time trends in preeclampsia and gestational diabetes in Denmark and Alberta, Canada, 2005–2018—A population‐based cohort study Acta Obstetricia et Gynecologica Scandinavica gestational diabetes maternal characteristics preeclampsia pregnancy time trends |
| title | Time trends in preeclampsia and gestational diabetes in Denmark and Alberta, Canada, 2005–2018—A population‐based cohort study |
| title_full | Time trends in preeclampsia and gestational diabetes in Denmark and Alberta, Canada, 2005–2018—A population‐based cohort study |
| title_fullStr | Time trends in preeclampsia and gestational diabetes in Denmark and Alberta, Canada, 2005–2018—A population‐based cohort study |
| title_full_unstemmed | Time trends in preeclampsia and gestational diabetes in Denmark and Alberta, Canada, 2005–2018—A population‐based cohort study |
| title_short | Time trends in preeclampsia and gestational diabetes in Denmark and Alberta, Canada, 2005–2018—A population‐based cohort study |
| title_sort | time trends in preeclampsia and gestational diabetes in denmark and alberta canada 2005 2018 a population based cohort study |
| topic | gestational diabetes maternal characteristics preeclampsia pregnancy time trends |
| url | https://doi.org/10.1111/aogs.14703 |
| work_keys_str_mv | AT frederikkelihme timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT anasavu timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT saimabasit timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT winniesia timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT roseyeung timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT olesyabarrett timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT leiahluoma timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT deliwepngwezi timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT sandradavidge timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT colleenmnorris timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT mariabospina timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT christylynncooke timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT russgreiner timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT janwohlfahrt timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT madsmelbye timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT jacoblykke timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT padmakaul timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy AT heatheraboyd timetrendsinpreeclampsiaandgestationaldiabetesindenmarkandalbertacanada20052018apopulationbasedcohortstudy |